Method for the detection of gene transcripts in blood and uses thereof

ABSTRACT

The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of application Ser. No. 10/268,730 filed on Oct. 9, 2002, which is a continuation of U.S. application Ser. No. 09/477,148 filed Jan. 4, 2000, now abandoned, which claims the benefit of U.S. Provisional Application No. 60/115,125 filed on Jan. 6, 1999, now abandoned. Each of these applications is incorporated herein by reference in their entirety, including the figures and drawings.

FIELD OF THE INVENTION

The present invention relates generally to the molecular biology of human diseases. More specifically, the present invention relates to a process using the genetic information contained in human peripheral whole blood for the diagnosis, prognosis and monitoring of genetic and infectious disease in the human body.

DESCRIPTION OF THE RELATED ART

The blood is a vital part of the human circulatory system for the human body. Numerous cell types make up the blood tissue including monocytes, leukocytes, lymphocytes and erythrocytes. Although many blood cell types have been described, there are likely many as yet undiscovered cell types in the human blood. Some of these undiscovered cells may exist transiently, such as those derived from tissues and organs that are constantly interacting with the circulating blood in health and disease. Thus, the blood can provide an immediate picture of what is happening in the human body at any given time.

The turnover of cells in the hematopoietic system is enormous. It was reported that over one trillion cells, including 200 billion erythrocytes and 70 billion neutrophilic leukocytes, turn over each day in the human body (Ogawa 1993). As a consequence of continuous interactions between the blood and the body, genetic changes that occur within the cells or tissues of the body will trigger specific changes in gene expression within blood. It is the goal of the present invention that these genetic alterations be harnessed for diagnostic and prognostic purposes, which may lead to the development of therapeutics for ameliorating disease.

The complete profile of gene expression in the circulating blood remains totally unexplored. It is hypothesized that gene expression in the blood is reflective of body state and, as such, the resultant disruption of homeostasis under conditions of disease can be detected through analysis of transcripts differentially expressed in the blood alone. Thus, the identification of several key transcripts or genetic markers in blood will provide information about the genetic state of the cells, tissues, organ systems of the human body in health and disease.

The prior art is deficient in non-invasive methods of screening for tissue-specific diseases. The present invention fulfills this long-standing need and desire in the art.

SUMMARY OF THE INVENTION

This present invention discloses a process of using the genetic information contained in human peripheral whole blood in the diagnosis, prognosis and monitoring of genetic and infectious disease in the human body. The process described herein requires a simple blood sample and is, therefore, non-invasive compared to conventional practices used to detect tissue specific disease, such as biopsies.

One object of the present invention is to provide a non-invasive method for the diagnosis, prognosis and monitoring of genetic and infectious disease in humans and animals.

In one embodiment of the present invention, there is provided a method for detecting expression of a gene in blood from a subject, comprising the steps of: a) quantifying RNA from a subject blood sample; and b) detecting expression of the gene in the quantified RNA, wherein the expression of the gene in quantified RNA indicates the expression of the gene in the subject blood.

In another embodiment of the present invention, there is provided a method for detecting expression of one or more genes in blood from a subject, comprising the steps of: a) obtaining a subject blood sample; b) extracting RNA from the blood sample; c) amplifying the RNA; d) generating expressed sequence tags (ESTs) from the amplified RNA product; and e) detecting expression of the genes in the ESTs, wherein the expression of the genes in the ESTs indicates the expression of the genes in the subject blood. Preferably, the genes are tissue-specific genes.

In still another embodiment of the present invention, there is provided a method for detecting expression of one or more genes in blood from a subject, comprising the steps of: a) obtaining a subject blood sample; b) extracting DNA fragments from the blood sample; c) amplifying the DNA fragments; and d) detecting expression of the genes in the amplified DNA product, wherein the expression of the genes in the amplified DNA product indicates the expression of the genes in the subject blood.

In yet another embodiment of the present invention, there is provided a method for monitoring a course of a therapeutic treatment in an individual, comprising the steps of: a) obtaining a blood sample from the individual; b) extracting RNA from the blood sample; c) amplifying the RNA; d) generating expressed sequence tags (ESTs) from the amplified RNA product; e) detecting expression of genes in the ESTs, wherein the expression of the genes is associated with the effect of the therapeutic treatment; and f) repeating steps a)-e), wherein the course of the therapeutic treatment is monitored by detecting the change of expression of the genes in the ESTs. Such a method may also be used for monitoring the onset of overt symptoms of a disease, wherein the expression of the genes is associated with the onset of the symptoms.

In still yet another embodiment of the present invention, there is provided a method for diagnosing a disease in a test subject, comprising the steps of: a) generating a cDNA library for the disease from a whole blood sample from a normal subject; b) generating expressed sequence tag (EST) profile from the normal subject cDNA library; c) generating a cDNA library for the disease from a whole blood sample from a test subject; d) generating EST profile from the test subject cDNA library; and e) comparing the test subject EST profile to the normal subject EST profile, wherein if the test subject EST profile differs from the normal subject EST profile, the test subject might be diagnosed with the disease.

In still yet another embodiment of the present invention, there is provided a kit for diagnosing, prognosing or predicting a disease, comprising: a) gene-specific primers; wherein the primers are designed in such a way that their sequences contain the opposing ends of two adjacent exons for the specific gene with the intron sequence excluded; and b) a carrier, wherein the carrier immobilizes the primer(s). Such a kit may be applied to a test subject whole blood sample to diagnose, prognose or predict a disease.

In yet another embodiment of the present invention, there is provided a kit for diagnosing, prognosing or predicting a disease, comprising: a) probes derived from a whole blood sample for a specific disease; and b) a carrier, wherein the carrier immobilizes the probes. Such a kit may be applied to a test subject whole blood sample to diagnose, prognose or predict a disease.

Furthermore, the present invention provides a cDNA library specific for a disease, wherein the cDNA library is generated from whole blood samples.

Other and further aspects, features, and advantages of the present invention will be apparent from the following description of the presently preferred embodiments of the invention. These embodiments are given for the purpose of disclosure.

BRIEF DESCRIPTION OF THE DRAWINGS

So that the matter in which the above-recited features, advantages and objects of the invention, as well as others which will become clear, are attained and can be understood in detail, more particular descriptions of the invention briefly summarized above may be had by reference to certain embodiments thereof which are illustrated in the appended drawings. These drawings form a part of the specification. It is to be noted, however, that the appended drawings illustrate preferred embodiments of the invention and therefore are not to be considered limiting in their scope.

FIG. 1 shows the following RNA samples prepared from human blood; FIG. 1A: Lane 1, Molecular weight marker; Lane 2, RT-PCR on APP gene; Lane 3, PCR on APP gene; Lane 4, RT-PCR on APC gene; Lane 5, PCR on APC gene; FIG. 1B: Lanes 1 and 2, RT-PCR and PCR of βMyHC, respectively; Lanes 3 and 4, RT-PCR of βMyHC from RNA prepared from human fetal and human adult heart, respectively; Lane 5, Molecular weight marker.

FIG. 2 shows quantitative RT-PCR analysis performed on RNA samples extracted from a drop of blood. Forward primer (5′-GCCCTCTGGGGACCTGAC-3′, SEQ ID No. 1) of exon 1 and reverse primer (5′-CCCACCTGCAGGTCCTCT-3″, SEQ ID No. 2) of exons 1 and 2 of insulin gene. Blood samples of 4 normal subjects were assayed. Lanes 1, 3, 5 and 7 represent overnight “fasting” blood sample and lanes 2, 4, 6 and 8 represent “non-fasting” samples.

FIG. 3 shows quantitative RT-PCR analysis performed on RNA samples extracted from a drop of blood. Lanes 1 and 2 represent normal healthy person and lane 3 represents late-onset diabetes (Type II) and lane 4 represents asymptomatic diabetes.

FIG. 4 shows multiple RT-PCR assay in a drop of blood. Primers were derived from insulin gene (INS), zinc-finger protein gene (ZFP) and house-keeping gene (GADH). Lane 1 represents normal person. Lane 2 represents late-onset diabetes and lane 3 represents asymptomatic diabetes.

FIG. 5 shows standardized levels of insulin gene (FIG. 5A) and ZFP gene (FIG. 5B) expressed in a drop of blood. The first three subjects were normal, second two subjects showed normal glucose tolerance, and the last subject had late onset diabetes type II. FIG. 5C shows standardized levels of insulin gene expressed in each fractionated cell from whole blood.

FIG. 6 shows the differential screening of human blood cell cDNA library with different cDNA probes of heart and brain tissue. FIG. 6A shows blood cell cDNA probes vs. adult heart cDNA probes. FIG. 6B shows blood cell cDNA probes vs. human brain cDNA probes.

FIG. 7 graphically shows the 1,800 unique genes in human blood and in the human fetal heart grouped into seven cellular functions.

DETAILED DESCRIPTION OF THE INVENTION

In accordance with the present invention, there may be employed conventional molecular biology, microbiology, and recombinant DNA techniques within the skill of the art. Such techniques are explained fully in the literature. See, e.g., Sambrook, Fritsch & Maniatis, “Molecular Cloning: A Laboratory Manual (1982); “DNA Cloning: A Practical Approach,” Volumes I and II (D. N. Glover ed. 1985); “Oligonucleotide Synthesis” (M. J. Gait ed. 1984); “Nucleic Acid Hybridization” [B. D. Hames & S. J. Higgins eds. (1985)]; “Transcription and Translation” [B. D. Hames & S. J. Higgins eds. (1984)]; “Animal Cell Culture” [R. I. Freshney, ed. (1986)]; “Immobilized Cells And Enzymes” [IRL Press, (1986)]; B. Perbal, “A Practical Guide To Molecular Cloning” (1984). Therefore, if appearing herein, the following terms shall have the definitions set out below.

A “cDNA” is defined as copy-DNA or complementary-DNA, and is a product of a reverse transcription reaction from an mRNA transcript. “RT-PCR” refers to reverse transcription polymerase chain reaction and results in production of cDNAs that are complementary to the mRNA template(s).

The term “oligonucleotide” is defined as a molecule comprised of two or more deoxyribonucleotides, preferably more than three. Its exact size will depend upon many factors which, in turn, depend upon the ultimate function and use of the oligonucleotide. The term “primer” as used herein refers to an oligonucleotide, whether occurring naturally as in a purified restriction digest or produced synthetically, which is capable of acting as a point of initiation of synthesis when placed under conditions in which synthesis of a primer extension product, which is complementary to a nucleic acid strand, is induced, i.e., in the presence of nucleotides and an inducing agent such as a DNA polymerase and at a suitable temperature and pH. The primer may be either single-stranded or double-stranded and must be sufficiently long to prime the synthesis of the desired extension product in the presence of the inducing agent. The exact length of the primer will depend upon many factors, including temperature, source of primer and the method used. For example, for diagnostic applications, depending on the complexity of the target sequence, the oligonucleotide primer typically contains 15-25 or more nucleotides, although it may contain fewer nucleotides. The factors involved in determining the appropriate length of primer are readily known to one of ordinary skill in the art.

As used herein, random sequence primers refer to a composition of primers of random sequence, i.e. not directed towards a specific sequence. These sequences possess sufficient complementary to hybridize with a polynucleotide and the primer sequence need not reflect the exact sequence of the template.

“Restriction fragment length polymorphism” refers to variations in DNA sequence detected by variations in the length of DNA fragments generated by restriction endonuclease digestion.

A standard Northern blot assay can be used to ascertain the relative amounts of mRNA in a cell or tissue obtained from plant or other tissue, in accordance with conventional Northern hybridization techniques known to those persons of ordinary skill in the art. The Northern blot uses a hybridization probe, e.g. radiolabelled cDNA, either containing the full-length, single stranded DNA or a fragment of that DNA sequence at least 20 (preferably at least 30, more preferably at least 50, and most preferably at least 100 consecutive nucleotides in length). The DNA hybridization probe can be labelled by any of the many different methods known to those skilled in this art. The labels most commonly employed for these studies are radioactive elements, enzymes, chemicals which fluoresce when exposed to untraviolet light, and others. A number of fluorescent materials are known and can be utilized as labels. These include, for example, fluorescein, rhodamine, auramine, Texas Red, AMCA blue and Lucifer Yellow. A particular detecting material is anti-rabbit antibody prepared in goats and conjugated with fluorescein through an isothiocyanate. Proteins can also be labeled with a radioactive element or with an enzyme. The radioactive label can be detected by any of the currently available counting procedures. The preferred isotope may be selected from ³H, ¹⁴C, ³²P, ³⁵S, ³⁶Cl, ⁵¹Cr, ⁵⁷Co, ⁵⁸Co, ⁵⁹Fe, ⁹⁰Y, ¹²⁵I, ¹³¹I, and ¹⁸⁶Re. Enzyme labels are likewise useful, and can be detected by any of the presently utilized colorimetric, spectrophotometric, fluorospectrophotometric, amperometric or gasometric techniques. The enzyme is conjugated to the selected particle by reaction with bridging molecules such as carbodiimides, diisocyanates, glutaraldehyde and the like. Many enzymes which can be used in these procedures are known and can be utilized. The preferred are peroxidase, β-glucuronidase, β-D-glucosidase, β-D-galactosidase, urease, glucose oxidase plus peroxidase and alkaline phosphatase. U.S. Pat. Nos. 3,654,090, 3,850,752, and 4,016,043 are referred to by way of example for their disclosure of alternate labeling material and methods.

As used herein, “individual” refers to human subjects as well as non-human subjects. The examples herein are not meant to limit the methodology of the present invention to human subjects only, as the instant methodology is useful in the fields of veterinary medicine, animal sciences and such.

In one embodiment of the present invention, there is provided a method for detecting expression of a gene in blood from a subject, comprising the steps of: a) quantifying RNA from a subject blood sample; and b) detecting expression of the gene in the quantified RNA, wherein the expression of the gene in quantified RNA indicates the expression of the gene in the subject blood. An example of the quantifying method is by mass spectrometry.

In another embodiment of the present invention, there is provided a method for detecting expression of one or more genes in blood from a subject, comprising the steps of: a) obtaining a subject blood sample; b) extracting RNA from the blood sample; c) amplifying the RNA; d) generating expressed sequence tags (ESTs) from the amplified RNA product; and e) detecting expression of the genes in the ESTs, wherein the expression of the genes in the ESTs indicates the expression of the genes in the subject blood. Preferably, the subject is a fetus, an embryo, a child, an adult or a non-human animal. The genes are non-cancer-associated and tissue-specific genes. Still preferably, the amplification is performed by RT-PCR using random sequence primers or gene-specific primers.

In still another embodiment of the present invention, there is provided a method for detecting expression of one or more genes in blood from a subject, comprising the steps of: a) obtaining a subject blood sample; b) extracting DNA fragments from the blood sample; c) amplifying the DNA fragments; and d) detecting expression of the genes in the amplified DNA product, wherein the expression of the genes in the amplified DNA product indicates the expression of the genes in the subject blood.

In yet another embodiment of the present invention, there is provided a method for monitoring a course of a therapeutic treatment in an individual, comprising the steps of: a) obtaining a blood sample from the individual; b) extracting RNA from the blood sample; c) amplifying the RNA; d) generating expressed sequence tags (ESTs) from the amplified RNA product; e) detecting expression of genes in the ESTs, wherein the expression of the genes is associated with the effect of the therapeutic treatment; and f) repeating steps a)-e), wherein the course of the therapeutic treatment is monitored by detecting the change of expression of the genes in the ESTs. Such a method may also be used for monitoring the onset of overt symptoms of a disease, wherein the expression of the genes is associated with the onset of the symptoms. Preferably, the amplification is performed by RT-PCR, and the change of the expression of the genes in the ESTs is monitored by sequencing the ESTs and comparing the resulting sequences at various time points; or by performing single nucleotide polymorphism analysis and detecting the variation of a single nucleotide in the ESTs at various time points.

In still yet another embodiment of the present invention, there is provided a method for diagnosing a disease in a test subject, comprising the steps of: a) generating a cDNA library for the disease from a whole blood sample from a normal subject; b) generating expressed sequence tag (EST) profile from the normal subject cDNA library; c) generating a cDNA library for the disease from a whole blood sample from a test subject; d) generating EST profile from the test subject cDNA library; and e) comparing the test subject EST profile to the normal subject EST profile, wherein if the test subject EST profile differs from the normal subject EST profile, the test subject might be diagnosed with the disease.

In still yet another embodiment of the present invention, there is provided a kit for diagnosing, prognosing or predicting a disease, comprising: a) gene-specific primers; wherein the primers are designed in such a way that their sequences contain the opposing ends of two adjacent exons for the specific gene with the intron sequence excluded; and b) a carrier, wherein the carrier immobilizes the primer(s). Preferably, the gene-specific primers are selected from the group consisting of insulin-specific primers, atrial natriuretic factor-specific primers, zinc finger protein gene-specific primers, beta-myosin heavy chain gene-specific primers, amyloid precursor protein gene-specific primers, and adenomatous polyposis-coli protein gene-specific primers. Further preferably, the gene-specific primers are selected from the group consisting of SEQ ID Nos. 1 and 2; and SEQ ID Nos. 5 and 6. Such a kit may be applied to a test subject whole blood sample to diagnose, prognose or predict a disease by detecting the quantitative expression levels of specific genes associated with the disease in the test subject and then comparing to the levels of same genes expressed in a normal subject. Such a kit may also be used for monitoring a course of therapeutic treatment or monitoring the onset of overt symptoms of a disease.

In yet another embodiment of the present invention, there is provided a kit for diagnosing, prognosing or predicting a disease, comprising: a) probes derived from a whole blood sample for a specific disease; and b) a carrier, wherein the carrier immobilizes the probes. Such a kit may be applied to a test subject whole blood sample to diagnose, prognose or predict a disease by detecting the quantitative expression levels of specific genes associated with the disease in the test subject and then comparing to the levels of same genes expressed in a normal subject. Such a kit may also be used for monitoring a course of therapeutic treatment or monitoring the onset of overt symptoms of a disease.

Furthermore, the present invention provides a cDNA library specific for a disease, wherein the cDNA library is generated from whole blood samples.

The following examples are given for the purpose of illustrating various embodiments of the invention and are not meant to limit the present invention in any fashion.

Example 1 Construction of a cDNA Library

RNA extracted from human tissues (including fetal heart, adult heart, liver, brain, prostate gland and whole blood) were used to construct unidirectional cDNA libraries. The first mammalian heart cDNA library was constructed as early as 1982. Since then, the methodology has been revised and optimal conditions have been developed for construction of human heart and hematopoietic progenitor cDNA libraries (Liew et al., 1984; Liew 1993, Claudio et al., 1998). Most of the novel genes which were identified by sequence annotation can now be obtained as full length transcripts.

Example 2 Catalogue of Blood Cell ESTs

Random partial sequencing of expressed sequence tags (ESTs) of cDNA clones from the blood cell library was carried out to establish an EST database of blood. The known genes as derived from the ESTs were categorized into seven major cellular functions (Hwang, Dempsey et al., 1997).

Example 3 Differential Screening of cDNA Library

cDNA probes generated from transcripts of each tissue were used to hybridize the blood cell cDNA clones (Liew et al., 1997). The “positive” signals which were hybridized with P-labelled cDNA probes were defined as genes which shared identity with blood and respective tissues. The “negative” spots which were not exposed to P-labelled cDNA probes were considered to be blood-cell-enriched or low frequency transcripts.

Example 4 Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) Assay

RNA extracted from samples of human tissue was used for RT-PCR analysis (Jin et al. 1990). Three pairs of forward and reverse primers were designed for human cardiac beta-myosin heavy chain gene (βMyHC), amyloid precursor protein (APP) gene and adenomatous polyposis-coli protein (APC) gene. The PCR products were also subjected to automated DNA sequencing to verify the sequences as derived from the specific transcripts of blood.

Example 5 Detection of Tissue Specific Gene Expression in Human Blood Using RT-PCR

The beta-myosin heavy chain gene (βMyHC) transcript (mRNA) is known to be highly expressed in ventricles of the human heart. This sarcomeric protein is important for heart muscle contraction and its presence would not be expected in other non-muscle tissues and blood. In 1990, the gene for human cardiac βMyHC was completely sequenced (Liew et al. 1990) and was comprised of 41 exons and 42 introns.

The method of reverse transcription polymerase chain reaction (RT-PCR) was used to determine whether this cardiac specific mRNA is also present in human blood. A pair of primers was designed; the forward primer (SEQ ID No. 3) was on the boundary of exons 21 and 22, and the reverse primer (SEQ ID No. 4) was on the boundary of exons 24 and 25. This region of mRNA is only present in βMyHC and is not found in the alpha-myosin heavy chain gene (αMyHC).

A blood sample was first treated with lysing buffer and then undergone centrifuge. The resulting pellets were further processed with RT-PCR. RT-PCR was performed using the total blood cell RNA as a template. A nested PCR product was generated and used for sequencing. The sequencing results were subjected to BLAST and the identity of exons 21 to 25 was confirmed to be from βMyHC (FIG. 1A).

Using the same method just described, two other tissue specific genes—amyloid precursor protein (APP, forward primer, SEQ ID No. 7; reverse primer, SEQ ID No. 8) found in the brain and associated with Alzheimer's disease, and adenomatous polyposis coli protein (APC) found in the colon and rectum and associated with colorectal cancer (Groden et al. 1991; Santoro and Groden 1997) —were also detected in the RNA extracted from human blood (FIG. 1B).

Example 6 Multiple RT-PCR Analysis on a Drop of Blood from a Normal/Diseased Individual

A drop of blood was extracted to obtain RNA to carry out quantitative RT-PCR analysis. Specific primers for the insulin gene were designed: forward primer (5′-GCCCTCTGGGGACCTGAC-3′, SEQ ID No. 1) of exon 1 and reverse primer (5′-CCCACCTGCAGGTCCTCT-3″, SEQ ID No. 2) of exons 1 and 2 of insulin gene. Such reverse primer was obtained by deleting the intron between the exons 1 and 2. Blood samples of 4 normal subjects were assayed. It was found that the insulin gene is expressed in the blood and the quantitative expression of the insulin gene in a drop of blood is influenced by fasting and non-fasting states of normal healthy subjects (FIG. 2). This very low level of expression of the insulin gene reflects the phenotypic status of a person and strongly suggests that there is a physiological and pathological role for its expression, contrary to the basal or illegitimate theory of transcription suggested by Chelly et al. (1989) and Kimoto (1998).

Same quantitative RT-PCR analysis was performed using insulin specific primers on RNA samples extracted from a drop of blood from a normal healthy person, a person having late-onset diabetes (Type II) and a person having asymptomatic diabetes. It was found that the insulin gene is expressed differentially amongst subjects that are healthy, diagnosed as type II diabetic, and also in an asymptomatic preclinical patient (FIG. 3).

Similarly, specific primers for the atrial natriuretic factor (ANF) gene were designed (forward primer, SEQ ID No. 5; reverse primer, SEQ ID No. 6) and RT-PCR analysis was performed on a drop of blood. ANF is known to be highly expressed in heart tissue biopsies and in the plasma of heart failure patients. However, atrial natriuretic factor was observed to be expressed in the blood and the expression of the atrial natriuretic factor gene is significantly higher in the blood of patients with heart failure as compared to the blood of a normal control patient.

Specific primers for the zinc finger protein gene (ZFP, forward primer, SEQ ID No. 9; reverse primer, SEQ ID No. 10) were also designed and RT-PCR analysis was performed on a drop of blood. ZFP is known to be high in heart tissue biopsies of cardiac hypertrophy and heart failure patients. In the present study, the expression of ZFP was observed in the blood as well as differential expression levels of ZFP amongst the normal, diabetic and asymptomatic preclinical subjects (FIG. 4); although neither of the non-normal subjects has been specifically diagnosed as suffering from cardiac hypertrophy and/or heart failure, the higher expression levels of the ZFP gene in their blood may indicate that these subjects are headed in that general direction.

It was hypothesized that a housekeeping gene such as glyceraldehyde dehydrogenase (GADH) which is required and highly expressed in all cells would not be differentially expressed in the blood of normal vs. disease subjects. This hypothesis was confirmed by RT-PCR using GADH specific primers (FIG. 4). Thus, GADH is useful as an internal control.

Standardized levels of insulin gene or ZFP gene expressed in a drop of blood were estimated using a housekeeping gene as an internal control relative to insulin or ZFP expressed (FIGS. 5A & 5B). The levels of insulin gene expressed in each fractionated cell from whole blood were also standardized and shown in FIG. 5C.

Example 7 Human Blood Cell cDNA Library

In order to further substantiate the present invention, differential screening of the human blood cell cDNA library was conducted. cDNA probes derived from human blood, adult heart or brain were respectively hybridized to the human blood cDNA library clones. As shown in FIG. 7, more than 95% of the “positively” identified clones are identical between the blood and other tissue samples.

DNA sequencing of randomly selected clones from the human whole blood cell cDNA library was also performed. This allowed information regarding the cellular function of blood to be obtained concurrently with gene identification. More than 20,000 expressed sequence tags (ESTs) have been generated and characterized to date, 17.6% of which did not result in a statistically significant match to entries in the GenBank databases and thus were designated as “Novel” ESTs. These results are summarized in FIG. 7 together with the seven cellular functions related to percent distribution of known genes in blood and in the fetal heart.

From 20,000 ESTs, 1,800 have been identified as known genes which may not all appear in the hemapoietic system. For example, the insulin gene and the atrial natriuretic factor gene have not been detected in these 20,000 ESTs but their transcripts were detected in a drop of blood, strongly suggesting that all transcripts of the human genome can be detected by performing RT-PCR analysis on a drop of blood.

In addition, approximately 400 novel genes have been identified from the 20,000 ESTs characterized to date, and these will be subjected to full length sequencing and open reading frame alignment to reduce the actual number of novel ESTs prior to screening for disease markers.

Analysis of the approximately 6,283 ESTs which have known matches in the GenBank databases revealed that this dataset represents over 1,800 unique genes. These genes have been catalogued into seven cellular functions. Comparisons of this set of unique genes with ESTs derived from human brain, heart, lung and kidney demonstrated a greater than 50% overlap in expression (Table 1).

TABLE 1 Overlap of Genes Expressed in Blood * Tissues ESTs ** Overlap in Blood brain 134,000 60% heart 65,000 59% lung 60,200 58% kidney 32,300 54% * Estimated from limited known genes of about 1,800 as derived from the database of 6,297 ESTs from human blood cell library. ** Obtained from the National Centre of Biotechnology Information (NCBI), U.S.A.

Example 8 Blood Cell ESTs

The results from the differential screening clearly indicate that the transcripts expressed in the whole blood are reflective of genes expressed in all cells and tissues of the body. More than 95% of detectable spots were identical from two different tissues. The remaining 5% of spots may represent cell- or tissue-specific transcripts; however, results obtained from partial sequencing to generate ESTs of these clones revealed most of them not to be cell- or tissue-specific transcripts. Therefore, the negative spots are postulated to be reflective of low abundance transcripts in the tissue from which the cDNA probes were derived.

An alternative approach that was employed to identify transcripts expressed at low levels is the large-scale generation of expressed sequence tags (ESTs). There is substantial evidence regarding the efficiency of this technology to detect previously characterized (known) and uncharacterized (unknown or novel) genes expressed in the cardiovascular system (Hwang & Dempsey et al. 1997). In the present invention, 20,000 ESTs have been produced from a human blood cell cDNA library and resulted in the identification of approximately 1,800 unique known genes (Table 2)

In the most recent GenBank release, analysis of more than 300,000 ESTs in the database (dbESTs) generated more than 48,000 gene clusters which are thought to represent approximately 50% of the genes in the human genome. Only 4,800 of the dbESTs are blood-derived. In the present invention, 20,000 ESTs have been obtained to date from a human blood cDNA library, which provides the world's most informative database with respect to blood cell transcripts. From the limited amount of information generated so far (i.e. 1,800 unique genes), it has already been determined that more than 50% of the transcripts are found in other cells or tissues of the human body (Table 2). Thus, it is expected that by increasing the number of ESTs generated, more genes will be identified that have an overlap in expression between the blood and other tissues. Furthermore, the transcripts for several genes which are known to have tissue-restricted patterns of expression (i.e. βMyHC, APP, APC, ANF, ZFP) have also been demonstrated to be present in blood.

Most recently, a cDNA library of human hematopoietic progenitor stem cells has also been constructed. From the limited set of 1,000 ESTs, there are at least 200 known genes that are shared with other tissue related genes (Claudio et al. 1998).

Table 2 demonstrates the expression of known genes of specific tissues in blood cells. Previously, only the presence of “housekeeping” genes would have been expected. Additionally, the presence of at least 25 of the currently known 500 genes corresponding to molecular drug targets was detected. These molecular drug targets are used in the treatment of a variety of diseases which involve inflammation, renal and cardiovascular function, neoplastic disease, immunomodulation and viral infection (Drews & Ryser, 1997). It is expected that additional novel ESTs will represent future molecular drug targets.

TABLE 2 Comparison of 1,800 Unique Genes Identified in the Blood Cell cDNA Library to Genes Previously Identified in Specific Tissues No. of Accession Tissue Distribution Gene Identification ESTs No. Bl Br H K Li Lu 100 kDa coactivator 2 U22055 + + 10 kD protein (BC10) 2 AF053470 + + + + 14-3-3 epsilon 2 U54778 + + + 14-3-3 protein 11 U28964 + + + 15 kDa selenoprotein 1 AF051894 + + + (SEP15) 1-phosphatidylinositol-4- 1 S78798 phosphate 5-kinase isoform C 23 kD highly basic protein 21 X56932 + + + + + + 2-5A-dependent RNase 1 L10381 2′-5′oligoadenylate 4 M87284 B synthetase 2 (OAS2) 26S proteasome subunit 11 1 AF086708 36 kDa phosphothyrosine 2 AJ223280 T + protein 3-7 gene product (non- 1 D64159 exact 86% aa) 3-phosphoglycerate 1 AF006043 T + + + dehydrogenase (PGAD) 3-prime-phosphoadenosine 2 U53447 + + + + + 5-prime-phosphosulfate synthase 1 (PAPSS1) 46 kd mannose 6- 1 X56257 phosphate receptor (MPR46) (low match) 5-aminoimidazole-4- 1 D89976 carboxamide ribonucleotide transformylase 5′-nucleotidase 3 D38524 T + + 6-phosphofructo-2- 1 D49818 + kinase/fructose-2,6- biphosphatase 4 (PFKFB4) 6-phosphofructo-2- 1 AF041829 kinase/fructose-2,6- bisphosphatase (PF2K) 71 kd heat shock cognate 23 Y00371 protein hsc70 76 kDa membrane protein 2 U81006 + + + + + (P76) 8-oxoguanine DNA 1 U96710 B + + glycosylase (OGG1) a disintegrin and 1 AF009615 T + metalloprotease domain 10 (ADAM10) a disintegrin and 1 D26579 B + metalloprotease domain 8 (ADAM8) A kinase anchor protein 95 2 Y11997 B, T + + (AKAP95) activated A kinase anchor protein, 2 X97335 + + + + 149 kD (AKAP149) A4 differentiation- 1 U93305 dependent protein (A4), triple LIM domain protein (LMO6), and synaptophysin (SYP); calcium channel alpha-1 subunit (CACNA1F) ABL and putative M8604 1 U07561 Met protein Absent in melanoma 1 1 U83115 + + + (AIM1) accessory proteins 2 Z31696 + + BAP31/BAP29 (DXS1357E) acetyl-Coenzyme A 2 X12966 + + + + + + acyltransferase (peroxisomal 3-oxoacyl- Coenzyme A thiolase) (ACAA) acetyl-Coenzyme A 1 D88152 T lymphoma + + transporter (ACATN) acidic 82 kDa protein 4 U15552 acidic protein rich in 1 Y07969 B + + + + leucines (SSP29) Aconitase 2, mitochondrial 1 U80040 + + + + + (ACO2) actin binding protein 1 AF059569 MAYVEN actin, beta (ACTB) 158 X04098 T, B + + + actin, beta (ACTB) (non- 1 M10277 exact, low match 73%) actin, gamma (low score) 1 K00791 actin, gamma 1 (ACTG1) 4 X04098 + + + + + + high in many libraries actin-binding LIM protein 4 D31883 + + + + (ABLIM) Actinin, alpha 1 (ACTN1) 8 M95178 + + + + actinin, alpha 4 (ACTN4) 1 D89980 + + + activated p21cdc42Hs 1 L13738 B + + kinase (ACK) activated RNA polymerase 1 X79805 + + + + + II transcription cofactor 4 (PC4) activating transcription 1 X55544 + factor 1 (ATF1) activating transcription 1 X15875 + + + factor 2 (ATF2) activating transcription 2 M86842 + + factor 4 (tax-responsive enhancer element B67) (ATF4) active BCR-related gene 1 U01147 + + + + + (ABR) acyl-CoA oxidase (AOX) 1 U03254 acyl-Coenzyme A 2 M16827 dehydrogenase, C-4 to C- 12 straight chain (ACADM) acyl-Coenzyme A 3 D43682 + + + + + + dehydrogenase, very long chain (ACADVL) acyloxyacyl hydrolase 3 M62840 T + + + (neutrophil) (AOAH) adaptin, delta (ADTD) 2 U91930 + + + adaptin, delta (ADTD) (non- 1 AC005328 exact 59%) adaptin, gamma (ADTG) 1 Y12226 + + + + adaptor complex sigma3B 2 X99459 + + + (AP3S3) adaptor protein p150 1 Y08991 adducin 1 (alpha) (ADD1) 2 L07261 + + + adducin 1 (alpha) (add1) 3 L29296 + + + + + adducin 3 (gamma) (ADD3) 3 U37122 B, W + + + + adenine nucleotide 2 M57424 + + + translocator 2 (fibroblast) (ANT2) adenine nucleotide 1 J02683 translocator 2 (fibroblast) (ANT2) (non-exact 81%) adenine nucleotide 1 J02683 translocator 2 (fibroblast) (ANT2) (non-exact, 79%) adenine nucleotide 1 J02683 translocator 2 (fibroblast) (ANT2) (non-exact, 86%) adenine nucleotide 3 J03592 + + + + translocator 3 (liver) (ANT3) adenosine deaminase, 6 U18121 + + + RNA-specific (ADAR) adenylate cyclase 3 2 AF033861 + + + + + (ADCY3) adenylate cyclase 7 1 D25538 (ADCY7) adenylate kinase 2 (AK2) 2 U39945 + + + + adenylate kinase 3 (AK3) 1 X60673 (non-exact, 67%) adenylyl cyclase- 28 M98474 T + + associated protein (CAP) adipose differentiation- 1 X97324 + + + related protein; adipophilin (ADFP) ADP-ribosylation factor 1 13 M84326 + + + + (ARF1) ADP-ribosylation factor 3 2 M33384 + + + (ARF3) ADP-ribosylation factor 4 1 M36341 T lymphoma + + + (ARF4) ADP-ribosylation factor 5 1 M57567 + + + + (ARF5) ADP-ribosylation factor 1 L04510 + domain protein 1, 64 kD (ARFD1) ADP-ribosyltransferase 4 M32721 + + + + + + (NAD+; poly (ADP-ribose) polymerase) (ADPRT) adrenergic, beta, receptor 2 X61157 B + + kinase 1 (ADRBK1) adrenoleukodystrophy-like 1 AJ000327 1 (ALDL1) AE-binding protein 1 1 D86479 (AEBP1) (non-exact, 62%) AF-17 1 U07932 A-gamma-globin 1 V00514 A-gamma-globin 1 J00176 (chromosome 11 allele) agammaglobulinaemia 1 U78027 tyrosine kinase (ATK) AHNAK nucleoprotein 4 M80899 + + + + + (desmoyokin) (AHNAK) alanyl (membrane) 1 X13276 + + aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) (ANPEP) alcohol dehydrogenase 5 1 M29872 (class III), chi polypeptide (ADH5) aldehyde dehydrogenase 1 AF003341 + + + 1, soluble (ALDH1) aldehyde dehydrogenase 2 U75286 10 (fatty aldehyde dehydrogenase) (ALDH10) aldehyde reductase 1 (low 3 J04795 B + + + + Km aldose reductase) (ALDR1) aldo-keto reductase family 2 J04794 B + + + 1, member A1 (aldehyde reductase) (AKR1A1) aldo-keto reductase family 1 D17793 + + + + 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3) aldo-keto reductase family 1 Y16675 + + + + 7, member A2 (aflatoxin aldehyde reductase) (AKR7A2) aldolase A, fructose- 7 X12447 + + + bisphosphate (ALDOA) aldolase C, fructose- 2 X05196 + + + bisphosphate (ALDOC) alkaline phosphatase, 1 4502062 liver/bone/kidney (ALPL) ALL-1 (=L04731; L04284 4 Z69780 HRX) alpha mannosidase II 1 D55649 + + isozyme alpha thalassemia/mental 3 U75653 + + + + + retardation syndrome X- linked (ATRX) alpha-2 macroglobulin 1 Z11711 alpha-2-globin 2 V00516 alpha-2-macroglobulin 1 U06985 receptor/lipoprotein receptor protein (A2MR/LRP) alpha-polypeptide of N- 1 M13520 acetyl-alpha- glucosaminidase (HEXA) alpha-spectrin 1 X86901 alpha-subunit of Gi2 a 1 X07854 (GTP-binding signal transduction protein) aminin receptor 1 (67 kD); 2 J03799 T + + + + Ribosomal protein SA (LAMR1) aminolevulinate, delta-, 1 X64467 + dehydratase (ALAD) amino-terminal enhancer of 2 X73358 + + + + + split (AES) amino-terminal enhancer of 3 U04241 B + + + + split (AES) AMP deaminase isoform L 8 M91029 + + (AMPD2) amphiphysin (Stiff-Mann 1 U07616 B + + syndrome with breast cancer 128 kD autoantigen) (AMPH) amphiphysin (Stiff-Mann 1 U07616 syndrome with breast cancer 128 kD autoantigen) (AMPH)(non-exact, 68%) amphiphysin (Stiff-Mann 1 U07616 syndrome with breast cancer 128 kD autoantigen) (AMPH)(non-exact, 68%) amphiphysin II 4 U87558 + + + amphiphysin II (67% aa 1 AF068915 amphiphysin?) amphiphysin II (non-exact 1 AF001383 69% aa) amphiphysin-like (AMPHL) 1 U68485 + + amphiphysin-like (AMPHL) 1 AF068918 (low match) AMY-1 1 D50692 B, T + amyloid beta (A4) 1 L77864 + + + + precursor protein-binding, family B, member 1 (Fe65) (APBB1) amyloid beta (A4) 6 L27631 T lymphoma + + + + precursor-like protein 2 (APLP2) ankyrin 3, node of Ranvier 1 U43965 (ankyrin G) (ANK) (non- exact, 50%) annexin I (lipocortin I) 1 X05908 + + + + (ANX1) annexin II 1 D28364 annexin II (lipocortin II; 7 D00017 + + + + + + high in many libraries calpactin I, heavy polypeptide) (ANX2) annexin IV (placental 1 M19383 + + + + + anticoagulant protein II) (ANX4) annexin V (endonexin II) 2 M21731 + + + + (ANX5) annexin V (endonexin II) 1 M19384 + + + + (ANXV) annexin VI (p68) (ANX6) 6 Y00097 + + + + annexin VII (synexin) 1 J04543 + + + + (ANX7) antigen identified by 2 M16279 + + + + monoclonal antibodies 12E7, F21 and O13 (MIC2) antigen identified by 3 J02939 + + + + + monoclonal antibodies 4F2, TRA1.10, TROP4, and T43 (MDU1) antigen TQ1 1 anti-oxidant protein 2 (non- 1 D14662 + + + + + selenium glutathione peroxidase, acidic calcium- independent phospholipase A2) (KIAA0106) APEX nuclease 5 X66133 + + + + (multifunctional DNA repair enzyme) (APEX) Apolipoprotein L (APOL) 1 Z82215 (59% aa) apoptosis inhibitor 1 (API1) 1 L49431 + + + + + apoptosis inhibitor 4 1 U75285 B, W + + + (survivin) (API4) apoptosis inhibitor 5 (API5) 1 U83857 T lymphoma + + apoptosis specific protein 1 Y11588 B + + + (ASP) apoptotic protease 1 AF013263 B + + + activating factor (APAF1) aquaporin 3 (AQP3) 1 AB001325 T + aquaporin 9 (AQP9) 7 AB008775 T activated + arachidonate 12- 1 M58704 T + + lipoxygenase (ALOX12) arachidonate 5- 3 X52195 + + + + lipoxygenase-activating protein (ALOX5AP) ariadne homolog (ARI) 1 AJ009771 + + + + + ariadne-2 (D. melanogaster) 1 AF099149 + + + + + homolog (all-trans retinoic acid inducible RING finger) (ARI2) ARP1 (actin-related protein 1 X82206 + + 1, yeast) homolog A (centractin alpha) (ACTR1A) ARP2 (actin-related protein 9 AF006082 + + + + 2, yeast) homolog (ACTR2) ARP2/3 protein compex 5 AF006085 T activated, W + + + subunit 34 (ARC34) Arp2/3 protein compex 6 AF006084 monocyte + + + subunit p41 (ARC41) stimulated Arp2/3 protein compex 1 AF006084 subunit p41 (ARC41)) (low match) Arp2/3 protein complex 20 AF017807 + + + + subunit p16 (ARC16) Arp2/3 protein complex 2 AF006087 + + + + subunit p20 (ARC20) Arp2/3 protein complex 3 AF006086 W + + subunit p21(ARC21) ARP3 (actin-related protein 11 AF006083 W + + + 3, yeast) homolog (ACTR3) arrestin, beta 2 (ARRB2) 1 AF106941 B, T, W + + + arsA (bacterial) arsenite 1 AF047469 B, T + + transporter, ATP-binding, homolog 1 (ASNA1) aryl hydrocarbon receptor 2 AF044288 B + + + nuclear translocator-like (ARNTL) aryl hydrocarbon receptor- 1 U31913 + + + + + interacting protein (AIP) arylsulfatase A (ARSA) 1 X52151 T activated + + asialoglycoprotein receptor 1 M11025 + + 2 (ASGR2) asparaginyl-tRNA 3 D84273 + + + synthetase (NARS) aspartyl-tRNA synthetase 1 J05032 B + + + (DARS) ataxia telangiectasia 1 U82828 B, T + + mutated (includes complementation groups A, C and D) (ATM) ataxin-2-like protein A2LP 1 AF034373 B, T + + + (A2LG) activated ATF6 1 AF005887 + + ATP binding cassette 1 U88667 transporter (ABCR) (non- exact 80%) ATP synthase (F1-ATPase) 1 X59066 alpha subunit, mitochondrial ATP synthase beta subunit 1 M19482 gene ATP synthase, H+ 1 X60221 + + + + + transporting, mitochondrial F0 complex, subunit b, isoform 1 (ATP5F1) ATP synthase, H+ 1 X69907 T activated + + + + transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 (ATP5G1) ATP synthase, H+ 3 D14710 transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle (ATP5A1) ATP synthase, H+ 1 D14710 transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle (ATP5A1) (low match) ATP synthase, H+ 2 M27132 transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) ATP synthase, H+ 1 D16563 W + + + + transporting, mitochondrial F1 complex, gamma polypeptide 1 (ATP5C1) ATP synthase, H+ 1 AF092124 + + + + + + transporting, mitochondrial F1F0, subunit g (ATP5JG) ATP/GTP-binding protein 2 U73524 + + + + + (HEAB) ATPase, Ca++ 5 Z69881 + transporting, ubiquitous (ATP2A3) ATPase, H+ transporting, 2 D89052 + + + + + lysosomal (vacuolar proton pump) 21 kD (ATP6F) ATPase, H+ transporting, 1 X76228 + + + + lysosomal (vacuolar proton pump) 31 kD (ATP6E) ATPase, H+ transporting, 5 X69151 + + + + lysosomal (vacuolar proton pump) 42 kD; Vacuolar proton-ATPase, subunit C; V-ATPase, subunit C (ATP6D) ATPase, H+ transporting, 3 L09235 + + lysosomal (vacuolar proton pump), alpha polypeptide, 70 kD, isoform 1 (ATP6A1) ATPase, H+ transporting, 6 X62949 + + + + + lysosomal (vacuolar proton pump), beta polypeptide, 56/58 kD, isoform 2 (ATP6B2) ATPase, H+ transporting, 2 AF038954 + + + + + high in testis lysosomal (vacuolar proton pump), member J (ATP6J) ATPase, H+ transporting, 1 D16469 + + + + lysosomal (vacuolar proton pump), subunit 1 (ATP6S1) ATP-binding cassette 50 1 AF027302 + + + + + (TNF-alpha stimulated) (ABC50) ATP-binding cassette 1 AF047690 protein M-ABC1 (mitochondrial) ATP-dependent RNA 1 AJ010840 T lymphoma + + helicase autoantigen (Hs.75528) 2 L05425 T activated + autoantigen (Hs.75528) 1 L05425 (non-exact 84%) autoantigen (Hs.75682) 1 U17474 B + + autoantigen La/SS-B 1 Z35127 axin (AXIN1) 1 AF009674 T + axonemal dynein heavy 1 AJ000522 + chain (DNAH17) BAI1-associated protein 3 1 AB017111 (BAIAP3) (non-exact 54%) basement membrane- 1 AF044896 induced gene (ICB1) basic leucine zipper 2 U79751 nuclear factor 1 (JEM-1) (BLZF1) basic transcription factor 3 5 X74070 + + + + + + (BTF3) basigin (BSG) 1 L10240 + + BC-2 1 AF042384 B + + + B-cell CLL/lymphoma 6 1 U00115 + + (zinc finger protein 51) (BCL6) B-cell translocation gene 1, 1 X61123 + + anti-proliferative (BTG) BCL2/adenovirus E1B 1 U15173 B + + + 19 kD-interacting protein 2 (BNIP2) BCL2/adenovirus E1B 2 AF067396 + + + + 19 kD-interacting protein 3- like (BNIP3L) beclin 1 (coiled-coil, 1 AF077301 B + + + myosin-like BCL2- interacting protein) (BECN1) beta-1,2-N- 2 U15128 acetylglucosaminyltransferase II (MGAT2) beta-2-microglobulin (B2M) 63 S82297 + + + + + + high in invasive prostate tumor beta-hexosaminidase alpha 1 M16411 chain (HEXA) beta-tubulin 7 V00599 + + + + + + high in many libraries beta-tubulin (non-exact, 1 AF070561 76%) beta-tubulin, pseudogene 1 J00315 BING4 1 Z97184 biotinidase (BTD) (non-eact 1 U03274 62%) biotinidase (BTD) (non- 1 U03274 exact 70%) biotinidase (BTD) (non- 1 U03274 exact, 56%) BIOTINIDASE 1 P43251 PRECURSOR biphenyl hydrolase-like 1 X81372 + + (serine hydrolase) (BPHL) bone marrow stromal cell 1 D21878 + antigen 1 (BST1) box-dependent myc- 1 AF043900 interacting protein isoform BIN1-10 (BIN1) box-dependent myc- 1 AF043900 interacting protein isoform BIN1-10 (BIN1) (non-exact, 64%) brain my047 protein 1 AF063605 T + + + branched chain keto acid 3 Z14093 T + + + dehydrogenase E1, alpha polypeptide (maple syrup urine disease) (BCKDHA) BRCA1 associated protein- 1 D87462 + + + + 1 (ubiquitin carboxy- terminal hydrolase) (BAP1) BRCA1, Rho7 and vatl 1 L78833 genes, and ipf35 breakpoint cluster region 2 AF044773 + + protein, uterine leiomyoma, 1; barrier to autointegration factor (BCRP1) breakpoint cluster region 2 AF044774 + + + + protein, uterine leiomyoma, 2 (BCRP2) breast cancer anti-estrogen 1 U92715 resistance 3 (BCAR3) (non-exact 73%) bromodomain-containing 2 M91585 + protein, 140 kD (peregrin) (BR140) Bruton's 1 U13424 agammaglobulinemia tyrosine kinase (Btk) Bruton's tyrosine kinase 1 U78027 (BTK) Bruton's tyrosine kinase 1 U78027 (BTK), alpha-D- galactosidase A (GLA), L44-like ribosomal protein (L44L) and FTP3 (FTP3) BS4 1 AF108083 BTG2 (BTG2) 6 Y09943 + + + + + BTK region clone ftp 1 U78027 + + + + + BTK region clone ftp-3 1 U01923 + + + BUB3 (budding uninhibited 4 AF053304 + + + + + by benzimidazoles 3, yeast) homolog (BUB3) butyrate response factor 1 4 X79067 + + + + + (EGF-response factor 1) (BRF1) butyrophilin (BTF1) 7 U90543 + + + butyrophilin like receptor 1 AB020625.1 CAG repeat containing 2 U80744 + + (CTG4A) CAGH32 2 U80743 + + + calcium channel, voltage- 1 M83566 dependent, L type, alpha 1D subunit (CACNA1D) (low match) calcium/calmodulin- 1 AF069765 + + + + dependent protein kinase (CaM kinase) II gamma (CAMK2G) calcium/calmodulin- 1 AF101264 B + + + dependent protein kinase kinase (KIAA0787) calmodulin (=M19311) 7 D45887 calmodulin 1 6 M27319 B + + + + (phosphorylase kinase, delta) (CALM1) calnexin (CANX) 3 M94859 T + + + calpain, large polypeptide 5 X04366 + + + + L1 (CAPN1) calpain, large polypeptide 5 M23254 + + L2 (CANP2) calpain, small polypeptide 1 X04106 + + + + (CAPN4) calpastatin (CAST) 3 D16217 + Calponin 2 2 D83735 + + + calponin 2 (CNN2) 1 D83735 B, T + + calponin 2 (CNN2) (low 1 D83735 score) calumenin (CALU) 3 AF013759 B + + + cAMP response element- 4 L05912 binding protein CRE-Bpa (H_GS165L15.1) cAMP-dependent protein 1 M90360 kinase type II (Ht31) canicular multispecific 1 AF009670 + + + organic anion transporter (CMOAT2) capping protein (actin 6 U56637 B, T + + filament) muscle Z-line, alpha 1 (CAPZA1) capping protein (actin 2 U03269 B + + filament) muscle Z-line, alpha 2 (CAPZA2) capping protein (actin 1 U03271 + + + + + filament) muscle Z-line, beta (CAPZB) capping protein (actin 8 M94345 + + + + filament), gelsolin-like (CAPG) carbamoyl-phosphate 1 D78586 + + + + + synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) carbonic anhydrase V, 1 L19297 + + mitochondrial (CA5) carboxypeptidase D (CPD) 3 U65090 B + + carnitine/acylcarnitine 1 Y10319 + + + translocase (CACT) Cas-Br-M (murine) 2 X57110 + ecotropic retroviral transforming sequence (cbl) casein kinase 1, alpha 1 1 L37042 + + + + + (CSNK1A1) casein kinase 2, alpha 1 2 M55265 B + + + polypeptide (CSNK2A1) casein kinase I gamma 3L 1 AF049090.1 (CSNK1G3L) casein kinase II alpha 1 X69951 subunit(=S72393) CASP8 and FADD-like 4 AF015450 + + + + + apoptosis regulator (CFLAR) caspase 1, apoptosis- 7 U13697 + + related cysteine protease (interleukin 1, beta, convertase) (CASP1) caspase 10, apoptosis- 1 U60519 B, T + related cysteine proteas activated, T (CASP10) lymphoma caspase 3, apoptosis- 3 U13737 B, T + + + + related cysteine protease (CASP3) caspase 4, apoptosis- 6 U25804 + + + + + related cysteine protease (CASP4) caspase 5, apoptosis- 1 U28015 + related cysteine protease (CASP5) caspase 8, apoptosis- 2 X98173 + + + related cysteine protease (CASP8) caspase 9, apoptosis- 1 U56390 B + + related cysteine protease (CASP9) catalase (CAT) 5 X04076 B + + + catechol-O- 1 M65213 + + + methyltransferase (COMT) catenin (cadherin- 6 D14705 + + associated protein), alpha 1 (102 kD) (CTNNA1) cathelicidin antimicrobial 1 X89658 B peptide (CAMP) cathepsin B (CTSB) 4 L16510 + + + cathepsin C (CTSC) 3 U79415 + + + + cathepsin D (lysosomal 4 M11233 + + + aspartyl protease) (CTSD) cathepsin E (CTSE) 1 J05036 + cathepsin G (CTSG) 1 M16117 T, W + cathepsin S (CTSS) 34 M86553 B, Monocyte + + stimulated, T lymphoma cathepsin W (lymphopain) 4 AF013611 + (CTSW) CBF1 interacting 1 AF098297 corepressor CIR (=U03644 recepin) CCAAT/enhancer binding 3 X87248 + + + + protein (C/EBP), alpha (CEBPA) CCAAT/enhancer binding 1 S63168 + + + protein (C/EBP), delta (CEBPB) CCAAT-box-binding 2 M37197 T lymphoma + + transcription factor (CBF2) CCR5 receptor (CCR5) 1 AF011504 (non-exact?) CD14 antigen (CD14) 11 M86511 + + + + + CD18 (=M95293) 4 X64071 CD1C antigen, c 2 M28827 + polypeptide (CD1C) CD2 antigen (cytoplasmic 1 AF104222 tail)-binding protein 2 (CD2BP2) CD2 antigen (p50), sheep 4 M14362 + + + + red blood cell receptor (CD2) CD2 cytoplasmic tail- 2 AF038602 + binding protein 1 (CD2BP1) CD20 antigen (CD20) 1 X12530 CD20 receptor (S7) 1 X07203 CD22 antigen (CD22) 1 U62631 B CD24 signal transducer 1 M58664 CD33 antigen (gp67) 1 M23197 + (CD33) CD33 antigen-like 2; OB 1 U71383 binding protein-2 (CD33L2) (non-exact, 68%) CD33L2 (61% aa) 1 D86359 CD36 antigen (collagen 7 M98398 T lymphoma + + + type I receptor, thrombospondin receptor) (CD36) CD37 antigen (CD37) 5 X14046 + + + + CD38 alt 1 D84277 CD39 antigen (CD39) 1 U87967 B + + + CD3D antigen, delta 1 X03934 + + + polypeptide (TiT3 complex) (CD3D) CD3E antigen, epsilon 1 X03884 + + polypeptide (TiT3 complex) (CD3E) CD3G antigen, gamma 2 X06026 W + polypeptide (TiT3 complex) (CD3G) CD3Z antigen, zeta 2 J04132 + + polypeptide (TiT3 complex) (CD3Z) CD3-zeta (clone pBS NK1) 1 X55510 CD4 (low match) 1 S68043 CD4 antigen (p55) (CD4) 4 M12807 + + + CD44 antigen (homing 6 X56794 W + + function and Indian blood group system (CD44) CD48 antigen (B-cell 3 X06341 + + + + + membrane protein) (CD48) CD53 antigen (CD53) 10 L11670 + + + + CD53 antigen (CD53) (low 1 M60871 match) CD63 antigen (melanoma 1 3 M59907 antigen) (CD63) CD68 antigen (CD68) 2 S57235 + + + + CD74 antigen (invariant 72 K01144 + + + + + + high in many libraries polypeptide of major histocompatibility complex, class II antigen-associated) (CD74) CD79A antigen 2 M80462 + (immunoglobulin- associated alpha) (CD79A) CD79B antigen 2 M89957 + (immunoglobulin- associated beta) (CD79B) CD8 antigen, alpha 2 M27161 + + + polypeptide (p32) (CD8A) CD8 antigen, beta 1 X13445 W polypeptide 1 (p37) (CD8B1) CD81 antigen (target of 1 M33680 + + + antiproliferative antibody 1 (CD81) CD83 antigen (activated B 1 Q01151 B + + + lymphocytes, mmunoglobulin superfamily) (CD83) CD84 antigen (leukocyte 1 U82988 + + + antigen) (CD84) CD86 antigen 1 L25259 + CD9 antigen (p24) (CD9) 2 M38690 + + + CD97 antigen (CD97) 12 X84700 + + + CD97 antigen (CD97) 1 P48960 (noin-exact 59%) CD97 antigen (CD97) (non- 1 X94630 + + + exact 62%) CDC23 (cell division cycle 1 AF053977 + + + 23, yeast, homolog) (CDC23) CDC37 homolog 1 U63131 B + + + + Cdc42 effector protein 3 2 AF104857 B + + + (CEP3) CDC-like kinase (CLK) 1 L29219 + + + + CDC-like kinase 2 (CLK2) 1 AF023268 B + + CDW52 antigen 13 X15183 T activated + + + (CAMPATH-1 antigen) (CDW52) cell cycle progression 1 AF011794 restoration 8 protein(CPR8) cell division cycle 10 4 S72008 + + + + + (homologous to CDC10 of S. cerevisiae) (CDC10) cell division cycle 20, 1 U05340 + + + S. cerevisiae homolog (CDC20) cell division cycle 25B 6 Z68092 + + + + + (CDC25B) cell division cycle 2-like 1 1 AF067514 (PITSLRE proteins) (CDC2L1) (non-exact 42%) cell division cycle 42 (GTP- 5 M35543 + + + + + binding protein, 25 kD) (CDC42) cell division protein (non- 1 AF063015 exact 68%) CELL-CYCLE NUCLEAR 1 Q13033 AUTOANTIGEN SG2NA (S/G2 NUCLEAR ANTIGEN) centromere protein B 1 X55039 + + (80 kD) (CENPB) cep250 centrosome 3 AF022655 B + + associated protein ceroid-lipofuscinosis, 7 AF017456 + + + + + + high in bone neuronal 2, late infantile (Jansky-Bielschowsky disease) (CLN2) c-fgr (=M63877 6 X52206 nonreceptor protein- tyrosine kinase (fgr)) CGI-19 protein 3 AF132953.1 chaperonin containing 1 X74801 + + + TCP1, subunit 3 (gamma) (CCT3) chaperonin containing 1 AF026291 + + + + TCP1, subunit 4 (delta) (CCT4) chaperonin containing 4 L27706 B + + TCP1, subunit 6A (zeta 1) (CCT6A) chaperonin containing 4 AF026292 B + + TCP1, subunit 7 (eta) (CCT7) Chediak-Higashi syndrome 1 U67615 B, T + + + 1 (CHS1) lymphoma Chediak-Higashi syndrome 1 U67615 1 (CHS1) (low score) chemokine (C-C motif) 4 U03905 receptor 2 (CCR2) chemokine (C-C motif) 1 X85740 receptor 4 (CCR4) (low match) (may contain repeat) chemokine (C-C motif) 6 L31581 receptor 7 (CCR7) chemokine (C—X3—C) 5 U20350 + receptor 1 (CX3CR1) chemokine (C—X—C motif), 5 M99293 + + + + + receptor 4 (fusin) (CXCR4) chitinase 3-like 1 (cartilage 2 M80927 + + + glycoprotein-39) (CHI3L1) chitinase 3-like 2 (CHI3L2) 2 U49835 + + + chloride channel 1, 1 G18280 skeletal muscle (CLCN1) chloride channel 6 1 D28475 + + (CLCN6) Chloride intracellular 1 U93205 + + + + + channel 1 (CLIC1) chondroitin sulfate 5 X15998 + proteoglycan 2 (versican) (CSPG2) chondroitin sulfate 2 J02814 + + proteoglycan core protein chromatin assembly factor 1 Q09028 1 p48 subunit (CAF-1 P48 subunit) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (MSI1 protein homolog) chromodomain helicase 2 AF006513 DNA binding protein 1 (CHD1) chromodomain helicase 1 AF054177 DNA binding protein 1-like (CHD1L) chromodomain helicase 1 AF006514 B + + + DNA binding protein 2 (CHD2) chromodomain helicase 1 AF006515 DNA binding protein 3 (CHD3) chromodomain helicase 5 X86691 + + + + + DNA binding protein 4 (CHD4) chromosome 1 open 1 AF054176 reading frame 7 (C1ORF7) chromosome 1 specific 1 AB007962 transcript KIAA0493 chromosome 17 open 1 AJ008112 T + reading frame 1B (C17ORF1B) chromosome 4 open 1 AF006621 + + + + reading frame 1 (C4ORF1) chromosome condensation 2 AF060219 + + + + 1-like (CHC1L) chromosome X open 1 Y15164 B + + + reading frame 5 (CXORF5) chromosome-associated 2 AF092564 B + + + + polypeptide C(CAP-C) cig42 1 AF026944 cig5 3 AF026941 citrate synthase (CS) 2 AF047042 B + + + + class I major 2 U31372 histocompatibility antigen (HLA-Cw3) class I major 1 U31372 histocompatibility antigen (HLA-Cw3) (low match) clathrin assembly protein 3 U45976 B + + + lymphoid myeloid leukemia (CALM) clathrin heavy chain 1 X55878 clathrin, heavy polypeptide- 1 D21260 like 2 (CLTCL2) clathrin, light polypeptide 1 M20472 (Lca) (CLTA) (low match) clathrin- 3 D63475 + + + + + associated/assembly/adaptor protein, medium 1 (CLAPM1) cleavage stimulation factor, 1 M85085 3′ pre-RNA, subunit 2 64 kD (CSTF2) (non-exact 82%) cleavage stimulation factor, 1 U15782 B + + + 3′ pre-RNA, subunit 3, 77 kD (CSTF3) clk3 1 L29220 B + + clone 23815 (Hs.82845) 1 U90916 + + + clone 24592 mRNA 1 D88378 + + + + + sequence Clq/MBL/SPA receptor 1 U94333 C1qR(p) ( ) clusterin (complement lysis 1 M64722 + + + + + + inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) (CLU) CMP-sialic acid transporter 1 D87969 B + + (CMPST) CMRF35 3 X66171 c-myc oncogene containing 1 X54629 coxIII coagulation factor II 1 M62424 + + + (thrombin) receptor (F2R) coagulation factor V 1 M14335 + + + (proaccelerin, labile factor) (F5) coagulation factor XIII a 3 M21998 subunit coagulation factor XIII, A1 6 M14354 + + + + polypeptide (F13A1) coated vesicle membrane 1 X92098 + + + + + + protein (RNP24) coatomer protein complex, 5 U24105 T + + subunit alpha (COPA) Cofilin 1 (non-muscle) 13 X95404 + + + + + + high in fetal brain (CFL1) cold inducible RNA-binding 7 D78134 + + + protein (CIRBP) cold shock domain protein 3 X95325 + + A (CSDA) collagen, type IX, alpha 2 3 AF019406 B (COL9A2) colony stimulating factor 1 3 X03663 + + + receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog (CSF1R) colony stimulating factor 2 5 M59941 receptor, beta, low-affinity (granulocyte-macrophage) (CSF2RB) colony stimulating factor 2 1 M59941 receptor, beta, low-affinity (granulocyte-macrophage) (CSF2RB) (low match) colony stimulating factor 3 16 X55720 + receptor (granulocyte) (CSF3R) complement component 5 1 M62505 L receptor 1 (C5a ligand) (C5R1) conserved gene amplified 2 AF000152 + + + + in osteosarcoma (OS4) COP9 (constitutive 2 AF031647 + + + photomorphogenic, Arabidopsis, homolog) subunit 3 (COPS3) COP9 homolog (HCOP9) 2 U51205 B + + + + + COPII protein, homolog of 4 X97064 + + s. cerevisiae SEC23p (SEC23A) copine I (CPNE1) 2 U83246 B + + + copine I (CPNE1) (low 1 U83246 score) coproporphyrinogen 1 D16611 + + + oxidase (coproporphyria, harderoporphyria) (CPO) core-binding factor, beta 1 L20298 + subunit (CBFB) coronin 22 X89109 T, W + + + coronin (low match) 1 U34690 coronin (non-exact, 71%) 1 X89109 cot (cancer Osaka thyroid) 1 D14497 + + + + + oncogene (COT) cryptochrome 1 1 D84657 + + + (photolyase-like) (CRY1) CTD (carboxy-terminal 1 AF081287 + + + + domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (CTDP1) C-terminal binding protein 1 U37408 B + + + 1 (CTBP1) C-terminal binding protein 2 AF016507 + + + 2 (CTBP2) CUG triplet repeat, RNA- 3 U63289 + + + + binding protein 1 (CUGBP1) cullin 1 (CUL1) 3 U58087 + + + + cullin 3 (CUL3) 2 U58089 + + + + cut (Drosophila)-like 1 1 M74099 B + (CCAAT displacement protein) (CUTL1) cyclin D2 (CCND2) 2 D13639 + + + + cyclin D3 (CCND3) 5 M92287 B, T + + lymphoma cyclin G1 (CNNG1) 1 D78341 B + + + cyclin I 3 D50310 B + + cyclin T2 (CNNT2) 1 AF048732 B, T B lymphoma cyclin-dependent kinase 2 1 X62071 (CDK2) cyclin-dependent kinase 1 S76986 inhibitor (p27Kip1) cyclin-dependent kinase 2 S67388 + + + + + + inhibitor 1A (p21, Cip1) (CDKN1A) CYP2D7-CYP2D6 1 X90926 intergenic region (partial) cystatin B (stefin B) (CSTB) 1 L03558 + + + cysteine and glycine-rich 5 L54057 + protein 3 (cardiac LIM protein) (CSRP3) cytidine deaminase (CDA) 2 L27943 + cytochrome b 1 AF042500 cytochrome b (CYTB) 1 AF042518 (isolate Aus5) cytochrome b(-245) beta 2 X05895 chain N-terminal region (X- linked granulomatous disease gene) cytochrome b-245, beta 2 X04011 + + + polypeptide (chronic granulomatous disease) (CYBB) cytochrome C 1 P00001 cytochrome c oxidase 1 U90915 T + + + + subunit IV (COX4) cytochrome c oxidase 2 M59250 + subunit Vb (COX5B) cytochrome c oxidase 6 AB007618 + + + + + subunit VII-related protein (COX7RP) cytokine suppressive anti- 1 L35263 lymphocyte + + + inflammatory drug binding protein 1 (p38 MAP kinase) (CSBP1) Cytoplasmic 1 S69272 + antiproteinase = 38 kda intracellular serine proteinase inhibitor cytotoxic granule- 1 S70114 associated RNA-binding protein p40-TIA-1 D123 (D123) 1 D14878 + + + + D2-2 1 AF019226 D38 1 X74802 damage-specific DNA 2 AJ002955 + + + + + + binding protein 1 (127 kD) (DDB1) DCHT (low match) 1 AF017635 DEAD/H (Asp-Glu-Ala- 1 U78524 + + + + + Asp/His) box binding protein 1 (DDXBP1) DEAD/H (Asp-Glu-Ala- 2 U59321 T + + + + Asp/His) box polypeptide (72 KD) (P72) DEAD/H (Asp-Glu-Ala- 1 X70649 + + + Asp/His) box polypeptide 1 (DDX1) DEAD/H (Asp-Glu-Ala- 2 AB001636 Asp/His) box polypeptide 15 (DDX15) DEAD/H (Asp-Glu-Ala- 2 AB011149 + + + + + Asp/His) box polypeptide 16 (DDX16) DEAD/H (Asp-Glu-Ala- 3 U50553 + + + + + Asp/His) box polypeptide 3 (DDX3) DEAD/H (Asp-Glu-Ala- 37 X15729 + + + + + Asp/His) box polypeptide 5 (RNA helicase, 68 kD) (DDX5) DEAD/H (Asp-Glu-Ala- 1 AF015812 Asp/His) box polypeptide 5 (RNA helicase, 68 kD) (DDX5) (low match) DEAD/H (Asp-Glu-Ala- 2 D17532 + + Asp/His) box polypeptide 6 (RNA helicase, 54 kD) (DDX6) DEAD/H (Asp-Glu-Ala- 1 D50487 + + + + Asp/His) box polypeptide 8 (RNA helicase, 54 kD) (DDX8) DEAD/H (Asp-Glu-Ala- 3 L13848 + + + + + Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA helicase II; leukophysin) (DDX9) DEAD/H (Asp-Glu-Ala- 1 AF000985 + + + Asp/His) box polypeptide, Y chromosome (DBY) Death associated protein 3 2 X83544 + + + + + + (DAP3) death effector domain- 1 AF083236 + + + + containing protein (DEDD) death-associated protein 6 2 AF039136 + + + + (DAXX) dedicator of cyto-kinesis 2 4 D86964 + + + + (DOCK2) defender against cell death 1 D15057 + + + 1 (DAD1) Defensin, alpha 1, myeloid- 4 L12690 + + + related sequence (DEFA1) DEK gene (D6S231E) 1 X64229 B + + delta sleep inducing 4 Z50781 + + + + + peptide, immunoreactor (DSIPI) dendritic cell protein 3 AF064603 + + + + + (GA17) deoxycytidine kinase (DCK) 1 M60527 deoxyribonuclease II, 3 AB004574 lysosomal (DNASE2) DGS-I 2 L77566 + diacylglycerol kinase 3 D16440 diacylglycerol kinase alpha 3 AF064771 + (DAGK1) (clone 24) diacylglycerol kinase alpha 1 AF064771 (DAGK1) (clone 24) (low match) diaphanous (Drosophila, 1 AF051782 B, monocyte + + + + homolog) 1 (DIAPH1) stimulated diaphorase (NADH) 1 Y09501 + + + + + + (cytochrome b-5 reductase) (DIA1) differentiated Embryo 1 AB004066 + + + Chondrocyte expressed gene 1 (DEC1) differentiated Embryo 1 AB004066 Chondrocyte expressed gene 1 (DEC1) (low match) differentiation antigen 1 L23415 CD20 DiGeorge syndrome critical 1 X84076 + + + region gene 2 (DGCR2) dihydrolipoamide 2 J03620 + + + dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) (DLD) dihydrolipoamide S- 1 Y00978 B + + acetyltransferase (E2 component of pyruvate dehydrogenase complex) (DLAT) dihydropyrimidinase-like 2 1 D78013 + + + + (DPYSL2) dinG gene 1 Y10571 diptheria toxin resistance 3 AF053003 B + + + + protein required for diphthamide biosynthesis (Saccharomyces)-like 2 (DPH2L2) disintegrin-protease (non- 1 Y13323 exact 72%) DJ-1 protein 2 AF021819 + + + + + Dmx-like 1 (DMXL1) 1 AJ005821 + + + DNA (cytosine-5-)- 3 X63692 T activated, + + + methyltransferase 1 lymphoma (DNMT1) DNA fragmentation factor, 1 AF064019 40 kD, beta subunit (DFFB) DNA fragmentation factor, 2 U91985 T + + + 45 kD, alpha subunit (DFFA) DNA mismatch repair 1 U17840 protein (hMLH1) DNA segment on 3 M64241 + + + + + + high in many libraries chromosome X (unique) 648 expressed sequence DNA segment, single copy 3 M73547 + + + + probe LNS-CAI/LNS-CAII (deleted in polyposis (D5S346) DNA-damage-inducible 1 L24498 transcript 1 (DDIT1) (low match) DnaJ protein 1 AJ001309 DnaJ protein 1 AJ001309 docking protein 2, 56 kD 1 AF034970 (DOK2) dolichyl- 1 D89060 + + + + + + activated T cell diphosphooligosaccharide- protein glycosyltransferase (DDOST) dolichyl-phosphate 1 D86198 T activated + + + mannosyltransferase polypeptide 1, catalytic subunit (DPM1) down-regulated by 1 AJ223183 + activation (immunoglobulin superfamily) (DORA) down-regulated in 1 P40879 adenoma DRA (low match) D-type cyclin-interacting 1 AF082569 B + + protein 1 (DIP1) dual specificity 4 X68277 + + + + + + phosphatase 1 (DUSP1) dual specificity 1 AF023917 + + + + + phosphatase 11 (RNA/RNP complex 1-interacting) (dusp11) dual specificity 1 L05147 + + + + phosphatase 3 (vaccinia virus phosphatase VH1- related) (DUSP3) dual specificity 6 X93920 + + + + + + phosphatase 6 (DUSP6) dynactin 1 (p150, Glued 3 X98801 (Drosophila) homolog) (DYTN1) dynactin 1 (p150, Glued 1 X98801 B + + (Drosophila) homolog) (DYTN1) (low match) dynamin 2 (DNM2) 1 L36983 dynamitin (dynactin 1 U50733 complex 50 kD subunit) (DCTN-50) (non-exact 88%) dynein, axonemal, heavy 1 X99947 polypeptide 17-like (non- exact, 57% aa) dynein, cytoplasmic, light 1 AF035812 B + + + intermediate polypeptide 2 (DNCLI2) dynein, cytoplasmic, light 1 AF035812 intermediate polypeptide 2 (DNCLI2) (non-exact, 69%) dyskeratosis congenita 1, 1 U59151 B + + + dyskerin (DKC1) dystonia 1, torsion 1 AF007871 + + + + (autosomal dominant) (DYT1) dystrobrevin, beta (DTNB) 1 AF022728 + dystrophia myotonica- 1 L19267 + + + + containing WD repeat motif (DMWD) dystrophia myotonica- 1 L08835 + + + + protein kinase (DMPK) dystrophin (muscular 1 X14298 dystrophy, Duchenne and Becker types) (DMD) (low match, 59% aa) E1B-55 kDa-associated 1 AJ007509 W + + + + protein E2F transcription factor 3 2 D38550 + + + + + (E2F3) E2F transcription factor 4, 1 X86096 B + + p107/p130-binding (E2F4) E2F transcription factor 5, 2 U15642 + + + + p130-binding (E2F5) E74-like factor 1 (ets 1 M82882 B + + + domain transcription factor) (ELF1) E74-like factor 4 (ets 3 U32645 + + + domain transcription factor) (ELF4) E74-like factor 4 (ets 1 U32645 domain transcription factor) (ELF4) (non-exact, 71%) early development 4 U89278 + + + + + regulator 2 (homolog of polyhomeotic 2) (EDR2) EBV induced G-protein 1 L08177 W coupled receptor (EBI2) ecotropic viral integration 3 M60830 + + site 2B (EVI2B) ectin, galactoside-binding, 1 J04456 + soluble, 1 (galectin 1) (LGALS1) EGF-like-domain, multiple 1 AB011541 4 (EGFL4) elF-2-associated p67 3 U13261 B + + homolog elastin (supravalvular aortic 1 M24782 + + stenosis, Williams-Beuren syndrome) (ELN) (low match) elav-type RNA-binding 3 U69546 protein (ETR-3) electron-transfer- 2 J04058 + flavoprotein, alpha polypeptide (glutaric aciduria II) (ETFA) ELK3, ETS-domain protein 2 Z36715 + + (SRF accessory protein 2) (ELK3) elongation factor 1-beta 1 L26404 elongation factor Ts 1 AF110399 (mitochondrial protein) elongation factor Tu- 1 X84694 nuclear encoded mitochondrial eMDC II protein 1 AJ242015.1 ems1 sequence (mammary 1 M98343 + + + + tumor and squamous cell carcinoma-associated (p80/85 src substrate) (EMS1) endogenous retroviral 1 Z70664 element HC2 endosulfine alpha (ENSA) 1 X99906 T + endothelial differentiation, 2 M31210 + + + + sphingolipid G-protein- coupled receptor, 1 (EDG1) endothelial differentiation, 1 M31210 sphingolipid G-protein- coupled receptor, 1 (EDG1) (low match 66%) endothelial monocyte- 1 U10117 + + + + + activating polypeptide (EMAPII) enolase 1, (alpha) (ENO1) 12 M14328 + + + + + + enolase 2, (gamma, 1 X51956 + neuronal) (ENO2) enolase-alpha 1 D28437 enoyl Coenzyme A 2 U16660 hydratase 1, peroxisomal (ECH1) enoyl Coenzyme A 1 D13900 + + + + + + hydratase, short chain, 1, mitochondrial (ECHS1) ENOYL-COA 1 P30084 HYDRATASE, MITOCHONDRIAL PRECURSOR (SHORT CHAIN ENOYL-COA HYDRATASE) (SCEH) (ENOYL-COA HYDRATASE 1) (low match, non-exact 56%) epidermal growth factor 2 U07707 + + + receptor pathway substrate 15 (EPS15) EPIDIDYMAL 2 Q15668 SECRETORY PROTEIN E1 PRECURSOR (EPI-1) (HE1) (EPIDIDYMAL SECRETORY PROTEIN 14.6) (ESP14.6) epithelial membrane 1 U87947 + + + + + protein 3 (EM[P3) Epoxide hydrolase 1, 1 L29766 + microsomal (xenobiotic) only (EPHX1) ERCC2 (=L47234) 1 X52221 ERF-2 3 U07802 + + + + + high in gall bladder ERp28 protein 1 X94910 + + + + + erythrocyte membrane 2 M81635 protein erythroleukemic cells K562 2 L25343 EST (Hs.189509) 2 U24166 estrogen receptor-related 1 L38487 protein (hERRa1) ESTs, Highly similar to 1 X66503 B, T + + ADENYLOSUCCINATE SYNTHETASE ESTs, Moderately similar to 1 U28811 + + + + + cysteine-rich fibroblast growth factor receptor ET binding factor 1 (SBF1) 1 U93181 + + + ets domain protein ERF 1 U15655 + + + + + eukaryotic translation 326 X03558 T + + + elongation factor 1 alpha 1 (EEF1A1) eukaryotic translation 1 X03558 elongation factor 1 alpha 1 (EEF1A1) (low match) eukaryotic translation 1 X03558 elongation factor 1 alpha 1 (EEF1A1) (low match) eukaryotic translation 5 X60489 + + + + + elongation factor 1 beta 2 (EEF1B2) eukaryotic translation 1 Z21507 + + + + + + elongation factor 1 delta (guanine nucleotide exchange protein) (EEF1D) eukaryotic translation 31 Z11531 elongation factor 1 gamma (EEF1G) eukaryotic translation 2 X51466 + + elongation factor 2 (EEF2) eukaryotic translation 1 J02645 initiation factor 2, subunit 1 (alpha, 35 kD) (EIF2S1) eukaryotic translation 1 M29536 initiation factor 2, subunit 2 (beta, 38 kD) (EIF2S2) eukaryotic translation 3 L19161 + + initiation factor 2, subunit 3 (gamma, 52 kD) (EIF2S3) eukaryotic translation 2 U78311 initiation factor 3, subunit 10 (theta, 150/170 kD) (EIF3S10) eukaryotic translation 3 U36764 + + + + + + high in white blood initiation factor 3, subunit 2 cells (beta, 36 kD) (EIF3S2) eukaryotic translation 6 U54559 + + + + + high in spleen initiation factor 3, subunit 3 (gamma, 40 kD) (EIF3S3) eukaryotic translation 9 AF020833 + + + + initiation factor 3, subunit 4 (delta, 44 kD) (EIF3S4) eukaryotic translation 4 U94175 + + + + + high in bladder initiation factor 3, subunit 6 (48 kD) (EIF3S6) eukaryotic translation 1 U62962 + + + + Highly represented initiation factor 3, subunit 6 (1.4833 pct) in library (EIF3S6) 36 human gall bladder eukaryotic translation 3 U54558 + + + + + initiation factor 3, subunit 7 (zeta, 66/67 kD) (EIF3S7) eukaryotic translation 5 U46025 + + + + + + high in testis initiation factor 3, subunit 8, 110 KD (EIF3S8) eukaryotic translation 1 AF012088 initiation factor 4 gamma, 1 (EIF4G) eukaryotic translation 1 AF012088 initiation factor 4 gamma, 1 (EIF4G) (low match) eukaryotic translation 2 D12686 initiation factor 4 gamma, 1 (EIF4G1) eukaryotic translation 6 U73824 + + + + + + initiation factor 4 gamma, 2 (EIF4G2) eukaryotic translation 2 U76111 + + + + + + initiation factor 4 gamma, 2 (EIFG2) eukaryotic translation 29 D13748 initiation factor 4A, isoform 1 (EIF4A1) eukaryotic translation 11 D30655 + + + + + + initiation factor 4A, isoform 2 (EIF4A2) eukaryotic translation 18 X55733 + + + + + initiation factor 4B (EIF4B) eukaryotic translation 1 P06730 initiation factor 4E (EIF4E) Eukaryotic translation 3 L36056 T, B + + + initiation factor 4E binding protein 2 (EIF4EBP2) eukaryotic translation 2 Q15056 initiation factor 4H (EIF4H) eukaryotic translation 2 U49436 + + + + + + initiation factor 5 (EIF5) eukaryotic translation 2 U90176 + + + + + termination factor 1 (ETF1) EV12 protein 1 M55266 + Ewing sarcoma breakpoint 1 X66899 + + + + + region 1 (EWSR1) EWS/FLI1 activated 2 AF020264 transcript 2 homolog (EAT- 2) EWS-E1A-F chimeric 1 U35622 protein excision repair cross- 1 M28650 + + + + + complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1) excision repair cross- 1 X69978 + + + + complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome)) (ERCC5) exostoses (multiple)-like 3 1 AF001690 + + + + (EXTL3) F11 1 X77744 + F1-ATPase beta subunit 2 X03559 (F-1 beta) Fanconi anaemia group A 2 Z83095 Fanconi anemia, 1 X99226 + + + + complementation group A (FANCA) far upstream element 2 U05040 + + + (FUSE) binding protein 1 (FUBP1) farnesyl diphosphate 1 J05262 + + + + + synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) (FDPS) farnesyl-diphosphate 2 X69141 + + + + + + farnesyltransferase 1 (FDFT1) farnesyltransferase, CAAX 2 L00635 + + box, beta (FNTB) Fas ligand (gene and 1 AF044583 promoter region) Fas-ligand associated 1 U70667 factor 1 fatty-acid-Coenzyme A 4 D10040 + + + + + + ligase, long-chain 1 (FACL1) Fc fragment of IgA, 1 X54150 receptor for (FCAR) Fc fragment of IgE, high 1 M33195 + + + + + affinity I, receptor for; gamma polypeptide (FCER1G) Fc fragment of IgE, low 2 X04772 + + affinity II, receptor for (CD23A) (FCER2) Fc fragment of IgG, low 6 M31932 + + + + + + affinity IIa, receptor for (CD32) Fc fragment of IgG, low 1 X62572 + + + + + + affinity IIa, receptor for (CD32) (FCGR2A) Fc fragment of IgG, low 34 X07934 + + + + + affinity IIIa, receptor for (CD16) (FCGR3A) Fc fragment of IgG, 3 U12255 + + + + + high in many libraries receptor, transporter, alpha (FCGRT) fc-fgr 1 Z13983 Fc-gamma-receptorIIIB 2 M90746 (FCGR3B) feline sarcoma (Snyder- 3 X06292 Theilen) viral (v- fes)/Fujinami avian sarcoma (PRCII) viral (v- fps) oncogene homolog(FES) c-fes/fps) female sterile homeotic- 2 X96670 + + + + + related gene 1 (mouse homolog) (FSRG1) ferritin L-chain 9 Y09188 ferritin, heavy polypeptide 1 4 M11146 + + + + + + (FTH1) fertilin alpha pseudogene 1 Y09232 fetal Alzheimer antigen 2 U05237 + (FALZ) fetal Ig heavy chain 1 M34024 variable region fibrillarin (FBL) 1 X56597 + + + + + + fibrinogen-like protein 2 3 Z36531 + (T49) fibroblast growth factor 1 M35718 + + + + + + receptor 2 (bacteria- expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome) syndrome, Pfeiffer syndrome, Jackson-Weiss) (FGFR2) ficolin (collagen/fibrinogen 19 D83920 + + domain-containing) 1 (FCN1) filamin A, alpha (actin- 2 X53416 binding protein-280) (FLNA) filamin B, beta (actin- 1 AF043045 + + + binding protein-278) (FLNB) Finkel-Biskis-Reilly murine 2 X65923 + + + + + + Highly represented in sarcoma virus (FBR-MuSV) intraepithelial ubiquitously expressed (fox neoplasia and derived); ribosomal protein invasive prostate S30 (FAU) tumor FK-506 binding protein 1 M80199 + + + + + FK506-binding protein 1A 2 M34539 (12 kD) (FKBP1A) FK506-binding protein 1B 1 M92423 + + + (12.6 kD) (FKBP1B) FK506-binding protein 5 4 U71321 + + + + (FKBP5) Flightless I (I Drosophila) 3 U80184 + homolog (FLII) Flightless I (I Drosophila) 1 U80184 homolog (FLII) (low match) FLN29 (FLN29) 2 AB007447 + + + flotillin 2 (FLOT2) 5 M60922 + + + + + + folate receptor 2 (fetal) 1 AF000380 + + + + (FOLR2) forkhead (Drosophila) 1 AF032886 + + + + homolog (rhabdomyosarcoma) like 1 (FKHRL1) Formyl peptide receptor 1 9 M60627 + + + + + (FPR1) formyl peptide receptor-like 1 M84562 Found only in 1 (FPRL1) libraries from placenta formyl peptide receptor-like 1 M84562 1 (FPRL1) (low score) fragile X mental retardation 1 L29074 + + + + 1 (FMR1) fragile X mental 1 U25165 + + + + retardation, autosomal homolog 1 (FXR1) Friend leukemia virus 3 M93255 + + integration 1 (FLI1) fructose-bisphosphatase 1 1 D26054 + + (FBP1) FSHD-associated repeat 1 U85056 DNA, proximal region fucose-1-phosphate 1 AF017445 + + + guanylyltransferase (FPGT) full length insert cDNA 1 AF086122 clone ZA78A09 full length insert cDNA 1 AF075061 YP07G10 fumarate hydratase (FH) 1 U59309 + + + + FUS (low match) 1 X99006 FYN-binding protein (FYB- 16 U93049 + + 120/130) (FYB) G alpha interacting protein 1 X91809 (GAIP) (low score) G protein beta subunit-like 2 D28398 protein 12.3 G protein-coupled receptor 1 X81892 + 64 (HE6) (non-exact 59%) G protein-coupled receptor 2 L16862 + + + + kinase 6 (GPRK6) G1 to S phase transition 1 2 X17644 + + + + + (GSPT1) GA-binding protein 1 D13316 + + + + + transcription factor, beta subunit 2 (47 kD) (GABPB2) galactose-1-phosphate 2 M60091 uridylyltransferase (GALT) galactosidase, beta 1 3 M27508 + + + (GLB1) galactosyltransferase 1 M13701 (=X13223 N- acetylglucosamide-(beta 1- 4)-galactosyltransferase) galectin-9 isoform 1 AB006782 + + + gamma2-adaptin (G2AD) 1 AF068706 + + + + gamma-actin 2 M37130 gamma-aminobutyric acid 2 AJ012187 + + + (GABA) B receptor 1 (GABBR1) GATA-binding protein 2 1 M68891 + + (GATA2) GATA-binding protein 3 1 M69106 + + + (GATA3) GCN5 (general control of 3 D64007 + + + + + amino-acid synthesis, yeast, homolog)-like 1 (GCN5L1) GDP dissociation inhibitor 1 D45021 + + + + + high in adult brain 1 (GDI1) GDP dissociation inhibitor 4 Y13286 2 (GCI2) GDS-related protein 4 U68142 + + + + + (HKE1.5) gelsolin (amyloidosis, 3 X04412 + + + + + Finnish type) (GSN) general transcription factor 4 Y14946 + + + + + + II, I (GTF2I) general transcription factor 1 AF038968 + + + + + + high in fetal brain II, i, pseudogene 1 (GTF2IP1) general transcription factor 4 X64037 + + + + + IIF, polypeptide 1 (74 kD subunit) (GTF2F1) general transcription factor 2 Z30093 B, T IIH, polypeptide 3 (34 kD subunit) (GTF2H3) general transcription factor 3 Y07595 + + + IIH, polypeptide 4 (52 kD subunit) (GTF2H4) general transcription factor 1 U14134 + + + + IIIA (GTF3A) general transcription factor 1 U02619 + + IIIC, polypeptide 1 (alpha subunit, 220 kD) (GTF3C1) general transcription factor 3 D13636 + + + + + + IIIC, polypeptide 2 (beta subunit, 110 kD) (GTF3C2) germline immunoglobulin 1 L06612 heavy chain (IGHV@) germline immunoglobulin 1 X92236 heavy chain, variabl region germline immunoglobulin 1 X92343 heavy chain, variable region, (21-2) GLE1 (yeast homolog)-like, 1 AF058922 + + RNA export mediator (GLE1L) glia maturation factor, beta 1 AB001106 + + + + (GMFB) glioma-associated 1 X07384 oncogene homolog (zinc finger protein) (GLI) glioma-associated 1 X07384 oncogene homolog (zinc finger protein) (GLI) (low score) globin, alpha 2 1 V00516 glucocorticoid receptor 1 M32284 (=M69104) glucocorticoid receptor 2 U80947 + + + + + (GRL) glucos phosphate 1 L09105 isomerase (CONTAINS LARGE REPEAT) glucosamine (N-acetyl)-6- 1 Z12173 + sulfatase (Sanfilippo disease IIID) (GNS) glucosamine (N-acetyl)-6- 1 Z12173 sulfatase (Sanfilippo disease IIID) (GNS) (non- exact 56%) glucose transporter-like 1 M20681 + + + + + protein-III (GLUT3) glucose transporter-like 1 M20681 protein-III (GLUT3) (low match) glucosidase, alpha; acid 1 Y00839 + + + + (Pompe disease, glycogen storage disease type II) (GAA) glucosidase, beta; acid 1 K02920 + + + + + (includes glucosylceramidase) (GBA) glutamate dehydrogenase 1 M20867 + + + + + 1 (GLUD1) glutamate-ammonia ligase 12 X59834 + + + + + (glutamine synthase) (GLUL) glutamate-ammonia ligase 1 Y00387 (glutamine synthase) (GLUL) (low score) glutamate-cysteine ligase 1 M90656 + (gamma-glutamylcysteine synthetase), catalytic (72.8 kD) (GLCLC) glutamine cyclotransferase 1 X71125 + + glutamine-fructose-6- 1 M90516 + + phosphate transaminase 1 (GFPT1) glutaminyl-tRNA 1 X72396 synthetase glutaminyl-tRNA 6 X76013 + + + + + synthetase (QARS) glutamyl-prolyl-tRNA 1 X54326 synthetase (EPRS) glutathione peroxidase 1 2 M21304 + + + + + + (GPX1) glutathione peroxidase 4 1 X71973 + + + + + (phospholipid hydroperoxidase) (GPX4) glutathione S-transferase pi 1 U30897 + + + + + (GSTP1) glutathione S-transferase 1 AF070657 subunit 13 homolog glyceraldehyde-3- 12 J02642 + phosphate dehydrogenase (GAPD) glycogenin (GYG) 1 U31525 + + + + glycophorin C (Gerbich 1 X12496 + + + + blood group) (GYPC) glycoprotein M6B (GPM6B) 1 U45955 + + glycyl-tRNA synthetase 1 U09587 + + + + (GARS) glyoxalase I (lactoyl 1 L07837 + + + + + glutathione lyase) (GLYI) golgi autoantigen, golgin 1 U51587 + + subfamily a, 1 (GOLGA1) golgi autoantigen, golgin 1 L06147 subfamily a, 2 (GOLGA2) (non-exact, 70%) golgi autoantigen, golgin 1 U31906 subfamily a, 4 (GOLGA4) golgi autoantigen, golgin 1 X75304 + + + + subfamily b, macrogolgin (with transmembrane signal), 1 (GOLGB1) gp25L2 protein 4 X90872 grancalcin 8 M81637 + + + granulin (GRN) 16 X62320 + + + + + granulin (GRN) (low match) 1 X62320 Granulysin (NKG5) 5 M85276 + + granzyme A (granzyme 1, 1 M18737 + + + + + cytotoxic T-lymphocyte- associated serine esterase 3) (GZMA) GRB2-related adaptor 1 U52518 T only protein (GRAP) Grb2-related adaptor 1 AF090456 T + protein 2 (GRAP2) GRO1 oncogene 1 X54489 + + (melanoma growth stimulating activity, alpha) (GRO1) growth arrest and DNA- 1 S40706 damage-inducible gene (GADD153) growth arrest-specific 7 4 AB007854 + + (GAS7) growth factor receptor- 1 X62852 B + + + bound protein 2 (GRB2) GS1 (protein of unknown 1 M86934 + + + function) GS3955 4 D87119 + + + + GTP binding protein 1 1 U87964 + + + (GTPBP1) GTP binding protein similar 1 U87791 + + + + to S. cerevisiae HBS1 (HBS1) GTPase activating protein- 1 AB011110 + + + + high fetal brain like (GAPL) GTP-binding protein (low 1 Z49068 match) GTP-binding protein G(K), 1 P08754 alpha subunit (=G(I) ALPHA-3)(=GTP-binding regulatory protein Gi alpha- 3 chain) Gu protein (GURDB) 2 U41387 + + + + guanine nucleotide binding 1 protein guanine nucleotide binding 4 J03004 + + + + + protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2) guanine nucleotide binding 7 M20597 + + + + + protein (G protein), alpha inhibiting activity polypeptide 3 (GNAI3) guanine nucleotide binding 2 X04409 B, T + + + protein (G protein), alpha stimulating activity polypeptide 1 (GNAS1) guanine nucleotide binding 1 Z18859 protein (G protein), alpha transducing activity polypeptide 2 (GNAT2) guanine nucleotide binding 2 AF017656 + + + + protein (G protein), beta 5 (GNB5) guanine nucleotide binding 5 M36430 + + + + + + protein (G protein), beta polypeptide 1 (GNB1) guanine nucleotide binding 2 AF011496 + + + protein (G protein), q polypeptide (GNAQ) guanine nucleotide binding 1 L25665 + + + + + protein-like 1 (GNL1) guanine nucleotide 1 L13857 + + + + exchange factor guanine nucleotide 1 X15610 + + + + + regulatory factor (LFP40) guanine nucleotide 1 U72206 + + + + + regulatory factor (LFP40) GUANINE NUCLEOTIDE- 1 P25388 BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN 12.3 (P205) (RECEPTOR OF ACTIVATED PROTEIN KINASE C 1) (RACK1) GUANINE- 1 U10860 + MONOPHOSPHATE SYNTHETASE (GMPS) guanosine monophosphate 1 M24470 reductase (GMPR) (non- exact, 72%) guanosine-diphosphatase 1 AF016032 like protein guanylate binding protein 2 M55542 + + + + + 1, interferon-inducible, 67 kD (GBP1) guanylate binding protein 6 M55543 + + + + + 2, interferon-inducible (GBP2) H2A histone family, 1 Z83742 member C (H2AFC) H2A histone family, 2 AF041483 + + + + + member Y (H2AY) H2B histone family, 2 Z80783 + + + + + + high in adrenal gland member L (H2BFL) tumor h2-calponin 1 D86059 H-2K binding factor-2 1 L08904 + + + + H3 histone family, member 1 Z83735 K (H3FK) H3 histone, family 3A 7 M11353 + + + + + high in ovary (H3F3A) H3 histone, family 3B 15 Z48950 + + + + + high in endothelial (H3.3B) (H3F3B) cells hbc647 1 U68494 + + + + heat shock 27 kD protein 1 1 U12404 + + + + (HSPB1) heat shock 40 kD protein 1 4 D85429 + + + + + + high in testis (HSPF1) heat shock 60 kD protein 1 3 M22382 + + + + + + (chaperonin) (HSPD1) heat shock 70 kD protein 1 7 M59828 + + + + + + high in activated T (HSPA1A) cells heat shock 70 kD protein 5 13 X87949 + + + (glucose-regulated protein, 78 kD) (HSPA5) heat shock 70 kD protein 6 4 X51757 + + + (HSP70B′) (HSPA6) heat shock 70 kD protein 2 L15189 + + + + + 9B (mortalin-2) (HSPA9B) HEAT SHOCK COGNATE 1 P11142 71 KD PROTEIN heat shock factor binding 2 AF068754 protein 1 (HSBP1) heat shock protein 90 13 M27024 + + + + + + high in many libraries heat shock protein, DNAJ- 1 D13388 + + + + like 2 (HSJ2) Hect (homologous to the 1 U50078 + + + E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 (HERC1) hect domain and RLD 2 1 AB002391 + + + + + (HERC2) helicase-like protein (HLP) 1 X98378 + + + + helix-loop-helix protein 1 M65214 + HE47 (E2A) hematopoietic cell-specific 18 X16663 + + + + Lyn substrate 1 (HCLS1) heme oxygenase 1 X06985 + + + + (decycling) 1 (HMOX1) HEMOGLOBIN ALPHA 1 P19015 CHAIN hemoglobin beta (beta 5 AF117710 globin) hemoglobin, alpha 1 301 V00491 + + + (HBA1) hemoglobin, alpha 1 1 V00491 (HBA1) (low match) hemoglobin, alpha 1 (low 1 V00493 match) hemoglobin, alpha 1 (non- 1 J00153 exact, 76%) hemoglobin, alpha 1 (non- 1 V00493 exact, 82%) hemoglobin, beta (HBB) 129 V00497 + + + + + + high in many libraries hemoglobin, beta (HBB) 1 V00497 (low match) hemoglobin, beta (HBB) 1 L48220 (low match) hemokine (C—X—C motif), 1 D10924 + + + + + receptor 4 (fusin) (CXCR4) hemopoietic cell kinase 5 M16591 + + (HCK) hepatitis C-associated 2 D28908 microtubular aggregate protein p44 hepatoma-derived growth 1 D16431 + + + + + factor Hermansky-Pudlak 2 U65676 syndrome (HPS) HERV-E integrase (non- 1 AF026246 exact 76% aa) heterogeneous nuclear 2 S63912 + + + + protein similar to rat helix destabilizing protein (FBRNP) heterogeneous nuclear 4 M16342 ribonucleoprotein (C1/C2) (HNRPC) heterogeneous nuclear 1 M65028 + + + + + + ribonucleoprotein A/B (HNRPAB) heterogeneous nuclear 20 X12671 + + + + + + High in alveolar ribonucleoprotein A1 rhabdomyosarcoma (HNRPA1) heterogeneous nuclear 3 M29064 + + + + + + High in activated T ribonucleoprotein A2/B1 cell, fetal brain (HNRPA2B1) heterogeneous nuclear 2 D55673 + + + + + + ribonucleoprotein D (hnRNP D) heterogeneous nuclear 5 D89092 + + + + + + ribonucleoprotein D-like (HNRPDL) heterogeneous nuclear 1 L28010 + + + + + ribonucleoprotein F (HNRPF) heterogeneous nuclear 1 L28010 ribonucleoprotein F (HNRPF) (83%) heterogeneous nuclear 2 Z23064 + + + + ribonucleoprotein G (HNRPG) heterogeneous nuclear 3 P55795 ribonucleoprotein H (HNRPH) (FTP-3) heterogeneous nuclear 1 P31943 ribonucleoprotein H (HNRPH) (low match) heterogeneous nuclear 2 L22009 + + + + + ribonucleoprotein H1 (H) (HNRPH1) heterogeneous nuclear 21 S74678 + + + + + + ribonucleoprotein K (HNRPK) heterogeneous nuclear 1 AF000364 + + + + + ribonucleoprotein R (HNRPR) heterogeneous nuclear 3 X65488 + + + + + + ribonucleoprotein U (scaffold attachment factor A) (HNRPU) hexokinase 1 (HK1) 2 X66957 + + + + hexokinase 2 (HK2) 3 Z46376 + + + + + hexokinase 3 (HK3) 2 U51333 hexosaminidase A (alpha 1 S62047 polypeptide) (HEXA HGMP07I gene for 2 U76377 olfactory receptor High density lipoprotein 2 M64098 + + + + + + binding protein (HDLBP) high-mobility group 5 X12597 + + + + + + (nonhistone chromosomal) protein 1 (HMG1) high-mobility group 1 D63874 (nonhistone chromosomal) protein 1 (HMG1) (non- exact 60%) High-mobility group 2 M12623 + + + + + (nonhistone chromosomal) protein 17 (HMG17) high-mobility group 2 M83665 + + + + + + (nonhistone chromosomal) protein 2 (HMG2) high-mobility group 2 L17131 + + + + + (nonhistone chromosomal) protein isoforms I and Y high-risk humanpapilloma 1 AF090990.1 viruses E6 oncoproteins targeted protein E6TP1 beta (=AB007900 KIAA0440) histidine ammonia-lyase 1 D16626 +, (HAL) only histidyl-tRNA synthetase 2 Z11518 + + + + + + (HARS) histocompatibility antigen 1 U31372 (HLA-Cw3), class I histone deacetylase 1 4 U50079 + + + + + (HDAC) histone deacetylase 1 2 D50405 + + + + + (HDAC1) histone deacetylase 5 (NY- 1 AF039691 + + CO-9) HK2 gene for hexokinase II 1 Z46362 HL9 monocyte inhibitory 2 U91928 + receptor precursor HLA class I heavy chain 1 (HLA-Cw*1701) HLA class I locus C heavy 1 X58536 chain HLA class II SB 4-beta 1 X03022 chain HLA class III region 1 U89335 + + + + + containing NOTCH4 gene HLA-A 1 Z72423 HLA-A 2 AJ006020 HLA-A*7402 1 AJ223060 HLA-A11 1 U02934 HLA-B 2 X75953 HLA-B 1 X83401 HLA-B 1 X78426 HLA-B associated 1 Z37166 + + + + + + transcript-1 (D6S81E) HLA-B associated 2 M33509 + + + + transcript-2 (D6S51E) HLA-B*1529 4 D44501 HLA-Bw72 antigen 119 L09736 + + + + + + high in many libraries HLA-C gene (HLA- 1 D83957 Cw*0701 allele) HLA-Cw*0701 9 Z46810 HLA-Cw*0801 1 D64151 HLA-Cw*1203 1 D64146 HLA-DC classII 2 X00370 histocompatibility antigens alpha-chain (=K01160) HLA-DR alpha-chain 17 M60333 + + + + + + high in spleen HLA-F (leukocyte antigen 3 X17093 + + + F) HMG box containing 3 AF019214 protein 1 hMLH1 (=U83845) 1 AB017806.1 Hmob33 3 Y14155 HMT1 (hnRNP 2 U80213 + + + + + methyltransferase, S. cerevisiae)- like 1 (HRMT1L1) hnRNP C1/C2 2 D28382 homeobox (=X58250 1 M60721 Mouse homeo box protein, put. transcription factor involved in embryogenesis and hematopoiesis) homeobox protein (HLX1) 1 U14326 (=M60721) homeodomain-interacting 1 AF004849 + + + + protein kinase 3 (HIPK3) homolog of Drosophila past 2 AF001434 + + + + + (PAST) homolog of yeast (S. cerevisiae) 3 D50916 + + + + ufd2 (UFD2) HPV16 E1 protein binding 1 U96131 + + + protein HRIHFB2157 1 AB015344 + + + HRX-like protein 1 Y08836 (=AF010403 ALR) hsc70 gene for 71 kd heat 3 Y00371 shock cognate protein HSPC012 1 AF077036.1 HSPC021 1 AF077207.1 HsPex13p 1 U71374 htra2-beta-2 1 U87836 + + + + + HU-K4 1 U60644 hunc18b2 1 U63533 + + + + HUNKI 1 Y12059 + + + + + huntingtin-interacting 1 AF049528 protein HYPA/FBP11 (HYPA) hVps41p (HVPS41) 1 U87309 hydroxyacyl-Coenzyme A 1 U04627 + + + dehydrogenase/3-ketoacyl- Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (HADHA) hydroxyacyl-Coenzyme A 1 D16481 + + + + + dehydrogenase/3-ketoacyl- Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit (HADHB) hydroxysteroid (17-beta) 1 U34879 + + dehydrogenase 1 (HSD17B1) hypothetical protein 1 hypothetical protein 1 (AL008729) (dJ257A7.2) hypothetical protein 1 U96629 (CIT987SK_2A8_1 chromosome 8) hypothetical protein (clone 1 AF055004 24640) hypothetical protein (clone 1 Z70222 ICRFp507G2490). hypothetical protein 1 AL022238 (dJ1042K10.4) (non-exact 76%) hypothetical protein 2 AL031432 (dJ465N24.1 similar to predicted yeast and worm proteins) hypothetical protein 2 AL008730 (dJ487J7.1.1) hypothetical protein 2 AL023653 (dJ753P9.2) hypothetical protein 1 AL050131.1 (DKFZp586I111) hypothetical protein 1 AL008729 (J257A7.2) hypothetical protein 1 AB007900 (KIAA0440) (=AF026504 R. norvegicus SPA-1 like protein) hypothetical protein (L1H 3′ 1 region) hypothetical protein (S164) 1 P49756 hypothetical protein (similar 1 AF109907 to thrombospondin) (non- exact 56%) hypothetical protein 3 1 hypothetical protein B 1 U47926 (HSU47926) (non-exact, 56%) hypothetical protein from 3 U50532 + + + + + BCRA2 region (CG005) hypoxia-inducible factor 1, 1 AF050115 alpha subunit (basic helix- loop-helix transcription factor) (HIF1A) Ia-associated invariant 1 M13555 gamma-chain (clones lambda-y (1,2,3)) iduronate 2-sulfatase 2 M58342 + + + + + (Hunter syndrome) (IDS) Ig heavy chain V region 1 L20779 (=D11016) Ig heavy chain variable 2 M34024 region Ig heavy chain variable 1 Z75378 region (VH4DJ) (clone T14.4) Ig heavy chain variable 1 Z75392 region (VH4DJ) (clone T22.18) Ig J chain 1 M12378 Ig kappa 1 S49007 IG kappa light chain 1 X63398 variable region A20 Ig kappa light chain, V- and 1 D90158 J-region (=X59315) Ig lambda light chain 1 Z85052 variable region (26- 34ITIIIF120) Ig mu-chain VDJ4-region 1 M16949 Ig rearranged anti-myelin 1 M29469 kappa-chain (V-J4-region, hybridoma AE6-5) Ig rearranged H-chain 2 M97920 mRNA V-region Ig rearranged light-chain V 1 M74020 region (=D90158) IGF-II mRNA-binding 1 U97188 + + + protein 3 (KOC1) (non- exact, 75%) IgG Fc binding protein 1 D84239 + + + + (FC(GAMMA)BP) IgG heavy chain variable 1 M83136 region (vH26) IgM heavy chain (C mu, 1 X14939 membrane exons) IkB kinase-beta (IKK-beta) 1 AF029684 IL-1 receptor type II 1 U14177 IL2-inducible T-cell kinase 2 S65186 (ITK) immediate early protein 1 M62831 + + + + (ETR101) immunogloblin light chain 1 D87018 (lambda) Immunoglobulin (CD79A) 1 Y08915 B, T + + + binding protein 1 (IGBP1) immunoglobulin C (mu) 2 X57331 and C (delta) heavy chain (=K02878) immunoglobulin G Fc 1 Z46223 receptor IIIB immunoglobulin gamma 3 3 Y14737 + + + high in many libraries (Gm marker) (IGHG3) immunoglobulin gamma 1 Z66542 heavy chain variable region (=X61011) immunoglobulin heavy 1 X62109 chain (VI-3B) immunoglobulin heavy 1 X86356 chain J region immunoglobulin heavy 2 X86355 chain J region, B1 haplotype immunoglobulin heavy 1 AF062126 chain variable region (IGH) (clone 21u-48) immunoglobulin heavy 1 AF062212 chain variable region (IGH) (clone 23u-1) immunoglobulin heavy 2 M99641 chain variable region V1-18 (IGHV@) (=X60503) immunoglobulin heavy 2 M99672 chain variable region V3-43 (IGHV@) immunoglobulin heavy 3 M99649 chain variable region V3-7 (IGHV@) immunoglobulin IgH heavy 1 U07986 chain Fd fragment immunoglobulin kappa light 1 X58081 chain immunoglobulin kappa light 1 X12686 chain V-segment A27 immunoglobulin light chain 1 D86990 immunoglobulin light chain 1 D86996 (low match) immunoglobulin light chain 1 L29157 variable region (lambda IIIb subgroup) from IgM rheumatoid factor immunoglobulin M heavy 1 S50735 chain V region = anti-lipid A antibody immunoglobulin mu (IGHM) 9 X57086 + + + + immunoglobulin mu binding 1 L24544 T + + protein 2 (IGHMBP2) immunoglobulin 1 Z33642 superfamily, member 2 (IGSF2) Immunoglobulin VH mRNA 1 X61013 (487 bp) (=M99652 immunoglobulin heavy chain variable region V3-11 (IGHV@)) imogen 38 (IMOGEN38) 1 Z68747 + + + + IMP (inosine 1 J05272 + + + + monophosphate) dehydrogenase 1 (IMPDH1) IMP (inosine 2 L39210 + + + + + monophosphate) dehydrogenase 2 (IMPDH2) inc finger protein 151 (pHZ- 1 Y09723 + + + + + 67) (ZNF151) inc finger protein, C2H2, 1 AF011573 + + rapidly turned over (ZNF20) inducible poly(A)-binding 1 U33818 + + + + + protein (IPABP) inducible poly(A)-binding 1 U33818 protein (IPABP) (low match) inducible protein 2 L47738 + + + + + (Hs.80313) inhibitor of DNA binding 2, 4 M97796 + + + + + + dominant negative helix- loop-helix protein (ID2) inhibitor of kappa light 2 AF044195 polypeptide gene enhancer in B-cells, kinase complex- associated protein (IKBKAP) inositol 1,3,4-trisphosphate 1 U51336 + + + + + + 5/6-kinase inositol 1,4,5 trisphosphate 1 U23850 + + + receptor type 1 (ITPR1) inositol 1,4,5-trisphosphate 2 X57206 B + + + 3-kinase B (ITPKB) inositol monophosphatase 1 S38980 inositol polyphosphate-5- 2 U84400 + + + + + phosphatase, 145 kD (INPP5D) Ins(1,3,4,5)P4-binding 1 X89399 + + protein insulin-like growth factor 2 5 Y00285 + + + + + receptor (IGF2R) integral membrane protein 1 L38961 + + + 1 (ITM1) integral membrane protein 1 AF038953 T + + + 2C (ITM2C) integral membrane protein 3 U61734 + + + + + + Tmp21-I (p23) integrin beta 4 binding 2 AF047433 + + protein (ITGB4BP) integrin, alpha 2b (platelet 3 M34480 + + glycoprotein IIb of IIb/IIIa complex, antigen CD41B) (ITGA2B) integrin, alpha 5 4 X06256 + + + + + (fibronectin receptor, alpha polypeptide) (ITGA5) integrin, alpha L (antigen 6 Y00796 CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL) integrin, alpha M 1 M18044 (complement componentreceptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide) (ITGAM) integrin, alpha X (antigen 1 M81695 + + + CD11C (p150), alpha polypeptide) (ITGAX) integrin, beta 1 (fibronectin 2 X07979 receptor, beta polypeptide, antigen CD29 includes MDF2 MSK12) (ITGB1) integrin, beta 2 (antigen 32 M15395 + + + + CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) (ITGB2) integrin, beta 7 (ITGB7) 1 M68892 + Integrin-linked kinase (ILK) 1 U40282 + + + + + intercellular adhesion 1 J03132 + + + + molecule 1 (CD54), human rhinovirus receptor (ICAM1) intercellular adhesion 1 X15606 + + + + + molecule 2 (ICAM2) intercellular adhesion 6 X69819 + + molecule 3 (ICAM3) intercellular adhesion 1 L27670 + molecule 4, Landsteiner- Wiener blood group (ICAM4) Interferon consensus 1 M91196 W, T sequence binding protein 1 lymphoma (ICSBP1) Interferon consensus 1 M91196 sequence binding protein 1 (ICSBP1) (low match) interferon regulatory factor 4 X15949 + + + + 2 (IRF2) interferon regulatory 4 L05072 + + + + + factor1 (IRF1) interferon regulatory 1 U51127 + + + factor5 (IRF5) interferon, gamma- 2 M63838 + + + + + inducible protein 16 (IFI16) interferon, gamma- 9 J03909 + + + + inducible protein 30 (IFI30) INTERFERON-INDUCED 1 P32455 GUANYLATE-BINDING PROTEIN 1 (GUANINE NUCLEOTIDE-BINDING PROTEIN 1) (non-exact 62%) interferon-induced protein 3 X84958 + + + + 17 (IFI17) interferon-induced protein 5 M14660 54 (IFI54) interferon-inducible (1-8D) 5 X57351 T + + + interferon-inducible (1-8U) 1 X57352 + + + interferon-related 5 Y10313 + + + developmental regulator 1 (IFRD1) interferon-stimulated 2 M87503 + + + transcription factor 3, gamma (48 kD) (ISGF3G) interleukin 1 receptor, type 1 U64094 + II (IL1R2) Interleukin 10 receptor, 1 U08988 T activated + + beta (I.10RB) interleukin 12 receptor, 2 U03187 + only found in T cell beta 1 (IL12RB1) interleukin 13 receptor, 2 Y09328 + + + + + alpha 1 (IL13RA1) interleukin 16 (lymphocyte 6 U82972 + chemoattractant factor) (IL16) interleukin 18 receptor 1 1 U43672 (IL18R1) interleukin 2 receptor, beta 9 M26062 (IL2RB) interleukin 2 receptor, 6 D11086 + + + gamma (severe combined immunodeficiency) (IL2RG) interleukin 4 receptor 3 X52425 + + + + (IL4R) interleukin 6 receptor 5 X12830 + + (IL6R) interleukin 6 signal 1 M57230 transducer (gp130, oncostatin M receptor) (IL6ST) interleukin 7 receptor 14 M29696 + + (IL7R) interleukin 7 receptor 1 AF043123 (IL7R) (low match) interleukin 8 (IL8) 8 Y00787 + + + High in activated T cells, bone and pancreatic islets interleukin 8 receptor alpha 11 L19591 (IL8RA) interleukin 8 receptor, beta 14 M94582 (IL8RB) interleukin enhancer 3 U10323 + + + + + + high in uterus binding factor 2, 45 kD (ILF2) interleukin enhancer 2 U10324 binding factor 3, 90 kD (ILF3) interleukin-1 receptor- 2 L76191 + + + + associated kinase 1 (IRAK1) interleukin-1 receptor- 1 U52112 associated kinase 1 (low match) interleukin-10 receptor, 5 U00672 + + + + alpha (IL10RA) interleukin-11 receptor, 7 Z38102 + + alpha (IL11RA) INTERLEUKIN-14 1 P40222 PRECURSOR (IL-14) (HIGH MOLECULAR WEIGHT B-CELL GROWTH FACTOR) (HMW-BCGF) (non-exact 46%) intestinal carboxylesterase; 1 U60553 + + liver carboxylesterase-2 (ICE) inversin protein (non-exact 1 AF084367 52%) IQ motif containing 6 L33075 GTPase activating protein 1 (IQGAP1) IQ motif containing 1 U51903 + + GTPase activating protein 2 (IQGAP2) isocitrate dehydrogenase 1 1 AF020038 + + + + + + (NADP+), soluble (IDH1) isocitrate dehydrogenase 2 2 X69433 + + + + + + (NADP+), mitochondrial (IDH2) isocitrate dehydrogenase 3 2 U07681 + (NAD+) alpha (IDH3A) isocitrate dehydrogenase 3 1 Z68907 + + + + + (NAD+) gamma (IDH3G) isolate Aus3 cytochrome b 1 AF042516 (CYTB) isolate TzCCR5-179 CCR5 1 AF011524 receptor (CCR5) isopentenyl-diphosphate 5 X17025 + + + + + delta isomerase (IDI1) Janus kinase 1 (a protein 4 M64174 + + + + + tyrosine kinase) (JAK1) Janus kinase 2 (a protein 1 AF005216 tyrosine kinase) (JAK2) Jk-recombination signal 2 L07876 binding protein (RBPJK) JM1 protein 1 AJ005890 + + jumonji (mouse) homolog 1 U57592 + + + + (JMJ) jun D proto-oncogene 1 X51346 + + + + + (JUND) jun dimerization protein 1 AF111167 only found in germ junction plakoglobin (JUP) 1 M23410 + + + + kangai 1 (suppression of 1 U20770 + + + + + + tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) (KAI1) karyopherin (importin) beta 2 L39793 + + + + + + 1 (KPNB1) karyopherin (importin) beta 1 U72395 + + + + 2 (KPNB2) karyopherin alpha 1 1 S75295 + + + + (importin alpha 5) (KPNA1) karyopherin alpha 2 (RAG 1 U09559 cohort 1, importin alpha 1) (DPNA2) karyopherin alpha 3 1 D89618 + + (importin alpha 4) (KPNA3) karyopherin alpha 4 1 M17887 + + (KPNA4) Katanin (80 kDa) (KAT) 1 AF052432 + + + + KE03 protein 2 AF064604 Kelch-like ECH-associated 1 D50922 protein 1 (KIAA0132) (66% aa) Keratin 8 (KRT8) 1 X74929 + + + + + ketohexokinase 1 X78678 + + + (fructokinase) (KHK) KIAA0001 (KIAA0001) 1 Q15391 (72% aa) KIAA0001 (KIAA0001) 1 Q15391 (76% aa) KIAA0001 (KIAA0001) 1 Q15391 (non-exact 72%) KIAA0002 (KIAA0002) 5 D13627 + + + + KIAA0005 (KIAA0005) 4 D13630 + + + + KIAA0010 (KIAA0010) 1 D13635 + + KIAA0016 (KIAA0016) 1 D13641 + + + + + KIAA0017 (KIAA0017) 2 D87686 KIAA0022 (KIAA0022) 2 D14664 + + + KIAA0023 (KIAA0023) 1 D14689 + KIAA0024 (KIAA0024) 1 D14694 + + + + + KIAA0025 (KIAA0025) 1 D14695 + + + + + KIAA0026 (KIAA0026) 2 D14812 + + + + KIAA0027 1 D25217 + KIAA0032 (KIAA0032) 2 D25215 + + + KIAA0040 (KIAA0040) 1 D25539 + + + + + KIAA0050 (KIAA0050) 4 D26069 KIAA0053 (KIAA0053) 17 D29642 + + + KIAA0057 (KIAA0057) 1 D31762 + + + + + + high in fetal lung KIAA0058 (KIAA0058) 11 D31767 + + + + + KIAA0063 (KIAA0063) 3 D31884 + + + + + KIAA0064 (KIAA0064) 1 D31764 + + + + + KIAA0066 1 D31886 + + + + + KIAA0068 1 D38549 + + + + + KIAA0073 3 D38552 + + + + KIAA0081 2 D42039 + + + KIAA0084 2 D42043 + + + + + KIAA0085 26 U30498 + + + + + + KIAA0088 3 D42041 + + + + + + KIAA0090 2 D42044 + + + + + + KIAA0092 (KIAA0092) 1 D42054 + + + + KIAA0094 3 D42084 + + KIAA0095 (KIAA0095) 1 D42085 KIAA0096 1 D43636 + + + + + KIAA0097 (KIAA0097) 1 X92474 T + + + KIAA0099 (KIAA0099) 3 D43951 + + + + + + KIAA0102 (KIAA0102) 2 D14658 + + + + KIAA0105 1 D14661 B + + + KIAA0120 2 P37802 KIAA0120 (non-exact, 1 M83106 65%) KIAA0121 (KIAA0121) 1 D50911 + + + + + KIAA0123 1 D21064 + + + + KIAA0128 1 D50918 + + + + + KIAA0129 (KIAA0129) 1 D50919 + + + + KIAA0130 (KIAA0130) 1 AF055995 + + + KIAA0136 2 D50926 KIAA0137 (KIAA0137) 1 AB004885 + + + + KIAA0140 (KIAA0140) 1 D50930 + + + + KIAA0141 (KIAA0141) 3 D50931 KIAA0144 (KIAA0144) 3 D63478 + + + + + KIAA0144 (KIAA0144) (low 1 D63478 match) KIAA0144 (non-exact 61%) 1 Q14157 KIAA0144 (non-exact 65%) 1 Q14157 KIAA0146 2 D63480 + + + + KIAA0148 (KIAA0148) 1 D63482 + + KIAA0154 2 D63876 + + + + + KIAA0156 1 D63879 + + + + KIAA0160 2 D63881 KIAA0161 (KIAA0161) 1 D79983 + + + KIAA0164 (KIAA0164) 3 D79986 KIAA0167 (KIAA0167) 1 D79989 + KIAA0168 (KIAA0168) 3 D79990 + + + + KIAA0169 3 D79991 KIAA0171 (KIAA0171) 3 D79993 + + + + KIAA0174 (KIAA0174) 7 D79996 + + + + + KIAA0179 2 D80001 + + + + KIAA0181 1 D80003 + + + + KIAA0183 4 D80005 + + + + + + KIAA0184 1 D80006 + + + + + KIAA0191 (72% aa) 1 D83776 KIAA0191 (non-exact 77%) 1 KIAA0193 (KIAA0193) 1 D83777 + + + + + KIAA0200 (KIAA0200) 1 D83785 + + + + KIAA0210 (KIAA0210) 3 D86965 KIAA0217 2 D86971 + + + + + KIAA0219 2 U77700 + + + + KIAA0222 (KIAA0222) 1 D86975 KIAA0223 2 D86976 KIAA0229 1 D86982 + + KIAA0232 (KIAA0232) 1 D86985 + + + + KIAA0233 (KIAA0233) 1 D87071 KIAA0235 2 D87078 + + + + KIAA0239 1 D87076 + + KIAA0239 (non-exact 80%) 1 D87076 KIAA0240 1 D87077 KIAA0242 4 D87684 + + + + + + KIAA0248 2 D87435 + + + + KIAA0249 (KIAA0249) 3 D87436 + + + + + KIAA0253 5 D87442 + + + + + + KIAA0254 (KIAA0254) 1 D87443 + + + KIAA0255(KIAA0255) 4 D87444 + + + + KIAA0262 (KIAA0262) 3 D87451 + + + + + KIAA0263 (KIAA0263) 1 D87452 + + + + + KIAA0264 3 D87453 + + + + KIAA0268 1 D87742 + + + + KIAA0269 1 Q92558 KIAA0275 (KIAA0275) 13 D87465 + + + + KIAA0304 (KIAA0304) 2 AB002302 + + + + + + KIAA0308 2 AB002306 + + + KIAA0310 (KIAA0310) 1 AB002308 + + + + KIAA0314 (=U96635 3 AB002312 M. musculus ubiquitin protein ligase Nedd-4) KIAA0315 (KIAA0315) 4 AB002313 + + + + + KIAA0325 (=L08505 2 AB002323 R. norvegicus cytoplasmic dynein heavy chain (MAP1C)) KIAA0329 (KIAA0329) 1 AB002327 + + + + KIAA0330 1 AB002328 + + + + KIAA0332 1 AB002330 + + + + KIAA0333 2 AB002331 + + + + + KIAA0336 (KIAA0336) 3 AB002334 + + + + + KIAA0336 (KIAA0336) (low 1 AB002334 match) KIAA0342 (KIAA0342) 1 AB002340 + + + KIAA0344 (KIAA0344) 2 AB002342 + + KIAA0354 (KIAA0354) 1 AB002352 + + + + + KIAA0365 (KIAA0365) 3 AB002363 + + + + + + KIAA0370 6 AB002368 + + + + + KIAA0372 (KIAA0372) 1 AB002370 KIAA0373 (KIAA0373) 1 AB002371 + + KIAA0375 (KIAA0375) 1 AB002373 + + KIAA0377 (KIAA0377) 1 AB002375 + + + KIAA0379 1 AB002377 + KIAA0379 (non-exact, 1 AB002377 65%) KIAA0380 (KIAA0380) 1 AB002378 + + + + KIAA0380 (KIAA0380) 1 AB002378 (60% aa) KIAA0382 (KIAA0382) 2 AB002380 + + + + KIAA0383 1 AB002381 KIAA0386 (KIAA0386) 5 AB002384 KIAA0392 1 AB002390 KIAA0397 (KIAA0397) 4 AB007857 + + + + + KIAA0403 3 AB007863 KIAA0404 1 AB007864 + + KIAA0409 1 AB007869 + + KIAA0421 1 AB007881 + + + + KIAA0424 (non-exact 82%) 1 AB007884 KIAA0428 (KIAA0428) 9 Y13829 KIAA0429 (KIAA0429) 2 AB007889 + + + + + KIAA0430 (KIAA0430) 2 AB007890 only in ovary KIAA0432 (KIAA0432) 2 U86753 T + + KIAA0435 (KIAA0435) 1 AB007895 KIAA0438 (KIAA0438) 1 AB007898 + + + + KIAA0447 (KIAA0447) 3 AB007916 + + + + + KIAA0449 1 AB007918 + + KIAA0456 1 AB007925 + + + + KIAA0458 (KIAA0458) 1 AB007927 KIAA0462 1 AB007931 + + + + + KIAA0465 1 AB007934 + + + + + KIAA0476 (KIAA0476) 1 AB007945 + + + KIAA0489 1 AB007958 KIAA0494 (KIAA0494) 1 AB007963 + + + + + KIAA0515 1 AB011087 + + + + + KIAA0521 3 AB011093 + + + KIAA0525 1 AB011097 + + KIAA0530 1 AB011102 + + + KIAA0532 1 AB011104 + + + + + KIAA0537 (KIAA0537) 1 AB011109 KIAA0540 1 AB011112 + + + + + KIAA0543 1 AB011115 + + + KIAA0544 1 AB011116 + + + + KIAA0549 2 AB011121 + + + + KIAA0551 2 AB011123 + + KIAA0554 8 AB011126 + + + + KIAA0561 1 AB011133 + + KIAA0562 (KIAA0562) 1 AB011134 KIAA0563 (KIAA0563) 1 AB011135 KIAA0569 (KIAA0569) 2 AB011141 + + + + KIAA0571 (KIAA0571) 2 AB011143 + + + KIAA0573 1 AB011145 + + + KIAA0576 1 AB011148 KIAA0580 1 AB011152 KIAA0584 1 AB011156 + KIAA0592 3 AB011164 + + + + + KIAA0596 1 AB011168 + + KIAA0598 (KIAA0598) 1 AB011170 + + + KIAA0608 1 AB011180 + + KIAA0614 2 AB014514 + + + + + KIAA0615 (KIAA0615) 1 AB014515 KIAA0621 1 AB014521 + + + KIAA0648 1 AB014548 + + + + KIAA0652 (KIAA0652) 1 AB014552 + + + + + KIAA0668 1 AB014568 KIAA0669 1 AB014569 KIAA0671 (KIAA0671) 1 AB014571 + + + KIAA0675 (KIAA0675) 1 AB014575 + + + KIAA0676 1 AB014576 + + + + KIAA0677 (KIAA0677) 2 AB014577 + + + + + KIAA0678 1 AB014578 + + + + + KIAA0679 6 AB014579 + + + + KIAA0680 (KIAA0680) 1 AB014580 KIAA0692 1 AB014592 + + + + + KIAA0697 1 AB014597 KIAA0699 1 AB014599 + + + + + KIAA0700 1 AB014600 + + + + KIAA0737 (KIAA0737) 3 AF014837 + + + + + KIAA0748 (KIAA0748) 2 AB018291 + KIAA0763 (KIAA0763) 2 AB018306 + + + + + KIAA0769 (KIAA0769) 2 AB018312 + + + + KIAA0782 1 AB018325 + + + high in BPH stroma KIAA0796 1 AB018339 + + + + KIAA0798 (KIAA0798) 1 AB018341 KIAA0823 1 AB020630 KIAA0854 1 AB020661 + + + + + KIAA0856 1 AB020663 + + + + KIAA0860 1 AB020667 + + KIAA0862 1 AF054828 + + + KIAA0871 (non-exact 88%) 1 AB020678 KIAA0873 1 AB020680 + + + + KIAA0892 1 AB020699 + + + + + KIAA0906 1 AB020713 + + + + + KIAA0991 1 AB023208.1 killer cell lectin-like 1 U11276 + + + receptor subfamily B, member 1 (KLRB1) killer cell lectin-like 1 U96846 receptor subfamily C, member 4 (KLRC4) kinectin 1 (kinesin receptor) 1 D13629 (KTN1) kinesin family member 5B 2 X65873 + + + (KIF5B) kinesin-like DNA binding 1 AB017430 + + + + + protein Krueppel-related DNA- 1 M61869 binding protein (TF6) (low match) Kruppel related gene 1 M20675 (clone pHKR1RS) Kruppel-like zinc finger 3 U51869 + + + + + + protein Zf9 Kruppel-like zinc finger 1 U44975 + + + + protein Zf9 (non-exact 76%) kruppel-type zinc finger 1 AB011414.1 protein, ZK1 L apoferritin 3 X03742 lactate dehydrogenase A 3 X02152 + + + + + (LDHA) lactate dehydrogenase A 1 X02152 (LDHA) (non-exact, 81%) lactate dehydrogenase B 6 X13794 + + + + + + high in fetal lung (LDHB) fibrablast lactotransferrin (LTF) 1 U07643 + + + high in bone marrow laminin binding protein (low 1 D28372 score) laminin receptor 1 (67 kD); 20 X15005 + + + + + + high in many libraries Ribosomal protein SA (LAMR1) laminin receptor homolog 1 S35960 {3′ region} laminin, gamma 1 (formerly 2 J03202 + + + + LAMB2) (LAMC1) latent transforming growth 2 M34057 + + + + factor beta binding protein 1 (LTBP1) LAZ3/BCL6 1 Z79581 (=Z79582; D28522/4) LDLC 2 Z34975 + + + + + lecithin-cholesterol 1 M17959 acyltransferase (LCAT) (non-exact, 66%) lectin, galactoside-binding, 1 M87842 + soluble, 2 (galectin 2) (LGALS2) lectin, galactoside-binding, 1 L13210 + + + + + soluble, 3 binding protein (galectin 6 binding protein) (LGALS3BP) leucine rich repeat (in FLII) 5 AJ223075 + + + + + + interacting protein 1 (LRRFIP1) leucocyte immunoglobulin- 2 AF072099 + like receptor-5 (LIR-5) leucocyte immunoglobulin- 7 AF025530 like receptor-6a (LIR-6) leucocyte immunoglobulin- 2 U82275 + only found in CNS like receptor-7 (LIR-7) leukemia virus receptor 1 1 L20859 + + + + + (GLVR1) leukocyte adhesion protein 1 M29484 p150,95 alpha subunit leukocyte antigen, HLA-A2 3 Y13267 leukocyte immunoglobulin- 3 AF025528 + like receptor (MIR-10) leukocyte tyrosine kinase 1 X60702 + found only in blood (LTK) leukocyte-associated Ig- 3 AF013249 + like receptor 1 (LIAR1) leukotriene A4 hydrolase 6 J03459 + + + + + + (LTA4H) leupaxin (LDPL) 2 AF062075 + + + ligase I, DNA, ATP- 1 M36067 B, T + + + + dependent (LIG1) LIM and SH3 protein 1 2 X82456 + + + + + + (LASP1) LIM domain kinase 2 2 AC002073 + + + + + (LIMK2) line-1 protein 1 Line-1 repeat mRNA with 2 1 U93566 + + + + + + open reading frames Line-1 repeat with 2 open 1 M22332 + + + + + + high in gastric tumor reading frames LINE-1 REVERSE 1 P08547 TRANSCRIPTASE HOMOLOG lipase A, lysosomal acid, 4 X76488 + + + + + cholesterol esterase (Wolman disease) (LIPA) lipase, hormone-sensitive 1 L11706 + + + (LIPE) LMP7 1 L11045 Lon protease-like protein 2 X74215 + + + + + (LONP) low density lipoprotein- 2 AF058414 + only in liver related protein 1 (alpha-2- macroglobulin receptor) (LRP1) low density lipoprotein- 1 M63959 + + + + related protein-associated protein 1 (alpha-2- macroglobulin receptor- associated protein 1) (LRPAP1) low density lipoprotein- 1 M63959 related protein-associated protein 1 (alpha-2- macroglobulin receptor- associated protein 1) (LRPAP1) (non-exact, 75%) low-affinity Fc-gamma 1 L08107 receptor IIA LPS-induced TNF-alpha 9 AF010312 + + + + + + factor (PIG7) Lst-1 1 U00921 + + + + + L-type amino acid 1 AF104032 transporter subunit LAT1 lung resistance-related 1 X79882 + + + + + protein (LRP) Lymphocyte antigen 75 1 AF011333 B (LY75) lymphocyte antigen 9 (LY9) 2 L42621 lymphocyte antigen HLA- 2 L42345 B*4402 and HLA-B*5101 lymphocyte cytosolic 42 J02923 protein 1 (L-plastin) (LCP1) lymphocyte cytosolic 4 U20158 T protein 2 (SH2 domain- lymphoma, containing leukocyte T activated protein of 76 kD) (LCP2) lymphocyte glycoprotein 2 X04391 + + T1/Leu-1 lymphocyte-specific protein 16 M33552 + + + + + 1 (LSP1) lymphocyte-specific protein 7 M36881 + + tyrosine kinase (LCK) lymphoid phosphatase 1 AF001847 LyP1 lymphoid-restricted 4 U10485 + + + membrane protein (LRMP) lymphoid-specific SP100 1 U36500 + homolog (LYSP100-A) lymphoma proprotein 2 U33849 + + + + + convertase (LPC) LYSOSOMAL 1 P10619 PROTECTIVE PROTEIN PRECURSOR (CATHEPSIN A) (CARBOXYPEPTIDASE C) lysosomal-associated 1 J04182 + + + + + + membrane protein 1 (LAMP1) Lysosomal-associated 1 J04183 + + + + + membrane protein 2 (LAMP2) lysozyme (renal 39 M19045 + + + + + amyloidosis) (LYZ) lysyl-tRNA synthetase 2 D32053 + + + + + (KARS) M phase phosphoprotein 1 X98494 10 (U3 small nucleolar ribonucleoprotein) (MPP- 10) M1-type and M2-type 2 X56494 pyruvate kinase m6A methyltransferase 7 AF014837 + + + (MT-A70) mab-21 (C. elegans)-like 1 1 U38810 + + + + (MAB21L1) MacMarcks 1 X70326 + + + + + + macrophage-associated 1 Z22968 + + + + antigen (MM130) MADS box transcription 1 U49020 + + + + enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) (MEF2A) MADS box transcription 1 L08895 + + + + enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) (MEF2C) major cytoplasmic tRNA- 1 X17516 Val(IAC) (=M33940) major histocompatibility 1 M95531 complex class I beta chain (HLA-B) major histocompatibility 41 Z93949 + + + + + high in villous complex, class I, A (HLA-A) adenoma major histocompatibility 1 Z72422 complex, class I, A (HLA-A) (low match) major histocompatibility 82 M24097 + + + + + + complex, class I, C (HAL- C) major histocompatibility 77 M20022 + + + + + complex, class I, E (HLA-E) major histocompatibility 2 U15085 + + + + + complex, class II, DM BETA (HLA-DMB) major histocompatibility 10 M57466 + + + + + complex, class II, DP beta 1 (HLA-DPB1) major histocompatibility 9 V00522 + + + + + complex, class II, DR beta 1 (HLA-DRB1) Major histocompatibility 2 M24070 + + + + complex, class II, Y box- binding protein I; DNA- binding protein B (YB1) malate dehydrogenase 1, 1 D55654 + + + + + + NAD (soluble) (mdh1) malate dehydrogenase 1, 3 D55654 + + + + NAD (soluble) (MDH1) malonyl-CoA 2 AF097832 decarboxylase precursor maltase-glucoamylase 1 AF016833 + (mg) manic fringe (Drosophila) 1 U94352 + + + + + homolog (MFNG) mannose phosphate 1 X76057 + + + + isomerase (MPI) mannose phosphate 2 X76057 + + + + isomerase (mpi) mannose-6-phosphate 3 X56253 + + + + receptor (cation dependent) (M6PR) mannose-P-dolichol 1 AF038961 + + + + utilitzation defect 1 (MPDU1) mannosidase, alpha B, 1 U60885 + + + + lysosomal (MANB) mannosyl (alpha-1,3-)- 1 M55621 + + + + + + glycoprotein beta-1,2-N- acetylglucosaminyltransferase (MGAT1) map 4q35 repeat region 1 AF064849 MAP kinase-interacting 2 AB000409 + + + + + serine/threonine kinase 1 (MKNK1) MAP/ERK kinase kinase 3 5 U78876 + (MEKK3) MAP/ERK kinase kinase 5 1 D84476 + + + (MEKK5) MAP/microtubule affinity- 4 M80359 + + + regulating kinase 3 (MARK3) Marenostrin protein 1 Y14441 MASL1 1 AB016816 MAX dimerization protein 3 L06895 + (MAD) MaxiK potassium channel 1 AF035046 beta subunit MBP-2 for MHC binding 1 X65644 + + + + protein 2 Meis (mouse) homolog 3 1 U68385 + + + + (MEIS3) melanoma-associated 1 M12154 antigen p97 (melanotransferrin) membrane cofactor protein 4 X59405 + + + + (CD46, trophoblast- lymphocyte cross-reactive antigen) (MCP) membrane component, 4 D14696 + + + + + chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) (M17S2) membrane metallo- 2 J03779 B + + + + endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) (MME) membrane protein, 2 M64925 + + + + + palmitoylated 1 (55 kD) (MPP1) meningioma expressed 1 U94780 + antigen (MGEA) meningioma-expressed 1 U73682 + + + + antigen 11 (MEA11) Menkes Disease (ATP7A) 1 L06133 + putative Cu++-transporting P-type ATPase metallothionein 2A (MT2A) 1 V00594 + + + + + metaxin 1 (MTX1) 1 U46920 + + + methionine 2 X68836 + + + + + adenosyltransferase II, alpha (MAT2A) methyl-CpG binding 1 Y10746 domain protein 1 (MBD1) (non-exact 59% aa) methylene tetrahydrofolate 2 X16396 + + + + + dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (MTHFD2) methylenetetrahydrofolate 1 J04031 + + + + + dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (MTHFD1) methyltransferase, putative 2 AJ224442 MHC antigen (HLA-B) 1 U14943 (=L42024) MHC class 1 region 2 AF055066 MHC class I antigen (HLA- 1 U70863 A2) MHC class I antigen (HLA- 1 U19736 A33) MHC class I antigen (HLA- 1 U38975 C) MHC class I antigen 1 U52813 B*5801 (HLA-B) MHC class I antigen HLA-A 2 AF015930 (HLA-A) MHC class I antigen HLA-A 1 U36687 (HLA-A-2402 allele) MHC class I antigen HLA- 2 X13112 A11K MHC class I antigen HLA-B 1 U67331 (B*0801 variant) (=AF028596) MHC class I antigen HLA-B 1 U67330 (B*0801 variant) (=U88254) MHC class I antigen HLA-B 1 AF017328 (B*48 allele) MHC class I antigen HLA-B 1 AF014770 (HLA-B*1502 allele) MHC class I antigen HLA-B 1 U58643 (HLA-B*40MD) MHC class I antigen HLA-B 1 AF028596 (HLA-B*4103 allele) MHC class I antigen HLA-B 1 AF035648 gene (HLA-B*4402 variant allele) MHC class I antigen HLA-B 1 U52175 GN00110-B*3910 MHC class I antigen HLA- 1 D83030 Cw*04011 MHC class I antigen 1 U56434 R69772 HLA-A (A*0302) MHC class I antigen 1 U58469 SHCHA (HLA-B*4403 variant) MHC class I 1 U06697 histocompatibility antigen (HLA-B) (clone C21/14) MHC class I HLA B71 2 L07950 MHC class I HLA-A 1 Flp (Aw33.1) MHC class I HLA-B 1 U18660 MHC class I HLA-B (HLA- 1 U18661 B-07ZEL allele) (=X86704) MHC class I HLA-B (HLA- 1 U28759 B-08NR allele) MHC class I HLA-B*3512 1 L76094 MHC class I HLA-B41 3 U17572 variant (=U17572) MHC class I HLA-B44.2 1 M24038 chain MHC class I HLA-B51- 1 L41086 cd3.3 MHC class I HLA-C allele 2 Z33459 MHC class I HLA-Cw*0304 1 D64150 (=M84172; M99389) MHC class I HLA-Cw*0803 3 Z15144 MHC class I HLA-Cw6 1 M28206 MHC class I HLA-J antigen 1 L56139 MHC class I lymphocyte 1 M19670 antigen A2 (A2.1) variant DK1 MHC class I mic-B antigen 1 X91625 MHC class I polypeptide- 1 L14848 + related sequence A (MICA) MHC class I protein HLA-C 1 U61274 heavy chain (C*0701new allele) (=AF017331) MHC class II DNA 1 L18885 Sequence (clone A37G7- 1C11) MHC class II DQ-alpha 1 M16995 + + + + associated with DRw6, DQw1 protein MHC class II DQ-beta 2 M17564 + + + associated with DR2, DQw1 protein MHC class II HAL-DQ- 1 M33842 LTR5 (DQ, w8) DNA fragment, long terminal repeat region MHC class II hla-dr alpha- 1 J00195 chain (=J00197; M60334; K011171; J00194; M60333; X00274) MHC class II HLA-DRB1 1 AF007883 MHC class II HLA-DRw11- 1 M21966 beta-I chain (DRw11.3) MHC class II lymphocyte 1 M23907 antigen (DPw4-beta-1) MHC CLASS II 1 P33076 TRANSACTIVATOR CIITA (non-exact 57%) MHC HLA-E2.1 (=X87679) 1 M32507 MHC HLA-E2.1 (alpha-2 1 M32507 domain) (low match) Mi-2 autoantigen 240 kDa 1 U08379 protein (non-exact 84%) microsomal stress 70 1 U04735 protein ATPase core (stch) microtubule-associated 1 U19727 + + + + + protein 4 (MAP4) microtubule-associated 1 X73882 protein 7 (MAP7) mineralocorticoid receptor 2 M16801 + + + (aldosterone receptor) (MLR) minichromosome 1 X62153 + + + + maintenance deficient (S. cerevisiae) 3 (MCM31) minichromosome 1 AB011144 + + + + maintenance deficient (S. cerevisiae) 3-associated protein (MCM3AP) minichromosome 2 X74795 + + + + + + maintenance deficient (S. cerevisiae) 5 (cell division cycle 46) (MCM5) mitochondiral cytochrome b 1 AF042517 (CYTB) mitochondrial 16S rRNA 11 Z70759 mitochondrial ATP 2 X59066 synthase (F1-ATPase) alpha subunit mitochondrial ATP 1 X69907 synthase c subunit (P1 form) mitochondrial cytochrome b 6 AF042508 (CYTB) mitochondrial cytochrome b 1 AB006202 small subunit of complex II mitochondrial 1 P00395 CYTOCHROME C OXIDASE POLYPEPTIDE I mitochondrial 1 P00403 CYTOCHROME C OXIDASE POLYPEPTIDE II mitochondrial cytochrome 2 P00403 C oxidase subunit II mitochondrial cytochrome 5 U12691 oxidase subunit II (COII) (=U12692 Hsa4 mitochondrion cytochrome oxidase subunit II) mitochondrial DNA loop 1 X89763 attachment sequences (clone LAS34) mitochondrial DNA 1 U94703 + polymerase accessory subunit precursor (MtPolB) nuclear gene encoding mitochondrial protein, mitochondrial DNA, 1 X93334 complete genome mitochondrial genes for 8 V00710 several tRNAs (Phe, Val, Leu) and 12S and 16S ribosomal RNAs. mitochondrial genes for 3 V00660 tRNA (Phe) and 12S rRNA (fragment) mitochondrial inner 1 AF106622 membrane preprotein translocase Tim17a mitochondrial isolate Afr7 1 AF042503 cytochrome b(CYTB) mitochondrial loop 1 X89843 attachment sequence (clone LAS88) mitochondrial NADH 14 AF014893 dehydrogenase subunit 2 (ND2) mitochondrial translational 1 L34600 + + + + initiation factor 2 (MTIF2) mitochondrion cytochrome b 1 U09500 mitogen inducible gene 1 Z24725 + + + + mig-2 mitogen inducible gene 1 Z24725 mig-2 (non-exact, 71%) mitogen-activated protein 2 U43784 + + + + kinase-activated protein kinase 3 (MAPKAPK3) MLN51 2 X80199 + + + + + MLN64 (=D38255 CAB1) 1 X80198 + + + + moesin (MSN) 14 M69066 + + + + + monocytic leukaemia zinc 2 U47742 + + + + finger protein (MOZ) MOP1 ( ) 2 U29165 motor protein (Hs.78504) 2 D21094 + + + + + mouse double minute 2, 1 U39736 + + human homolog of; p53- binding protein (MDM2) M-phase phosphoprotein 6 1 X98263 + + + + (MPP-6) M-phase phosphoprotein, 1 X98260 mpp11 MPS1 1 L20314 Mr 110,000 antigen 2 D64154 + + + + MRC OX-2, V-like region 1 X05324 (=M17227) mu-adaptin-related protein- 1 Y08387 2; mu subunit of AP-4 (MU- ARP2) multifunctional polypeptide 1 X53793 + + + + + similar to SAICAR synthetase and AIR carboxylase (ADE2H1) murine leukemia viral (bmi- 1 L13689 + + + 1) oncogene homolog (BMI1) mutant (Daudi) beta2 - 44 X07621 microglobulin mutated in colorectal 1 M62397 + + + cancers (MCC) myeloid cell leukemia 9 L08246 + + + + + + sequence 1 (BCL2-related) (MCL1) myeloid cell nuclear 11 M81750 + + differentiation antigeN (MNDA) myeloid differentiation 4 U70451 + + + + primary response gene (88) (MYD88) myeloid leukemia factor 2 3 U57342 + + + (MLF2) myeloid/lymphoid or mixed- 8 U89867 + + + + lineage leukemia (trithorax (Drosophila) homolog); translocated to, 7 (MLLT7) MYH9 (cellular myosin 1 M81105 heavy chain) myomesin (M-protein) 2 1 X69089 (165 kD) (MYOM2) myosin IE (MYO1E) 11 X98411 + + myosin light chain kinase 1 U48959 + + + + (MLCK) myosin phosphatase, 2 D87930 + + + + target subunit 1 (MYPT1) myosin regulatory light 2 D50372 chain (=U26162) myosin VIIa (low match 71) 1 U55208 myosin, heavy polypeptide 3 M81105 + + + + + 9, non-muscle (MYH9) myosin, light polypeptide, 6 X54304 + + + + + + regulatory, non-sarcomeric (20 kD) (MLCB) myosin-I beta 1 X98507 + + + + + myristoylated alanine-rich 1 D10522 + + protein kinase C substrate (MARCKS, 80K-L) (MACS) myxovirus (influenza) 1 M30817 + + + + + resistance 1, homolog of murine (interferon-inducible protein p78) (MX1) myxovirus (influenza) 3 M30818 + resistance 2, homolog of murine (MX2) N-acetylgalactosaminidase, 2 M62783 + + + + alpha-(NAGA) N-acetylglucosamine 1 L03532 + + + + receptor 1 (thyroid) (NAGR1) NACP/alpha-synuclein 2 U46896 N-acylaminoacyl-peptide 1 D38441 + + + + hydrolase (APEH) N-acylsphingosine 11 U47674 + + + + + amidohydrolase (acid ceramidase) (ASAH) NAD+-specific isocitrate 1 U49283 + + + + + + dehydrogenase beta subunit precursor (encoding mitochondrial protein) NADH dehydrogenase 1 U53468.1 + + + + + + (ubiquinone) 1 alpha subcomplex, 5 (13 kD, B13) (NDUFA5) NADH dehydrogenase 1 AF047181 + + + + + (ubiquinone) 1 beta subcomplex, 5 (16 kD, SGDH) (NDUFB5) NADH dehydrogenase 1 AF050640 + + + + + (ubiquinone) Fe—S protein 2 (49 kD) (NADH-coenzyme Q eductase) (NDUFS2) NADH dehydrogenase 1 M22538 + + + + (ubiquinone) flavoprotein 2 (24 kD) (NDUFV2) NADH:ubiquinone 2 AF053070 + + + + + + dehydrogenase 51 kDa subunit (NDUFV1) NADH-CYTOCHROME B5 1 P00387 REDUCTASE (B5R) (50% aa) NADH-UBIQUINONE 1 P03886 OXIDOREDUCTASE CHAIN 1 Nardilysin (N-arginine 2 U64898 + + + + + dibasic convertase) (NRD1) nascent-polypeptide- 5 X80909 + + + + associated complex alpha polypeptide (NACA) natural killer cell group 7 8 S69115 + + sequence (NKG7) natural killer cell transcript 19 M32011 + 4 (NK4) natural killer-associated 1 U30274 + blood only transcript 3 (NKAT3) natural killer-associated 1 AF022045 + blood only transcript 5 (NKAT5) natural killer-tumor 1 L04288 B + + + recognition sequence (NKTR) N-deacetylase/N- 2 AF042084 + + + + sulfotransferase (heparan glucosaminyl) 2 (NDST2) Ndr protein kinase 3 Z35102 + Nedd-4-like ubiquitin- 1 U96113 protein ligase WWP1 nel (chicken)-like 2 3 D83018 + + (NELL2) N-ethylmaleimide-sensitive 1 U39412 + + factor attachment protein, alpha (NAPA) N-ethylmaleimide-sensitive 1 U78107 + + + factor attachment protein, gamma (NAPG) neural precursor cell 3 X92544 + + + + + high in testis expressed, developmentally down- regulated 5 (NEDD5) neural precursor cell 1 D23662 + + + + + + expressed, developmentally down- regulated 8 (NEDD8) neuregulin 1 (NRG1) 1 U02330 + + + neuroblastoma RAS viral 4 AB020692 + + + + + (v-ras) oncogene homolog (NRAS) Neuroblastoma RAS viral 1 X68286 (v-ras) oncogene homolog (NRAS) (low match) Neurofibromin 2 (bilateral 1 S73853 + + acoustic neuroma) (NF2) neuronal apoptosis 2 U19251 + + + + inhibitory protein (NAIP) neuronal cell adhesion 1 AB002341 + + + + molecule (NRCAM) neuropathy target esterase 1 AJ004832 + + + + (NTE) neuropeptide Y3 receptor, 1 D28433 5′UTR (low score) neurotrophic tyrosine 14 X03541 + + + + + + kinase, receptor, type 1 (NTRK1) neutrophil cytosolic factor 4 2 U50720 (40 kD) NG31 1 AF129756 NGAL (=X83006) 1 X99133 nibrin (NBS) 1 AF051334 NIK 1 AB014587 + + + + Ninjurin 1; nerve injury- 1 U72661 + + + + induced protein-1 nitrilase 1 (NIT1) 1 AF069987 (=AF069984) NKG2-D (low match) (non- 1 X54870 exact, 58%) Nmi 1 U32849 N-myristoyltransferase 1 1 AF043324 + + + + + (NMT1) No arches-like (zebrafish) 1 U79569 + + + + zinc finger protein (NAR) non-histone chromosome 1 D50420 + + + + + + protein 2 (S. cerevisiae)- like 1 (NHP2L1) non-muscle (fibroblast) 1 tropomyosin non-muscle alpha-actinin 1 U48734 non-muscle myosin alkali 3 M22918 + + + + + + High in fetal adrenal light chain (Hs.77385) gland and BPH stroma non-neuronal enolase (EC 1 X16289 4.2.1.11) non-receptor tyrosine 1 M33689 phosphatase 1 normal keratinocyte 3 X53778 + + + + + + high in many libraries substraction library mRNA, clone H22a notch group protein (N) 3 M99437 novel protein 1 X99961 novel T-cell activation 1 X94232 + + + + protein N-ras protein NRU 1 A60196 N-sulfoglucosamine 1 U60111 + + sulfohydrolase (sulfamidase) (SGSH) nsulin induced gene 1 1 U96876 + + + + + + (INSIG1) ntegrin, alpha 4 (antigen 3 L12002 + + CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA14) nterferon, gamma-inducible 1 M63838 + + + + + protein 16 (IFI16) nterleukin 1, beta (IL1RB) 1 M15330 nuclear antigen H731-like 2 U83908 + + + + protein nuclear antigen Sp100 4 U36501 + + + + (SP100) Nuclear antigen Sp100 1 P23497 (SP100) (85% aa) Nuclear antigen Sp100 1 P23497 (SP100) (89% aa) nuclear autoantigenic 1 M97856 + + sperm protein (histone- binding) (NASP) nuclear corepressor KAP-1 1 U78773 (KAP-1) (=U95040; X97548 TIF1beta zinc finger protein) Nuclear domain 10 protein 4 U22897 + + + + + + (NDP52) Nuclear factor (erythroid- 1 S74017 + + + + + derived 2)-like 2 (NFE2L2) Nuclear factor of kappa 2 M58603 + + + + light polypeptide gene enhancer in B-cells 1 (p105) (NFKB1) nuclear factor of kappa 3 M69043 + + + + light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA) nuclear factor related to 1 U08191 + + + + kappa B binding protein (NFRKB) nuclear mitotic apparatus 3 Z11583 + + + + + + protein 1 (NUMA1) nuclear receptor 1 X97674 coactivator 2 (GRIP1) nuclear receptor 2 AF010227 + + + + coactivator 3 (AIB3) nuclear receptor 22 X77548 + + + + + coactivator 4 (ELE1) nuclear receptor interacting 1 X84373 + + + protein 1 (NRIP1) nuclear respiratory factor 1 1 U02683 B + + (NRF1) nuclear RNA helicase, 4 U90426 + + + + + DECD variant of DEAD box family (DDXL) nuclear transcription factor 1 X59711 B Y, alpha (NFYA) nuclear transcription factor, 3 U15306 + + + X-box binding 1 (NFX1) nuclear transport factor 2 1 X07315 + + + + + (placental protein 15) (PP15) nucleobindin (=M96824) 1 U31336 nucleobindin 1 (NUCB1) 2 M96824 + + + + + nucleolar phosphoprotein 1 Z34289 + + p130 (P130) nucleolar protein (KKE/D 1 Y12065 + + + + + repeat) (NOP56) nucleolar protein (MSP58) 1 AF015308 nucleolar protein 1 (120 kD) 1 M32110 + + (NOL1) nucleolar protein p40 1 U86602 + + + + + nucleolin (NCL) 2 M60858 + + + + + nucleophosmin (nucleolar 14 M28699 + + + + + phosphoprotein B23, numatrin) (NPM1) nucleophosmin-retinoic 1 U41742 acid receptor alpha fusion protein NPM-RAR long form nucleoporin (NUP358) 2 L41840 (=D42063 RanBP2 (Ran- binding protein 2)) nucleoporin 153 kD 1 Z25535 (NUP153) nucleoporin 98 kD (NUP98) 1 U41815 nucleosome assembly 1 D28430 protein nucleosome assembly 1 M86667 + + + + protein 1-like 1 (NAP1L1) nucleosome assembly 2 U77456 + + + + + protein 1-like 4 (NAP1L4) nucleosome assembly 1 D28430 protein, 5′UTR olfactory receptor (OR7- 1 U86281 141) OLFACTORY RECEPTOR- 1 P34982 LIKE PROTEIN HGMP07E (OR17-4) (non-exact 65%) oligodendrocyte myelin 7 L05367 + glycoprotein (OMG) O-linked N- 1 U77413 + + + + + acetylglucosamine (GlcNAc) transferase (UDP-N- acetylglucosamine:polypeptide- N-acetylglucosaminyl transferase) (OGT) oncofetal trophoblast 1 A53531 glycoprotein 5T4 precursor (non-exact 55%) Oncogene TIM (TIM) (non- 1 U02082 exact 84%) ORF (Hs.77868) 1 M68864 + + + + + + ORF1; MER37; putative 1 U49973 transposase similar to pogo element Length = 454 origin recognition complex, 2 U27459 + subunit 2 (yeast homolog)- like (ORC2L) origin recognition complex, 1 AF022108 subunit 4 (yeast homolog)- like (ORC4L) (low match) ornithine aminotransferase 2 M23204 + + + (gyrate atrophy) (OAT) ornithine decarboxylase 1 M20372 (ODC) ornithine decarboxylase 11 D78361 + + + + + + High in pancreas, antizyme, ORF 1 and ORF 2 and activated T cells orphan receptor 2 U07132 + + + + + (Hs.100221) OS-9 precurosor 6 AB002806 + + + + + + osteonectin (=X82259 BM- 1 D28381 40) ovel centrosomal protein 1 AB008515 + + + + RanBPM (RANBPM) over-expressed breast 1 L34839 tumor protein oviductal glycoprotein 1, 1 U09550 + + + 120 kD (OVGP1) oxidase (cytochrome c) 1 X80695 + + + + + assembly 1-like (OXAIL) oxoglutarate 4 D10523 T + + + + dehydrogenase (lipoamide) (OGDH) oxysterol binding protein 1 M86917 + + + (OSBP) OZF 1 X70394 + + + + OZF (non-exact zinc finger) 1 X70394 p21/Cdc42/Rac1-activated 2 U51120 + + + kinase 1 (yeast Ste20- related) (PAK1) P35-related protein 1 D63392 (=S80990 ficolin) p40 1 U93569 p40phox (=U50720) 1 X77094 P47 LBC oncogene 4 U03634 p53-induced protein 1 AF010315 + + + + (PIG11) p54nrb (low match) 1 Y11287 p62 nucleoporin 1 X58521 p63 mRNA for 1 X69910 + + + + + transmembrane protein PAC clone DJ0701O16 1 Q07108 from 7q33-q36 (non-exact 54%) palmitoyl-protein 10 U44772 + + + + thioesterase (ceroid- lipofuscinosis, neuronal 1, infantile; Haltia-Santavuori disease) (PPT) papillary renal cell 1 X99720 + + + + + + carcinoma (translocation- associated) (PRCC) PAR protein 1 AF115850 + + partial EST (clone c-1gh04) 1 Z43627 PAX3/forkhead 1 U02368 transcription factor gene fusion paxillin (PXN) 4 D86862 + + + + PBK1 protein 2 AJ007398 + + + + + PBS-EST (nz92e01.s1 1 AA732534 NCI_CGAP_GCB1 clone IMAGE: 1302936) (low score) PDZ domain protein 1 AJ224747 + + + (Drosophila inaD-like) (INALD) PEBP2aC Runt domain 1 Z38108 encoding gene (=Z35728) peptidase D (PEPD) 1 J04605 peptidylprolyl isomerase A 3 Y00052 + + + + + high in many libraries (cyclophilin A) (PPIA) peptidylprolyl isomerase D 2 L11667 T + + + + (cyclophilin D) (PPID) peptidylprolyl isomerase E 1 AF042386 + + + + (cyclophilin E) (PPIE) PERB11.1 (=U56942 MHC 1 U69630 class I chain-related protein A) perforin 1 (preforming 14 M28393 protein) (PRF1) peroxisomal acyl-CoA 2 X86032 thioesterase (PTE1) Peroxisomal acyl- 1 X71440 + + + + + coenzyme A oxidase peroxisomal farnesylated 1 X75535 + + + + + protein (PXF) phorbol-12-myristate-13- 1 D90070 B, W acetate-induced protein (PMAIP1) phosphate carrier 1 X77337 (mitochondrial gene?) Phosphate carrier, 3 X60036 + + + + + mitochondrial (PHC) phosphate 1 L28957 T + + cytidylyltransferase 1, choline, alpha isoform (PCYT1A) PHOSPHATIDATE 1 Q92903 CYTIDYLYLTRANSFERASE (CDP-DIGLYCERIDE) phosphatidylinositol 3- 2 U57843 kinase delta catalytic subunit phosphatidylinositol 4- 3 AB005910 + + + + + kinase, catalytic, beta polypeptide (PIK4CB) phosphatidylinositol glycan, 1 L19783 + + + + + class H (PIGH) phosphatidylinositol 2 D30037 transfer protein (PI-TPbeta) phosphatidylinositol 2 X98654 B, T + transfer protein, lymphoma membrane-associated (PITPNM) phosphatidylinositol 1 X98654 transfer protein, membrane-associated (PITPNM) (non-exact 64%) phosphatidylinositol-4- 1 U14957 + + phosphate 5-kinase, type II, alpha (PIP5K2A) phosphatidylinositol-4- 1 U85245 + + + + phosphate 5-kinase, type II, beta (PIP5K2B) phosphodiesterase 7A 1 L12052 B, W + + + (PDE7A) phosphodiesterase IB 1 U56976 ONLY (PDES1B) phosphoglucomutase 1 2 M83088 + + + + (PGM1) phosphogluconate 1 U30255 + dehydrogenase (PGD) phosphoglycerate kinase 1 12 V00572 (PGK1) phosphoglycerate mutase 3 J04173 + + + + + + 1 (brain) (PGAM1) phosphoglycerate mutase 1 M55673 + + + 2 (muscle) (PGAM2) phosphoinositide-3-kinase, 1 Z29090 + + + catalytic, alpha polypeptide (PIK3CA) phosphoinositide-3-kinase, 4 U86453 + + + + catalytic, delta polypeptide (PIK3CD) phosphoinositide-3-kinase, 1 X83368 catalytic, gamma polypeptide (PIK3CG) phospholipase C 1 X14034 phospholipase C, delta 1 2 U09117 + + + + (PLCD1) phospholipase C, gamma 1 1 M34667 + + + + + (formerly subtype 148) (PLCG1) phospholipid scramblase 1 AF008445 phosphoribosyl 1 D61391 + + + pyrophosphate synthetase- associated protein 1 (PRPSAP1) phosphoribosylglycinamide 3 X54199 + + + + + formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (GART) phosphorylase kinase, 3 D38616 + + + + + alpha 2 (liver), glycogen storage disease IX (PHKA2) phosphorylase, glycogen; 1 U47025 + + + + brain (PYGB) phosphorylase, glycogen; 1 U47025 brain (PYGB) (low match, non-exact, 75%) phosphorylase, glycogen; 1 Y15233 + + + + liver (Hers disease, lycogen storage disease type VI) (PYGL) phosphorylation regulatory 2 protein HP-10 phosphotidylinositol 1 D30036 + + + + + transfer protein (PITPN) pigment epithelium-derived 1 U29953 + + + + + + factor (PEDF) pim-1 oncogene (PIM1) 1 M24779 + + + + pinin, desmosome 1 U77718 B, associated protein (PNN) monocyte, T lymphoma placenta (Diff33) 5 U49188 + + + + placenta (Diff33) (non- 1 U49188 exact, 69%) placenta (Diff48) 18 U49187 + placenta (Diff48) (low 1 U49187 match) placenta(Diff48) (low 1 U49187 match) plasminogen activator, 1 X74039 + + + urokinase receptor (PLAUR) platelet factor 4 (PF4) 1 M25897 + + platelet/endothelial cell 8 M37780 + + + + + adhesion molecule (CD31 ntigen) (PECAM1) platelet-activating factor 4 U89386 + + + acetylhydrolase 2 (40 kD) (PAFAH2) platelet-activating factor 1 U72342 + + + + + + acetylhydrolase, isoform lb, alpha subunit (45 kD) (PAFAH1B1) platelet-activating factor 1 D10202 + + receptor (PTAFR) pleckstrin (PLEK) 10 X07743 + + + pleckstrin (PLEK) (low 1 X07743 match) pleckstrin homology, Sec7 4 M85169 + + + + and coiled/coil domains 1(cytohesin 1) (PSCD1) pleckstrin homology, Sec7 4 L06633 + + and coiled/coil domains, binding protein (PSCDBP) pM5 protein 1 X57398 + + + + + PMP69 2 Y14322 poly (ADP-ribose) 1 X56140 polymerase (NAD (+) ADP- ribosyltransferase) (=X16674) poly(A) polymerase (PAP) 1 X76770 + + + + + poly(A)-binding protein-like 19 Y00345 + + + + + + 1 (PABPL1) poly(rC)-binding protein 1 3 X78137 + + + + + + (PCBP1) polyadenylate binding 1 U75686 protein polycystic kidney disease 1 5 U24498 (autosomal dominant) (PKD1) polymerase (DNA 1 D29013 + + + directed), beta (POLB) polymerase (DNA 6 D84103 directed), gamma (POLG) polymerase (RNA) II (DNA 1 X63564 + + + + + + directed) polypeptide A (220 kD) (POLR2A) polymyositis/scleroderma 1 L01457 + + + + + + autoantigen 2 (100 kD) (PMSCL2) polypyrimidine tract binding 1 X65372 + + + + + + protein (heterogeneous nuclear ribonucleoprotein I) (PTB) positive regulator of 3 U13021 + programmed cell death ICH-1L (Ich-1) postmeiotic segregation 1 M16514 + + + + + increased 2-like 12 (PMS2L12) postmeiotic segregation 1 U38964 + + + + + increased 2-like 8 (PMS2L8) potassium inwardly- 1 D87291 + + rectifying channel, subfamily J, member 15 (KCNJ15) potassium voltage-gated 1 AF051426 + + + + channel, KQT-like subfamily, member 1 (KCNQ1) POU domain, class 2, 1 Z49194 + associating factor 1 (POU2AF1) POU domain, class 2, 2 X13403 + + transcription factor 1 (POU2F1) PPAR binding protein 1 Y13467 + + + + + (PPARBP) PPAR gamma2 1 D83233 pre-B-cell colony- 8 U02020 enhancing factor (PBEF) prefoldin 1 (PFDN1) 1 Y17392 + + + + + + prefoldin 5 (PRFLD5) 3 D89667 B + + + prefoldin subunit 3 1 Y17394 (=U96759 von Hippel- Lindau binding protein (VBP-1)) pregnancy-associated 1 U28727 + + high in placenta plasma protein A (PAPPA) pre-mRNA splicing factor 1 U08815 + + + + + SF3a (60 kD), similar to S. cerevisiae PRP9 (spliceosome-associated protein 61) (SF3A60) pre-mRNA splicing factor 1 U08815 SF3a (60 kD), similar to S. cerevisiae PRP9 (spliceosome-associated protein 61) (SF3A60) (low score) pre-mRNA splicing factor 2 D28423 SRp20, 5′UTR preprotein translocase 3 X97544 + + + + + (TIM17) prion protein 1 X82545 prion protein (p27-30) 1 M13899 + + + + (Creutzfeld-Jakob disease, Gerstmann-Strausler- Scheinker syndrome, fatal familial insomnia) (PRNP) pristanoyl-CoA oxidase 1 Y11411 (low match) pristanoyl-CoA oxidase 1 Y11411 (low score) procollagen-lysine, 2- 1 M98252 + + + + oxoglutarate 5-dioxygenase (lysine hydroxylase, Ehlers- Danlos syndrome type VI) (PLOD) procollagen-proline, 2- 1 M24486 + + + + + + oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 1 (P4HA1) procollagen-proline, 2- 4 X05130 + + + + + + oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55) (P4HB) profilin 1 (PFN1) 1 J03191 + + + + + + progesterone receptor- 2 U28918 + associated p48 protein (P48) prohibitin (PHB) 1 S85655 + + + + + proliferating cell nuclear 3 J04718 + + + + + antigen (PCNA) proliferation-associated 4 L19184 + + + + + + gene A (natural iller- enhancing factor A) (PAGA) proline-rich protein BstNI 1 S62936 subfamily 2 (PRB2) (non- exact, 43% aa) proline-serine-threonine 1 U94778 phosphatase interacting protein 1 (PSTPIP1) prolyl endopeptidase 2 X74496 + + + (PREP) prolylcarboxypeptidase 5 L13977 + + + + + (angiotensinase C) (PRCP) promyelocytic leukemia 1 M80185 + + + + + (PML) properdin P factor, 4 X57748 + complement (PFC) pro-platelet basic protein 1 M54995 + + + (includes platelet basic protein, beta- thromboglobulin, connective tissue-activating peptide III, neutrophil-activating peptide-2) (PPBP) pro-platelet basic protein 7 M54995 + + + (includes platelet basic protein, beta- thromboglobulin, connective tissue-activating peptide III, neutrophil- activating peptide-2) (PPBP) proprotein convertase 4 U40623 subtilisin/kexin type 7 (PCSK7) prosaposin (variant 89 D00422 + + + + + + Gaucher disease and variant metachromatic leukodystrophy) (PSAP) prostaglandin- 1 U63846 B + + + endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1) prostaglandin- 2 L15326 endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2) prostaglandin- 1 D64068 endoperoxide synthase-1 (=L08404; U84208) (all promoters) prostate carcinoma tumor 2 L78132 antigen (pcta-1) protease inhibitor 1 (anti- 17 K02212 + + + + + high in many libraries elastase), alpha-1- antitrypsin (PI) protease inhibitor 2 (anti- 1 M93056 + + elastase), monocyte/neutrophil (ELANH2) (low match) proteasome (prosome, 3 L02426 B + + + macropain) 26S subunit, ATPase, 1 (PSMC1) proteasome (prosome, 1 M34079 + + + + + macropain) 26S subunit, ATPase, 3 (PSMC3) proteasome (prosome, 2 AF020736 macropain) 26S subunit, ATPase, 4 (PSMC4) proteasome (prosome, 5 L38810 + + + + + + macropain) 26S subunit, ATPase, 5 (PSMC5) proteasome (prosome, 2 D78275 + + + + + macropain) 26S subunit, ATPase, 6 (PMSC6) proteasome (prosome, 1 AF001212 T + + macropain) 26S subunit, non-ATPase, 11 (PSMD11) proteasome (prosome, 2 D78151 + + + macropain) 26S subunit, non-ATPase, 2 (PSMD2) proteasome (prosome, 1 S79862 T + + + macropain) 26S subunit, non-ATPase, 5 (PSMD5) proteasome (prosome, 1 D50063 + + + + high in many libraries macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) (PMSD7) proteasome (prosome, 1 AB003103 + + + + macropain) 26S subunit, on-ATPase, 12 (PMSD12) proteasome (prosome, 3 L07633 + + + + + macropain) activator subunit 1 (PA28 alpha) (PSME1) proteasome (prosome, 2 D00762 + + + + macropain) subunit, alpha type, 3 (PSMA3) proteasome (prosome, 3 X61970 + + + + + macropain) subunit, alpha type, 5 (PSMA5) proteasome (prosome, 3 AF054185 + + + + + macropain) subunit, alpha type, 7 (PSMA7) proteasome (prosome, 1 AF022815 macropain) subunit, alpha type, 7 (PSMA7) (low match) proteasome (prosome, 1 D00761 + + + + + + macropain) subunit, beta type, 1 (PSMB1) proteasome (prosome, 1 X71874 + + + + + macropain) subunit, beta type, 10 (PSMB10) proteasome (prosome, 1 D29012 + + + + macropain) subunit, beta type, 6 (PMSB6) proteasome (prosome, 1 U17497 + + + + + macropain) subunit, beta type, 8 (large multifunctional protease 7) (PSMB8) proteasome (prosome, 3 Z14977 + + + macropain) subunit, beta type, 9 (large multifunctional protease 2) (PSMB9) proteasome (prosome, 1 D38048 + + + + + + macropain) subunit, beta type, 7 (PSMB7) protective protein for beta- 3 M22960 + + + + + + galactosidase (galactosialidosis) (PPGB) protein A alternatively 1 U47925 + spliced form 2 (A-2) protein activator of the 1 AF072860 + + + + high in testis interferon-induced protein kinase (PACT) protein disulfide isomerase- 2 D49489 + + + + + + related protein (P5) protein 1 L25441 + + + geranylgeranyltransferase type I, beta subunit (PGGT1B) protein homologous to 20 M24194 + + + + + + high in many libraries chicken B complex protein, guanine nucleotide binding (H12.3) protein kinase A anchoring 1 AF037439 + protein protein kinase C substrate 2 U50317 + + + + + 80K-H (PRKCSH) protein kinase C, beta 1 6 X06318 + + + + + (PRKCB1) protein kinase C, delta 1 D10495 + + + + + (PRKCD) protein kinase C, eta 1 M55284 + + (PRKCH) protein kinase C, mu 1 X75756 (PRKCM) (non-exact 78%) Protein kinase C-like 1 2 D26181 + + + + + (PRKCL1) protein kinase, AMP- 1 U42412 B, T + + activated, gamma 1 non- lymphoma catalytic subunit (PRKAG1) protein kinase, cAMP- 4 M18468 + + + + + dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A) protein kinase, DNA- 1 U47077 + + + + activated, catalytic polypeptide (PRKDC) protein kinase, mitogen- 1 Z11695 B + + activated 1 (MAP kinase 1; p40, p41) (PRKM1) protein kinase, mitogen- 1 L77964 + + + + activated 6 (extracellular signal-regulated kinase, p97) (PRKM6) protein kinase, mitogen- 1 U66839 + + + + + activated, kinase 3 (MAP kinase kinase 3) (PRKMK3) protein phosphatase 1, 5 M63960 + + + + + + catalytic subunit, alpha isoform (PPP1CA) protein phosphatase 1, 3 Y13247 + + + + regulatory subunit 10 (PPPR10) protein phosphatase 1, 2 Z50749 + + + + + + regulatory subunit 7 (PPP1R7) protein phosphatase 2 1 X12656 + + + + + + (formerly 2A), catalytic subunit, beta isoform (PPP2CB) protein phosphatase 2 1 L07590 + + + (formerly 2A), regulatory subunit B″ (PR 72), alpha isoform and (PR 130), beta isoform (PPP2R3) protein phosphatase 2, 2 L42373 + + + + + regulatory subunit B (B56), alpha isoform (PPP2R5A) protein phosphatase 2, 3 D78360 + + + + regulatory subunit B (B56), delta isoform (PPP2R5D) protein phosphatase 2, 1 D26445 + + + + + regulatory subunit B (B56), gamma isoform (PPP2R5C) protein phosphatase 2A 5 J02902 + + + + + regulatory subunit alpha- isotype (alpha-PR65) protein phosphatase 4 2 AF097996 + + + + + (formerly X), catalytic subunit (PPP4C) protein tyrosine kinase 2 4 L49207 + + + beta (PTK2B) protein tyrosine 1 X54134 phosphatase epsilon protein tyrosine 2 L48723 + + + + + phosphatase type IVA, member 2 (PTP4A2) protein tyrosine 1 M31724 + + + + phosphatase, non-receptor type 1 (PTPN1) protein tyrosine 1 M93425 + + + + high in testis phosphatase, non-receptor type 12 (PTPN12) protein tyrosine 1 M93425 phosphatase, non-receptor type 12 (PTPN12) (non- exact, 70%) protein tyrosine 2 M25393 + + + + phosphatase, non-receptor type 2 (PTPN2) protein tyrosine 1 M68941 + + + phosphatase, non-receptor type 4 (megakaryocyte) (PTPN4) protein tyrosine 7 M74903 + + + + + phosphatase, non-receptor type 6 (PTPN6) protein tyrosine 1 D11327 + + + phosphatase, non-receptor type 7 (PTPN7) protein tyrosine 1 M34668 + + + + + phosphatase, receptor type, alpha polypeptide (PTPRA) protein tyrosine 44 Y00638 + + + + phosphatase, receptor type, c polypeptide (PTPRC) protein tyrosine 1 X58288 + + + + phosphatase, receptor type, M (PTPRM) protein tyrosine 2 U81561 + + + phosphatase, receptor type, N polypeptide 2 (PTPRN2) protein with polyglutamine 1 U94836 + + + + + repeat (ERPROT213-21) protein-kinase, interferon- 1 U28424 + + + + + inducible double stranded RNA dependent inhibitor (PRKRI) protein-L-isoaspartate (D- 4 D13892 + + aspartate) O- methyltransferase (PCMT1) proteoglycan 1, secretory 7 J03223 + + + granule (PRG1) prothymosin, alpha (gene 12 M14483 + + + + + + sequence 28) (PTMA) prp28, U5 snRNP 100 kd 7 AF026402 + + + + + protein (U5-100K) PRP4/STK/WD splicing 1 AF001687 + + + + factor (HPRP4P) PTK7 protein tyrosine 1 U40271 + + + + kinase 7 (PTK7) purinergic receptor P2X, 3 AF000234 + + + + ligand-gated ion channel, 4 (P2RX4) purinergic receptor P2X, 1 Y12851 + macrophage only ligand-gated ion channel, 7 (P2RX7) puromycin-sensitive 1 Y07701 + + + aminopeptidase (PSA) putative ATP(GTP)-binding 2 AJ010842 + + protein putative brain nuclearly- 1 AB018308 + + + + + targeted protein (KIAA0765) putative chemokine 1 D10923 + receptor; GTP-binding protein (HM74) putative dienoyl-CoA 1 AF030249 isomerase (ECH1) putative G-binding protein 1 AF065393 Putative human HLA class 1 U73477 B + + II associated protein I (PHAP1) Putative L-type neutral 1 AB007896 amino acid transporter (KIAA0436) putative mitochondrial 1 AF050198 space protein 32.1 PUTATIVE MUCIN CORE 1 Q04900 PROTEIN PRECURSOR 24 (MULTI- GLYCOSYLATED CORE PROTEIN 24) (MGC-24) (MUC-24) putative nucleic acid 2 X76302 + + + + + binding protein putative outer 1 U58970 + + + + mitochondrial membrane 34 kDa translocase Htom34 putative p150 (non-exact 1 U93568 88%) putative translation 1 L26247 + + + + + + High in moderately initiation factor (SUI1) differentiated colon adenocarcinoma putative tumor suppressor 1 AF061836 + + + + protein (123F2) pyrroline 5-carboxylate 1 M77836 + + + + + reductase pyruvate dehydrogenase 1 D90084 + + + + + (lipoamide) alpha 1 (PDHA1) pyruvate dehydrogenase 2 J03576 + + + + + (lipoamide) beta (PDHB) Pyruvate dehydrogenase 3 Y13145 + + complex, lipoyl-containing component X; E3-binding protein (PDX1) pyruvate kinase, muscle 11 M23725 + (PKM2) RAB, member of RAS 1 U18420 + + + + oncogene family-like (RABL) RAB1, member RAS 3 M28209 + + + + oncogene family (RAB1) RAB11A, member RAS 2 X56740 + + + + + high in spleen oncogene family (RAB11A) RAB11B, member RAS 1 D45418 + + oncogene family (Rab11B) RAB27A, member RAS 3 U38654 + oncogene family (RAB27A) RAB5B, member RAS 1 X54871 + + + + oncogene family (RAB5B) RAB6, member RAS 1 M28212 + + oncogene family (RAB6) RAB7, member RAS 1 X93499 + + + + + oncogene family (RAB7) RAB7, member RAS 2 D84488 + + + + oncogene family-like 1 (RAB7L1) RAB9, member RAS 1 U44103 oncogene family (RAB9) RAD50 (S. cerevisiae) 2 U63139 + + + homolog (RAD50) RAD51 (S. cerevisiae) 1 AF029669 + + + + homolog C (RAD51C) Radin blood group (RD) 2 L03411 + + + + RAE1 (RNA export 1, 3 U84720 + + + + + S. pombe) homolog (RAE1) ralA-binding protein 2 L42542 + + + + (RLIP76) RAN binding protein 2-like 2 AF012086 1 (RANBP2L1) Ran GTPase activating 3 X82260 + + + + + protein 1 (RANGAP1) RAN, member RAS 1 M31469 oncogene family (RAN) (low match) RanBP2 (Ran-binding 1 D42063 protein 2) (=U19248; L41840 sapiens nucleoporin (NUP358)) ransforming growth factor, 4 D50683 + + + + + beta receptor II (70-80 kD) (TGFBR2) RAP1A, member of RAS 10 M22995 + + + + + + oncogene family (RAP1A) RAR-related orphan 1 U16997 + receptor C (RORC) RAS guanyl releasing 1 Y12336 + + protein 2 (calcium and DAG-regulated) ras homolog gene family, 12 X05026 + + + + + + high in ovary member A (ARHA) ras homolog gene family, 1 X61587 + + + + member G (rho G) (ARHG) ras homolog gene family, 2 Z35227 + + + + member H (ARHH) ras inhibitor (RIN1) 2 M37191 + Ras-GTPase activating 2 AF053535 + + + + + protein SH3 domain- binding protein 2 (KIAA0660) Ras-GTPase-activating 3 U32519 + + + + + protein SH3-domain- binding protein (G3BP) ras-related C3 botulinum 11 M29871 + + toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2) RAS-RELATED PROTEIN 1 P09526 RAP-1B (GTP-BINDING PROTEIN SMG P21B) RBQ-1 1 X85133 + + + rearranged T cell receptor 1 L06891 beta variable region (TCRB) (=X58810) regulator of Fas-induced 1 AF057557 B + apoptosis (TOSO) regulator of G protein 1 AF073920 + signalling 6 (RGS6) regulator of G-protein 2 AF037195 + + + + signalling 14 (RGS14) regulator of G-protein 6 L13391 + + + + + signalling 2, 24 kD (RGS2) regulator of G-protein 1 O15539 signalling 5 (RGS5) (49% aa) regulatory factor X, 4 1 M69297 + + (influences HLA class II expression) (RFX4) regulatory factor X, 5 2 X85786 T + + + (influences HLA class II expression (RFX5) replication protein A1 1 M63488 + + + + + (RPA1) replication protein A3 1 L07493 (14 kD) (RPA3) (low match) reproduction 8 (D8S2298E) 1 D83767 + + + requiem, apoptosis 2 U94585 + + + + + response zinc finger gene (REQ) requiem, apoptosis 1 U94585 response zinc finger gene (REQ) (=AF001433) (low match) restin (Reed-Steinberg cell- 1 M97501 B, T + + expressed intermediate filament-associated protein) (RSN) retinoblastoma 1 (including 3 L11910 + + + + osteosarcoma) (RB1) retinoblastoma binding 1 AF087481 protein 2 homolog 1 (RBBP2H1) retinoblastoma-binding 1 S66427 + + protein 1 (RBBP1) retinoblastoma-binding 5 S66431 + + + + + protein 2 (RBBP2) retinoblastoma-binding 1 X71810 + + + + protein 4 (RBBP4) retinoblastoma-binding 1 X74262 + + + + protein 4 (RBBP4) retinoblastoma-binding 1 U35143 protein 7 (RBBP7) retinoblastoma-like 2 1 X76061 + + + + (p130) (RBL2) retinoic acid receptor 1 AF060228 + + + + responder (tazarotenenduced) 3 (RARRES3) retinoic acid receptor, 1 X06538 + + + alpha (RARA) retinoic acid responsive 1 U50383 + + + (NN8-4AG) retinoid X receptor beta 2 X66424 + + + + (RXR-beta) REV3 (yeast homolog)-like, 1 AF035537 catalytic subunit of DNA polymerase zeta (REV3L) Rho GDP dissociation 23 L07916 + + + + + + inhibitor (GDI) beta (ARHGDIB) Rho GTPase activating 2 X78817 + + protein 4 (ARHGAP4) Rho GTPase activating 1 P98171 protein 4 (ARHGAP4) (low match) Rho-associated, coiled-coil 1 AB014519 containing protein kinase 2 (ROCK2) ribonuclease 6 precursor 2 U85625 + + + + + + (RNASE6PL) ribonuclease 6 precursor 1 U85625 (RNASE6PL) (low match) ribonuclease, RNase A 1 X55988 + family, 2 (liver, eosinophil- derived neurotoxin) (RNASE2) ribonuclease/angiogenin 3 M36717 + + + + + inhibitor (RNH) ribonucleoside diphosphate 1 X65708 reductase M1 subunit ribonucleotide reductase 1 P31350 M2 polypeptide (non-exact 91%) ribophorin I (RPN1) 1 Y00281 + + + + + ribophorin II (RPN2) 1 Y00282 + + + + + + ribosomal 18S rRNA 3 M10098 ribosomal 28S RNA 1 M11167 ribosomal phosphoprotein 1 D28418 P0, 5′UTR (low match) Ribosomal protein 1 ribosomal protein L10 30 L25899 + + + + + + high in many libraries (RPL10) RIBOSOMAL PROTEIN 2 P53025 L10A (CSA-19) ribosomal protein L11 4 X79234 + + + + + + Alveolar (RPL11) rhabdomyosarcoma ribosomal protein L12 2 L06505 + + + + + + (RPL19) ribosomal protein L13 1 P26373 + + + + + + high in many libraries (PRL13) ribosomal protein L14 4 D87735 + + + + + + high in many libraries (RPL14) ribosomal protein L17 4 X53777 + blood only (RPL17) ribosomal protein L18 10 L11566 + + + + + (RPL18) ribosomal protein L18a 5 L05093 + + + + + High in fetal adrenal (RPL18A) gland and skin ribosomal protein L18a 2 X80821 + homologue ribosomal protein L19 15 X63527 + + + + + + (RPL19) ribosomal protein L21 6 U14967 + + + + + + (RPL21) ribosomal protein L22 3 D17652 + + + + + (RPL22) ribosomal protein L23 2 X55954 + + + + + + high in many libraries (RPL23) ribosomal protein L23a 5 U37230 + + + + + + high in many libraries (RPL23A) ribosomal protein L26 8 X69392 + + + + + + (RPL26) ribosomal protein L27 6 L05094 + + + + + (RPL27) ribosomal protein L27a 10 U14968 + + + + + + (RPL27A) ribosomal protein L28 6 U14969 + + + + + (RPL28) ribosomal protein L29 6 U10248 + + + + + + (RPL29) ribosomal protein L3 81 + + + + + + high in many libraries (RPL3) ribosomal protein L3 81 X06323 homologue ribosomal protein L30 6 X79238 + + + + + + high in lymphoma (RPL30) ribosomal protein L30 1 X79238 (RPL30) (low score) ribosomal protein L31 10 X15940 + + + + + + High in alveolar (RPL31) rhabdomyosarcoma ribosomal protein L32 3 X03342 + + + + + + (RPL32) ribosomal protein L33-like 1 AF047440 + + + + (RPL33L) ribosomal protein L34 5 L38941 + + + + + (RPL34) ribosomal protein L34 1 L38941 (RPL34) (low match) ribosomal protein L37 5 D23661 + + + + + + high in barstead (RPL37) prostate ribosomal protein L37a 4 X66699 + + + + + + high in many libraries ribosomal protein L38 1 Z26876 + + + + + + high in many libraries (PRL38) ribosomal protein L4 27 D23660 + + + + + + high in many libraries (RPL4) ribosomal protein L41 4 AF026844 + + + + + + high in many libraries (RPL41) ribosomal protein L5 14 U14966 + + + + + + High in alveolar (RPL5) rhabdomyosarcoma ribosomal protein L5 1 U14966 (RPL5) (low match) ribosomal protein L6 7 X69391 + + + + + + high in many libraries (RPL6) ribosomal protein L7 14 X52967 + + + + + + high in conorm (RPL7) ribosomal protein L7a 15 M36072 + + + + + + High in uterus, and (RPL7A) seminoma ribosomal protein L8 5 Z28407 + + + + + + high in ovary (RPL8) ribosomal protein L9 10 U09953 + + + + + (RPL9) ribosomal protein S10 5 U14972 + + + + + + high in many libraries (RPS10) ribosomal protein S11 4 X06617 + + + + + + high in many libraries (RPS11) ribosomal protein S11 1 AB007152 (RPS11) (low match) ribosomal protein S12 3 X53505 + + + + + + high in many libraries (RPS12) ribosomal protein S13 2 L01124 + + + + + (RPS13) ribosomal protein S14 12 M13934 + + + + + + (RPS14) ribosomal protein S15 2 M32405 + + + + + + (RPS15) ribosomal protein S16 3 M60854 + + + + + + High in prostate (RPS16) invasive tumor ribosomal protein S17 2 M13932 + + + + + + high in many libraries (RPS17) ribosomal protein S18 8 X69150 ribosomal protein S19 7 M81757 + + + + + + high in many libraries (RPS19) ribosomal protein S2 4 X17206 + + + + + + high in many libraries (RPS2) RIBOSOMAL PROTEIN S2 2 P15880 (RPS4) ribosomal protein S20 7 L06498 + + + + + + high in many libraries (RPS20) ribosomal protein S21 3 L04483 + + + + + + high in CD34+/CD38− (RPS21) hematopoietic cells and skin tumor ribosomal protein S23 3 D14530 + + + + (RPS23) ribosomal protein S24 7 M31520 + + + + + + high in uterus (RPS24) ribosomal protein S25 3 M64716 + + + + + + high in barstead (RPS25) prostate ribosomal protein S26 2 X69654 + + + + + (RPS26) ribosomal protein S27 5 U57847 + + + + + + ((metallopanstimulin 1) (RPS27) ribosomal protein S28 3 U58682 + + + + + (RPS28) ribosomal protein S29 2 U14973 + + + + + + (RPS29) ribosomal protein S3 9 X55715 + + + + + + high in many libraries (RPS3) ribosomal protein S3 1 U14990 (RPS3) (low match) ribosomal protein S3A 21 Z83334 + + + + + high in many libraries (RPS3A) ribosomal protein S3A 1 M77234 (RPS3A) (low score) ribosomal protein S4, X- 9 M58458 + + + + + high in ovary and linked (RPS4X) Synovial sarcoma ribosomal protein S4, Y- 2 M58459 + + + + + + linked (RPS4Y) ribosomal protein S5 4 U14970 + + + + + + high in lymphoma (RPS5) RIBOSOMAL PROTEIN S6 1 P10660 (PHOSPHOPROTEIN NP33) ribosomal protein S6 22 M20020 + + + + + + (RPS6) ribosomal protein S6 1 M77232 (RPS6) (non-exact 86%) ribosomal protein S6 3 L07597 + + + + + kinase, 90 kD, polypeptide 1 (RPS6KA1) ribosomal protein S6 1 X85106 kinase, 90 kD, polypeptide 2 (RPS6KA2) ribosomal protein S7 4 Z25749 + + + + + (RPS7) ribosomal protein S8 6 X67247 + + + + + (RPS8) ribosomal protein S9 8 U14971 colon tumor (RPS9) ribosomal protein, large, P0 18 M17885 T + + (RPLP0) ribosomal protein, large, P1 12 M17886 T + + + (RPLP1) ribosomal RNA 18S 11 X03205 (=M10098; K03432) (=polyadenylating sequence) ribosomal RNA 28S 2 M11167 ribosomal RNA, 16S 1 U25123 ring finger protein (non- 1 AJ001019 exact 58%) ring finger protein 3 (RNF3) 1 AJ001019 ring finger protein 4 (RNF4) 3 AB000468 + + + + ring zinc-finger protein 3 U41315 + + + + (ZNF127-Xp) RNA (guanine-7-) 1 AB007858 + + + + methyltransferase (RNMT) RNA binding motif protein 5 4 U23946 + + + + + (RBM5) RNA binding motif, single 1 D28483 + + + stranded interacting protein 2 (RBMS2) RNA helicase (putative), 1 X98743 + + + + + (Myc-regulated DEAD box protein) (MRD8) RNA helicase-related 1 AF083255 + + + + protein RNA pol II largest subunit 2 X74872 RNA polymerase I subunit 1 AF008442 + + + (RPA40) RTVP-1 protein 2 X91911 + + + + + S100 calcium-binding 2 M81457 + + + protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) (S100A10) S100 calcium-binding 1 X80201 + + + + protein A11 (calgizzarin) (S100A11) S100 calcium-binding 3 M80563 B + + protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)(S100A4) S100 calcium-binding 7 M21005 + + + high in bone marrow protein A8 (calgranulin A) (S100A8) S100 calcium-binding 14 X06233 + + high in invasive protein A9 (calgranulin B) larynx squamous cell (S100A9) carcinoma S164 gene 1 AF109907 S-adenosylmethionine 3 M88003 + + + + + decarboxylase 1 (AMD1) SB classII 5 M27487 + + + + + histocompatibility antigen alpha-chain SC35-interacting protein 1 5 AF030234 + + + + + + (SRRP129) scaffold attachment factor 1 U72355 + + + + + B (SAFB) scaffold attachment factor 1 U72355 B (SAFB) (non-exact 78%) scRNA molecule, 1 L13713 transcribed from Alu repeat SEC14 (S. cerevisiae)-like 4 D67029 + + + + (SEC14L) SEC23-like protein B 2 X97065 + + + + + (SEC23B) SEC63 (SEC63) 1 AF100141 + + + secreted protein, acidic, 7 M25746 + + + + + high in bone marrow cysteine-rich (osteonectin) stroma (SPARC) secretory carrier 1 AF038966 + + membrane protein 1 (SCAMP1) secretory carrier 1 AF005038 + + + + + + membrane protein 2 (SCAMP2) secretory carrier 1 AF005039 membrane protein 3 (SCAMP3) secretory granule 1 M33649 proteoglycan core (clones lambda-PG[6,7,8]) selectin L (lymphocyte 43 X17519 + + + adhesion molecule 1) (SELL) selectin P ligand (SELPLG) 13 U02297 + + sema domain, 2 U60800 + + + immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D) Ser/Arg-related nuclear 4 AF048977 + + + + + matrix protein (plenty of prolines 101-like) (SRM160) serine palmitoyltransferase 1 Y08685 + + + + subunit I (SPTI) serine palmitoyltransferase, 1 AB011098 + + + + + subunit II (LCB2) serine protease 1 J02907 serine protease inhibitor, 1 U78095 + + + + + Kunitz type, 2 (SPINT2) serine/threonine kinase 10 1 AB015718 + + + + + (STK10) serine/threonine kinase 19 1 L26260 + + + + (STK19) serine/threonine kinase 4 1 U18297 + + (STK4) serine/threonine protein 1 X66358 + + + + kinase KKIALRE (KKIALRE) serine/threonine protein- 1 Y10256 + + + kinase (NIK) SERINE/THREONINE- 1 P37023 PROTEIN KINASE RECEPTOR R3 PRECURSOR (SKR3) serologically defined colon 2 AF039694 cancer antigen 16 (NY-CO- 16) serologically defined colon 1 AF039698 B, T + + + cancer antigen 33 (SDCCAG33) serologically defined colon 1 AF039698 cancer antigen 33 (SDCCAG33) (low score) serologically defined colon 1 AF039698 cancer antigen 33 (SDCCAG33) (low score) serum deprivation 1 AF085481.1 response (phosphatidylserine-binding protein) (SDPR) (=S67386) serum/glucocorticoid 2 Y10032 + + + + + regulated kinase (SGK) SET domain, bifurcated 1 2 D31891 + + + + (SETDB1) SH2 domain protein 1A, 1 AF073019 T + Duncan's disease lymphoproliferative syndrome) (SH2D1A) SH3 binding protein (SAB) 2 AB005047 + + + + + SH3 domain protein 1B 4 U61167 + + + (SH3D1B) SH3BGR PROTEIN (=21- 1 P55822 GLUTAMIC ACID-RICH PROTEIN; 21-GARP) (non- exact 82% aa) SH3-binding domain 1 AF042081 + + + + + glutamic acid-rich protein like (SH3BGRL) SH3-domain GRB2-like 1 1 U65999 + + + + + (SH3GL1) SHC (Src homology 2 2 X68148 + + + + domain-containing) transforming protein 1 (SHC1) siah binding protein 1 2 U51586 + + + + (SiahBP1) siah binding protein 1 1 U51586 (SiahBP1) (non-exact, 69%) Sialomucin CD164 9 D14043 (CD164) sialophorin (gpL115, 2 J04536 leukosialin, CD43) (SNP) sialyltransferase (STHM) 1 U14550 + + + sialyltransferase 1 (beta- 2 X17247 + + + + + + galactoside alpha-2,6- sialytransferase) (SIAT1) sialyltransferase 4A (beta- 1 AF059321 B + + + + galactosidase alpha-2,3- sialytransferase) (SIAT4A) sialyltransferase 8 (alpha- 1 L41680 + 2,8-polysialytransferase) D (SIAT8D) signal peptidase 25 kDa 1 L38950 subunit signal recognition particle 1 X73459 + + + + + + 14 kD (homologous Alu RNA-binding protein) (SRP14) signal recognition particle 1 U51920 + + + 54 kD (SRP54) signal recognition particle 2 U20998 + + + + + 9 kD (SRP9) signal recognition particle 5 X06272 receptor (‘docking protein’) SRPR signal regulatory protein, 5 Y10376 + + beta, 1 (SIRP-BETA-1) signal sequence receptor, 2 Z12830 + + alpha (translocon- associated protein alpha) (SSR1) signal sequence receptor, 2 X74104 + + + + + beta (translocon- associated protein beta) (SSR2) signal transducer and 4 L41142 + + + + + + activator of transcription (STAT5A) signal transducer and 1 U18671 + activator of transcription 2, 113 KD (STAT2) signal transducer and 3 L29277 activator of transcription 3 (acute-phase response factor) (STAT3) signal transducer and 2 U48730 + + + + + + activator of transcription 5A (STAT5A) signal transducing adaptor 1 U43899 molecule (SH3 domain and ITAM motif) 1 (STAM) silencing mediator of 1 U37146 retinoid and thyroid hormone action (SMRT) similar to beta-transducin 1 U02609 + + + + superfamily proteins (SAZD) similar to S. cerevisiae 1 AB011169 + + + + SSM4 (TEB4) similar to yeast pre-mRNA 1 AF026031 + + + + + splicing factors, Prp1/Zer1 and Prp6 SIT protein 1 AJ010059.1 Sjogren syndrome antigen 2 M62800 + A1 (52 kD, ribonucleoprotein autoantigen SS-A/Ro) (SSA1) Sjogren syndrome antigen 1 M62800 A1 (52 kD, ribonucleoprotein autoantigen SS-A/Ro) (SSA1) (non-exact 63%) (match to zinc finger) SKAP55 homologue 1 AJ004886 + + + + (SKAP-HOM) skb1 (S. pombe) homolog 2 AF015913 + + + + + (SKB1) skeletal muscle abundant 1 X87613 + + + + + protein SMA3 (SMA3) 1 X83300 + + + + small acidic protein 3 U51678 + + + + + small EDRK-rich factor 2 2 Y10351 + + + + + + high in fetal lung (SERF2) small inducible cytokine A5 2 M21121 + + + + + + high in many libraries (RANTES) (SCYA5) small inducible cytokine 1 D63789 subfamily C, member 2 (SCYC2) small nuclear 2 M15841 + + + + ribonucleoprotein polypeptide B″ (SNRPB2) small nuclear 4 J04615 + + + + + + ribonucleoprotein polypeptide N (SNRPN) small nuclear 2 J04564 + + + + + ribonucleoprotein polypeptides B and B1 (SNRPB) small nuclear RNA 1 AF093593 + + + + + activating complex, polypeptide 5, 19 kD (SNAPC5) smallest subunit of 1 D55636 + + + + + + high in fetal lung ubiquinol-cytochrome c reductase SMC (mouse) homolog, X 1 L25270 + + + + + chromosome (SMCX) SMT3B protein (2) 2 X99585 + + + + + + SNARE protein (YKT6) (low 1 U95735 match) SNC19 1 U20428 SNC73 protein (SNC73) 2 J00220 + + + + + high in many libraries solute carrier family 1 2 U53347 + + + (neutral amino acid transporter), member 5 (SLC1A5) Solute carrier family 11 7 D50403 + (proton-coupled divalent metal ion transporters), member 1 (SLC11A1) solute carrier family 17 1 U90545 + (sodium phosphate), member 3 (SLC17A3) solute carrier family 19 1 U17566 B, + + (folate transporter), lymphoma member 1 (SLC19A1) solute carrier family 2 1 K03195 + + + + + + (facilitated glucose transporter), member 1 (SLC2A1) solute carrier family 23 3 D87075 + + + + (nucleobase transporters), member 2 (SLC23A2) solute carrier family 25 1 AF070548 B, T + + + + (mitochondrial carrier; oxoglutarate carrier), member 11 (SLC25A11) solute carrier family 31 3 U83461 + + (copper transporters), member 2 (SLC31A2) solute carrier family 4, 1 X62137 + + + anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) (SLC4A2) solute carrier family 4, 1 AB018282 + sodium bicarbonate cotransporter, member 8 (SLC4A8) solute carrier family 7 2 M80244 T, W + + + (cationic amino acid transporter, y+ system), member 5 (SLC7A5) solute carrier family 7 3 D87432 + + + + (cationic amino acid transporter, y+ system), member 6 (SLC7A6) solute carrier family 7 1 D87432 (cationic amino acid transporter, y+ system), member 6 (SLC7A6) (non- exact 77%) solute carrier family 9 1 AF030409 + + + + (sodium/hydrogen exchanger), isoform 6 (SLC9A6) somatic cytochrome c 2 M22877 (HCS) SON DNA binding protein 2 X63753 + + + + (SON) son of sevenless 1 L13858 + + + (Drosophila) homolog 1 (SOS1) sorcin (SRI) 1 M32886 sortilin 1 (SORT1) 2 X98248 + + + sortilin-related receptor, 6 Y08110 L(DLR class) A repeats- containing (SORL1) sorting nexin 1 (SNX1) 3 U53225 + + + + + sorting nexin 2 (SNX2) 2 AF043453 sorting nexin 6 (SNX6) 1 AF121856.1 (=U83194.1 TRAF4- associated factor 2) Sp3 transcription factor 1 X68560 + + + + + (SP3) Sp3 transcription factor 4 M97191 + + + + + (SP3) special AT-rich sequence 1 M97287 binding protein 1 (binds to nuclear matrix/scaffold- associating DNA's) (SATB1) speckle-type POZ protein 4 AJ000644 (SPOP) speckle-type POZ protein 1 AJ000644 (SPOP) (non-exact) spectrin SH3 domain 6 U87166 + + + + binding protein 1 (SSH3BP1) Spectrin, alpha, non- 2 J05243 + + + erythrocytic 1 (alpha-fodrin) (SPTAN1) spermidine/spermine N1- 11 M55580 acetyltransferase (SAT) spermidine/spermine N1- 1 U40369 acetyltransferase (SAT) (non-exact, 84%) spermine synthase (SMS) 1 AD001528 + + + + + SPF31 (SPF31) 1 AF083190 + + + + + sphingomyelin 1 X52679 + + + phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) (SMPD1) SPINDLIN HOMOLOG 1 Q99865 (PROTEIN DXF34) spinocerebellar ataxia 1 3 X79204 B + + (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1) (SCA1) spinocerebellar ataxia 2 1 U70323 B + (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2) (SCA2) spinocerebellar ataxia 7 2 AJ000517 + (olivopontocerebellar atrophy with retinal degeneration) (SCA7) spliceosome associated 3 U41371 + + + + + protein (SAP 145) splicing factor (CC1.3) 2 L10910 + + + + + + (CC1.3) splicing factor SRp40-1 7 U30826 + + + + + + (SRp40) splicing factor, 3 M74002 B + + + + arginine/serine-rich 11 (SFRS11) splicing factor, 4 L41887 + + + + arginine/serine-rich 7 (35 kD) (SFRS7) Src-like adapter protein 1 U30473 (non-exact, 76% aa) Src-like-adapter (SLA) 6 D89077 + + + + Src-like-adapter (SLA) (low 1 D89077 match) Src-like-adapter (SLA) (low 1 U44403 score) stannin (SNN) 2 AF030196 + + + + + STAT induced STAT 1 AB004904 + inhibitor 3 (SSI-3) STE20-like kinase 3 (MST- 2 AF024636 + + + + + 3) step II splicing factor SLU7 1 AF101074 + + + + (SLU7) steroid sulfatase 1 M17591 steroid sulfatase 1 J04964 + + + (microsomal), arylsulfatase C, isozyme S (STS) sterol carrier protein 2 1 M55421 + + + + + (SCP2) sterol O-acyltransferase 1 AF059202 + (acyl-Coenzyme A: cholesterol acyltransferase) 1 (SOAT1) stimulated trans-acting 6 X82200 + + + factor (50 kDa) (STAF50) Striatin, calmodulin-binding 1 U17989 protein (STRN) (low match, 71% aa) Stromal antigen 2 (STAG2) 2 Z75331 + + + + stromal interaction 3 U52426 + + + + + molecule 1 (STIM1) structure specific 1 M86737 + + + + recognition protein 1 (SSRP1) succinate dehydrogenase 5 L21936 + complex, subunit A, flavoprotein (Fp) (SDHA) succinate dehydrogenase 1 U17248 + + + + + complex, subunit B, iron sulfur (Ip) (SDHB) succinate dehydrogenase 1 U57877 + + + + + complex, subunit C, integral membrane protein, 15 kD (SDHC) succinate dehydrogenase 3 AB006202 + + + complex, subunit D, Integral membrane protein (SDHD) succinate-CoA ligase, 1 AF058954 + + + + + GDP-forming, beta subunit (SUCLG2) succinyl CoA synthetase 1 Z68204 sudD (suppressor of 2 AF013591 + + + bimD6, Aspergillus nidulans) homolog (SUDD) sulfotransferase family 1A, 1 L19999 + + + phenol-preferring, member 1 (SULT1A1) sulfotransferase family 1A, 1 U37686 phenol-preferring, member 3 (SULT1A3) (non-exact 67%) superoxide dismutase 1, 4 X02317 + + + + soluble (amyotrophic lateral sclerosis 1 (adult)) (SOD1) superoxide dismutase 2, 5 Y00985 + + + + + mitochondrial (SOD2) supervillin (SVIL) 2 AF051851 + + + suppression of 2 U15131 + + + tumorigenicity 5 (ST5) suppression of 1 U15779 tumorigenicity 5 (ST5) (non-exact 82%) suppressor of K+ transport 1 AF038960 + + defect 1 (SKD1) suppressor of Ty 1 AF064804 + + + + + (S. cerevisiae) 3 homolog (SUPT3H) suppressor of Ty 2 U38817 + + + + + (S. cerevisiae) 4 homolog 1 (SUPT4H1) suppressor of Ty 2 U56402 + + (S. cerevisiae) 5 homolog (SUPT5H) suppressor of Ty 2 U46691 + + + + + + (S. cerevisiae) 6 homolog (SUPT6H) suppressor of variegation 1 AF019968 + + + 3-9 (Drosophila) homolog 1 (SUV39H1) survival of motor neuron 1, 1 U18423 telomeric (SMN1) SWI/SNF related, matrix 1 M88163 + + + associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1) (non-exact, 75%) SWI/SNF related, matrix 2 D26155 + associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2) SWI/SNF related, matrix 1 D26156 + + + + + + associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4) SWI/SNF related, matrix 4 U66616 + + + + + + associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2) SWI/SNF related, matrix 2 AF035262 B, W + + + + associated, actin dependent regulator of chromatin, subfamily e, member 1 (SMARCE1) synaptobrevin-like 1 1 X95803 + + + + (SYBL1) synaptosomal-associated 2 AJ011915 + + + + protein, 23 kD (SNAP23) syndecan binding protein 15 AF006636 + + + + + (syntenin) (SDCBP) synovial sarcoma, 2 X79201 + translocated to X chromosome (SSXT) syntaxin 16 1 AF038897 syntaxin 3A (STX3A) 2 U32315 + + + syntaxin 6 (STX6) 1 AJ002078.1 SYNTAXIN BINDING 1 O00186 PROTEIN 3 (UNC-18 HOMOLOG 3) (UNC-18C) syntaxin-16C 1 AF008937 SYT interacting protein 1 AF080561 + + + + (SIP) T cell activation, increased 4 M88282 + late expression (TACTILE) T cell receptor V alpha 2 X58744 gene segment V-alpha-7 (clone IGRa11) T cell receptor V alpha 1 X58740 gene segment V-alpha-w27 T3 receptor-associating 5 S83390 + + + + + + cofactor-1 tafazzin (cardiomyopathy, 1 X92763 + + + + dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) (TAZ) TAFII100 protein (non- 1 U80191 exact 53%) tankyrase, TRF1- 1 AF082556 + + + + interacting ankyrin-related ADP-ribose polymerase (TNKS) TAP1, TAP2, LMP2, LMP7 1 X66401 and DOB TAR DNA-binding protein- 6 U23731 + + + + + 43 Tat interactive protein 2 U40989 + + + + + (60 kD) (TIP60) TATA box binding protein 1 O00268 (TBP)-associated factor, RNA polymerase II, C1, 130 kD (TAF2C1) (non- exact, 55%) TATA box binding protein 4 X97999 + + + + + (TBP)-associated factor, RNA polymerase II, F, 55 kD (TAF2F) TATA box binding protein 2 U21858 + + + + + (TBP)-associated factor, RNA polymerase II, G, 32 kD (TAF2G) TATA box binding protein 1 D63705 + + + + + (TBP)-associated factor, RNA polymerase II, I, 28 kD (TAF2I) Tax1 (human T-cell 1 U33821 + + + + + leukemia virus type I) binding protein 1 (TAX1BP1) T-box 2 (TBX2) (non-exact 1 U28049 + + + 77%) TBP-associated factor 172 1 AJ001017 + + + (TAF-172) T-cell death-associated 1 U95218 + gene 8 (TDAG8) T-cell leukemia/lymphoma 1 X82240 + 1A (TCL1A) T-cell leukemia/lymphoma 1 X82240 1A (TCL1A) (low match) T-cell receptor (delta D2- 1 M22197 J1-region) (clone K3B) T-cell receptor (V beta 5.1, 1 M97705 J beta 1.5, C beta 1) (low match) T-cell receptor alpha delta 2 AE000662 (=M94081) T-cell receptor alpha 1 B39625 enhancer-binding protein, short form (=X58636 Mouse LEF1 lymphoid enhancer binding factor 1 (=D16503)) T-cell receptor delta gene 1 M22197 D2-J1-region, clone K3B T-cell receptor germline 1 M11955 beta chain gene V-region (V) V-beta-MT1-1 T-cell receptor germline 1 M14159 + only in blood beta-chain gene J2.1 exon T-cell receptor germline 2 M22152 delta-chain D-J region T-cell receptor interacting 2 AJ224878 + molecule (TRIM) protein T-cell receptor rearranged 1 M21784 delta-chain, V-region (V- delta 3-J) T-cell receptor, alpha 3 AE000660 + + + + + (V, D, J, C) (TCRA) T-cell receptor, beta cluster 3 L34740 + + + + + + high in pancreas (TCRB) T-cell receptor, delta 2 X73617 + + + (V, D, J, C) (TCRD) T-cell, immune regulator 1 3 U45285 only found in tumor (TCIRG1) TCF-1 mRNA for T cell 1 X59870 factor 1 TCF-1 mRNA for T cell 1 X59870 factor 1 (splice form B) (low match) T-COMPLEX PROTEIN 1, 1 Q99832 ETA SUBUNIT (TCP-1- ETA) (CCT-ETA) (HIV-1 NEF INTERACTING PROTEIN) T-COMPLEX PROTEIN 1, 1 P50990 THETA SUBUNIT (TCP-1- THETA) (CCT-THETA) (KIAA0002) TCR eta = T cell 1 S94421 receptor(eta-exon) TCR V Beta 13.2 1 X75419 TERA 1 AC004472 testis enhanced gene 33 X75861 + + + + + + transcript (TEGT) tetracycline transporter-like 2 L11669 + + + + protein (TETRAN) tetratricopeptide repeat 1 U46570 + + + + + domain 1 (TTC1) tetratricopeptide repeat 1 U46571 + + + domain 2 (TTC2) tetratricopeptide repeat 1 D84296 + + + + + domain 3 (TTC3) TGFB1-induced anti- 1 D86970 + + + + + apoptotic factor 1 (TIAF1) thioredoxin reductase 1 3 S79851 + + + + (TXNRD1) THIOREDOXIN- 1 P30048 DEPENDENT PEROXIDE REDUCTASE PRECURSOR, mitochondrial (ANTI- OXIDANT PROTEIN 1) (AOP-1) threonyl-tRNA synthetase 1 M63180 + + + + (TARS) thrombin inhibitor 1 Z22658 thrombospondin 1 (THBS1) 2 X04665 + + + + + thromboxane A synthase 1 1 M80647 + + + + (platelet, cytochrome P450, subfamily V) (TBXAZ1) thymidine kinase 2, 2 X76104 + + + mitochondrial (TK2) thymidylate kinase (CDC8) 1 L16991 + + + + thymine-DNA glycosylase 2 U51166 + + + + + (TDG) Thymosin, beta 10 2 M20259 + + + + + + (TMSB10) thymosin, beta 4, X 29 M17733 + + + + chromosome (TMSB4X) thyroid autoantigen 70 kD 7 J04611 (Ku antigen) (G22P1) thyroid hormone receptor 1 AF016270 + + + coactivating protein (SMAP) thyroid hormone receptor 2 L40357 + + + + interactor 7 (TRIP7) thyroid hormone receptor 4 L40411 + interactor 8r (TRIP8) thyroid hormone receptor- 1 D83783 associated protein, 230 kDa subunit (TRAP230) thyroid receptor interacting 2 L40388 + + + + protein 15 (TRIP15) TI-227H 1 D50525 TIA1 cytotoxic granule- 1 M77142 + + + + associated RNA-binding protein (TIA1) tissue inhibitor of 1 X02598 + + + + + + metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) (TIMP1) tissue inhibitor of 1 M32304 + + + + + high in placenta metalloproteinase 2 (TIMP2) tissue specific 1 U58766 + + + + + transplantation antigen P35B (TSTA3) titin (TTN) 1 X64697 + + + + + high in muscle TNF receptor-associated 1 U12597 + + + + factor 2 (TRAF2) TNF receptor-associated 1 AF110908.1 + factor 3 (TRAF3) TNF receptor-associated 1 U78798 factor 6 (TRAF6) (low match) toll-like receptor 1 (TLR1) 1 U88540 + toll-like receptor 2 (TLR2) 1 U88878 + + + + toll-like receptor 4 (TLR4) 1 U88880 + + toll-like receptor 5 (TILR5) 1 AF051151 + + topoisomerase (DNA) I 1 J03250 + + + (TOP1) topoisomerase (DNA) II 2 X68060 + + + + + beta (180 kD) (TOP2B) topoisomerase (DNA) III 3 D87012 + beta (TOP3B) TR3beta 1 D85245 + TRAF family member- 3 U63830 + + + + + + associated NF-kB activator (TANK) TRANSALDOLASE 1 P37837 transaldolase 1 (TALDO1) 4 L19437 + + + + + transaldolase-related 1 AF010398 protein transcobalamin II (TCII) 1 AF047576 transcription elongation 2 Z47087 + + + + + factor B (SIII), polypeptide 1-like (TCEB1L) transcription elongation 1 L47345 + + + + + + factor B (SIII), polypeptide 3 (110 kD, elongin A) (TCEB3) transcription factor 12 1 M83233 + + + + + (HTF4, helix-loop-helix transcription factors 4) (TCF12) transcription factor 17 2 D89928 + + (TCF17) transcription factor 4 2 X52079 + + + + (TCR4) transcription factor 6-like 1 2 M62810 + + + + (mitochondrial transcription factor 1-like) (TCF6L1) transcription factor 7-like 2 1 Y11306 + + + + (T-cell specific, HMG-box) (TCF7L2) transcription factor binding 1 X96717 + + + + + to IGHM enhancer 3 (TFE3 transcription factor IL-4 7 AF067575 + + + + + + Stat transcription factor IL-4 1 U16031 Stat (low match) transcription factor ISGF-3 4 M97935 (=M97936) transcription factor REST 1 A56138 transcription factor TFIID 1 Z22828 transcriptional adaptor 2 1 AF064094 (ADA2, yeast, homolog)- like (TADA2L) transcriptional intermediary 1 AF009353 factor 1 (TIF1) (non-exact 72%) transducin (beta)-like 1 1 Y12781 + + + + + (TBL1) transducin-like enhancer of 1 M99438 + + split 3, homolog of Drosophila E(sp1) (TLE3) Transformation/transcription 1 AF076974 + + + + + domain-associated protein (TRRAP) transformation-sensitive, 2 M86752 + + + + similar to Saccharomyces cerevisiae STI1 (STI1L) transforming growth factor 1 AB009356 beta-activated kinase 1 (TAK1) (non-exact 78%) transforming growth factor 3 AJ222700 + + + + + beta-stimulated protein TSC-22 (TSC22) transforming growth factor, 1 L07594 + + + + beta receptor III (betaglycan, 300 kD) (TGFBR3) transforming growth factor, 2 4507466 + + + + + + beta-induced, 68 kD (TGFBI) TRANSFORMING 2 Q15582 GROWTH FACTOR-BETA INDUCED PROTEIN IG-H3 PRECURSOR (BETA IG- H3) transforming, acidic coiled- 1 AF049910 coil containing protein 1 (TACC1) (non-exact 70%) transgelin 2 (TAGLN2) 14 D21261 + + + + + + transgelin 2 (TAGLN2) 1 D21261 (non-exact) trans-Golgi network protein 2 AF029316 + + (46, 48, 51 kD isoforms) (TGN51) transient receptor potential 1 X89066 + + + + channel 1 (TRPC1) transketolase (Wernicke- 7 L12711 + + + + Korsakoff syndrome) (TKT) translation factor sui1 1 AF064607 + + + + + homolog (GC20) translin (TSN) 3 X78627 + + + + + translin-associated factor X 1 X95073 + + + + (TSNAX) transmembrane 1 U79725 glycoprotein (A33) transmembrane protein 1 X69910 + + + + + (63 kD), endoplasmic reticulum/Golgi intermediate compartment (P63) transmembrane protein 1 1 AB001523 + + + (TMEM2) TRANSMEMBRANE 1 P51805 PROTEIN SEX PRECURSOR (non-exact 65%) transmembrane trafficking 2 X97442 + + + + + + protein (TMP21) transporter 1, ABC (ATP 3 L21208 + + + + + binding cassette) (TAP1) Treacher Collins- 2 U40847 + + + + + high in many libraries Franceschetti syndrome 1 (TCOF1) triosephosphate isomerase 2 X69723 + + + + + + 1 (TPI1) tropomyosin 2 X04201 + + + + tropomyosin 4 (TPM4) 2 X05276 + + + + + TRPM-2 protein 2 M63376 tryptase I precursor (non- 1 A35863 exact 64%)(=P20231) tryptophan rich basic 1 Y12478 protein (WRB) tryptophanyl-tRNA 1 X59892 + + + + + + synthetase (WARS) Ts translation elongation 1 L37936 + + + + factor, mitochondrial (TSFM) ttopoisomerase (DNA) II 1 Z15115 + + + beta (180 kD) Tu translation elongation 4 L38995 factor, mitochondrial (TUFM) tuberous sclerosis 1 1 AF013168 + + + + (TSC1) tuberous sclerosis 2 1 X75621 + + + + (TSC2) tubulin, alpha 1 (testis 1 X06956 + + specific) (TUBA1) tubulin, alpha, ubiquitous 11 K00558 + + + + + + high in many libraries (K-ALPHA-1) tubulin, alpha, ubiquitous 1 K00558 (K-ALPHA-1) (low match) tubulin-specific chaperone 1 U61234 + + + + c (TBCC) tumor necrosis factor 7 U37518 + + + + (ligand) superfamily, member 10 (TNFSF10) tumor necrosis factor 1 AF046888 + + + + (ligand) superfamily, member 13 (TNFSF13) tumor necrosis factor 1 AF036581 (ligand) superfamily, member 14 (TNFSF14) tumor necrosis factor 1 D38122 + Found only in library (ligand) superfamily, 386: T-cell lymphoma member 6 (TNFSF6) tumor necrosis factor 1 L09753 B only (ligand) superfamily, member 8 (TNFSF8) tumor necrosis factor 1 AF061034 + + + + alpha-inducible cellular protein containing leucine zipper domains (FIP2) Tumor necrosis factor 2 M63928 + + receptor superfamily member 7 (TNFRSF7) tumor necrosis factor 1 AF016266 + + + + + receptor superfamily, member 10b (TNFRSF10B) tumor necrosis factor 3 AF012629 + receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C) tumor necrosis factor 1 AF023849 found only in prostate receptor superfamily, member 10d, decoy with truncated death domain (TNFRSF10D) (non-exact 84%) tumor necrosis factor 1 U94508 + + + + + receptor superfamily, member 12 (translocating chain-association membrane protein) (TNFRSF12) tumor necrosis factor 1 U70321 + + + + + receptor superfamily, member 14 (herpesvirus entry mediator) (TNFRSF14) tumor necrosis factor 5 U52165 + + + + + receptor superfamily, member 1B (TNFRSF1B) tumor necrosis factor 1 X63717 B, W + receptor superfamily, member 6 (TNFRSF6) tumor necrosis factor 1 M63928 + + receptor superfamily, member 7 (TNFRSF7) tumor necrosis factor, 8 M92357 + + + alpha-induced protein 2 (TNFAIP2) tumor necrosis factor, 2 M59465 alpha-induced protein 3 (TNFAIP3) tumor protein 53-binding 1 AF078776 + + + + protein, 1 (TP53BP1) tumor protein p53 (Li- 1 M14695 + + + Fraumeni syndrome) (TP53) Tumor protein p53-binding 1 U82939 + + + protein (TP53BPL) tumor protein, 35 X16064 translationally-controlled 1 (TPT1) tumor protein, 1 X16064 translationally-controlled 1 (TPT1) (low score) tumor rejection antigen 9 X15187 + + + + + + (gp96) 1 (TRA1) tumorous imaginal discs 2 AF061749 + (Drosophila) homolog (TID1) TXK tyrosine kinase (TXK) 2 L27071 type II integral membrane 1 AJ001685 + found only in fetal protein (NKG2-E) liver/spleen TYRO protein tyrosine 3 AF019562 + kinase binding protein (TYROBP) tyrosine 3- 1 X57346 + + + + + high in ecnorm monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) tyrosine 3- 1 M86400 monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (YWHAZ) tyrosine 3- 1 M86400 monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (YWHAZ) Tyrosine kinase 2 (TYK2) 3 X54637 + + + + TYROSINE-PROTEIN 2 P43403 KINASE ZAP-70 (70 KD ZETA-ASSOCIATED PROTEIN) (SYK-RELATED TYROSINE KINASE) tyrosyl-tRNA synthetase 1 U89436 + + + + + (YARS) U1 small nuclear RNA 1 M14387 U19H snoRNA (=M63485 1 AJ224166 R. norvegicus matrin 3) U2(RNU2) small nuclear 1 M96982 + + + + RNA auxillary factor 1 (non- standard symbol) (U2AF1) U22 snoRNA host gene 2 U40580 (UHG) U4/U6-associated RNA 4 AF016370 + + + + splicing factor (HPRP3P) U49 small nuclear RNA 1 X96649 U5 snRNP-specific protein 1 AB007510 + + + + + (220 kD), ortholog of S. cerevisiae Prp8p (PRP8) U5 snRNP-specific protein, 4 D21163 + + + + + 116 kD (U5-116 KD) U5 snRNP-specific protein, 3 Z70200 200 kDa (DEXH RNA helicase family) (U5-200-KD) Uba80 mRNA for ubiquitin 4 S79522 + + + + + + high in ovary ubiquinol-cytochrome c 1 D55636 + + + + + + high in fetal lung reductase (6.4 kD) subunit (UQCR) UBIQUINOL- 1 P47985 CYTOCHROME C REDUCTASE IRON- SULFUR SUBUNIT PRECURSOR (RIESKE IRON-SULFUR PROTEIN) (RISP) (low match) ubiquitin A-52 residue 2 X56999 ribosomal protein fusion product 1 (UBA52) ubiquitin activating enzyme 1 AF094516 + + + E1-like protein (GSA7) ubiquitin C (UBC) 5 AB009010 + + + + + high in ovary ubiquitin carboxyl-terminal 1 M30496 + + + + + esterase L3 (ubiquitin thiolesterase) (UCHL3) ubiquitin fusion degradation 1 U64444 + + + + + 1-like (UFD1L) ubiquitin protein ligase E3A 1 U84404 B + + + (human papilloma virus E6- associated protein, Angelman syndrome) (UBE3A) ubiquitin specific protease 4 D80012 + + + + + 10 (USP10) ubiquitin specific protease 1 U44839 + + + + + + 11 (USP11) ubiquitin specific protease 3 AB011101 + + + + + 15 (USP15) ubiquitin specific protease 1 AB020698 + 19 (USP19) ubiquitin specific protease 1 AF017305 B + + + + 4 (proto-oncogene) (USP4) ubiquitin specific protease 1 AF017306 4 (proto-oncogene) (USP4) (non-exact, 66%) ubiquitin specific protease 1 Z72499 + + + + 7 (herpes virus-associated) (USP7) ubiquitin specific protease 5 D29956 + + + + 8 (USP8) UBIQUITIN-ACTIVATING 1 P22314 ENZYME E1 (A1S9 PROTEIN) (56%) ubiquitin-activating enzyme 1 M58028 + + + + + E1 (A1S9T and BN75 temperature sensitivity complementing) (UBE1) ubiquitin-activating enzyme 1 L34170 + + + + E1, like (UBE1L) UBIQUITIN-BINDING 1 U41806 + + PROTEIN P62; phosphotyrosine independent ligand for the Lck SH2 domain p62 (P62) ubiquitin-conjugating 2 U49278 + + + + + + enzyme E2 variant 1 (UBE2V1) ubiquitin-conjugating 1 X98091 enzyme E2 variant 2 (UBE2V2) UBIQUITIN- 1 Q16781 CONJUGATING ENZYME E2-17 KD (UBIQUITIN- PROTEIN LIGASE) ubiquitin-conjugating 1 M74525 + + + + + enzyme E2B (RAD6 homolog) (UBE2B) ubiquitin-conjugating 1 AF032456 + + + + + enzyme E2G 2 (homologous to yeast UBC7) (UBE2G2) ubiquitin-conjugating 1 Z29328 + + + + + enzyme E2H (homologous to yeast UBC8) (UBE2H) ubiquitin-conjugating 1 X92962 + + + enzyme E2L 1 (UBE2L1) ubiquitin-conjugating 3 AJ000519 + + + + enzyme E2L 3 (UBE2L3) ubiquitin-conjugating 4 AF031141 + + + + + enzyme E2L 6 (UBE2L6) ubiquitin-like 1 (sentrin) 2 U61397 + + + + + (UBL1) UDP-N-acetyl-alpha-D- 2 X85019 galactosamine:polypeptide N- acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2) UDP-N-acetyl-alpha-D- 1 X92689 galactosamine:polypeptide N- acetylgalactosaminyltransferase 3 (GalNAc-T3) (GALNT3) (non-exact 65%) unactive progesterone 2 L24804 + + + + receptor, 23 Kd (P23) unconventional myosin-ID 3 U57053 (MYO1F) uncoupling protein 1 U94592 homolog (UCPH) uncoupling protein 1 U94592 homolog (UCPH) (low match 67%) Unknown gene product 1 AC002310 unknown mRNA (clone 1 AF070542 24514) unknown protein (clone 2 Z70223 ICRFp507L0677) unknown protein 1 AF070626 + + + + + + (Hs.93832) unknown protein IT14 1 AF040966 uppressor of Ty 1 D79984 + + + + + + (S. cerevisiae) 6 homolog upregulated by 1,25- 74 S73591 + + + + + high in heart dihydroxyvitamin D-3 (VDUP1) upregulated by 1,25- 1 S73591 dihydroxyvitamin D-3 (VDUP1) (low match) upregulated by 1,25- 1 S73591 dihydroxyvitamin D-3 (VDUP1) (low match) upregulated by 1,25- 1 S73591 dihydroxyvitamin D-3 (VDUP1) (low score) upstream binding factor 1 X53461 + + + + (hUBF) UV radiation resistance 2 X99050 + + + + associated gene (UVRAG) vacuolar proton-ATPase, 4 X71490 + + + + + subunit D; V-ATPase, subunit D (ATP6DV) v-akt murine thymoma viral 1 M63167 + + + + + oncogene homolog 1 (AKT1) Vanin 2 (VNN2) 3 AJ132100 vasodilator-stimulated 3 Z46389 + + + + phosphoprotein (VASP) vav 1 oncogene (VAV1) 1 M59834 + vav 2 oncogene (VAV2) 1 S76992 + + v-crk avian sarcoma virus 1 D10656 W + + + CT10 oncogene homolog (CRK) v-erb-b2 avian 1 M29366 + erythroblastic leukemia viral oncogene homolog 3 (ERBB3) VERSICAN CORE 1 P13611 PROTEIN PRECURSOR Vesicle-associated 1 M36196 + + + + membrane protein 1 (synaptobrevin 1) (VAMP1) vesicle-associated 1 U64520 membrane protein 3 (cellubrevin) (VAMP3) v-fos FBJ murine 26 K00650 + + + + + high in aorta osteosarcoma viral oncogene homolog (FOS) v-fos FBJ murine 1 K00650 osteosarcoma viral oncogene homolog (FOS) (low match) villin 2 (ezrin) (VIL2) 1 X51521 + + + + + villin-like protein 1 D88154 vimentin (VIM) 12 X56134 + + + + + high in many libraries vinculin (VCL) 4 M33308 + + + + vitamin A responsive; 6 AF070523 + + + + cytoskeleton related (JWA) v-jun avian sarcoma virus 2 U65928 + + + + + 17 oncogene homolog (JUN) v-myb avian myeloblastosis 1 M15024 + + viral oncogene homolog (MYB) voltage-dependent anion 1 L06132 + + + + + channel 1 (VDAC1) voltage-dependent anion 4 U90943 + + + + channel 3 (VDAC3) von Hippel-Lindau 1 L15409 + + + + syndrome (VHL) von Willebrand factor 1 X06828 (vWF) (low matched) v-raf murine sarcoma 3611 2 L24038 + + + + viral oncogene homolog 1 (ARAF1) v-raf-1 murine leukemia 1 X03484 + + + + + viral oncogene homolog 1 (RAF1) v-ral simian leukemia viral 3 M35416 oncogene homolog B (ras related; GTP binding protein) (RALB) V-rel avian 1 L19067 + + + + reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)) (RELA) v-yes-1 Yamaguchi 2 M16038 + + + + sarcoma viral related oncogene homolog (LYN) WD repeat domain 1 1 AB010427 + + + + + + (WDR1) WDR1 (=AF020260) 1 AF020056 WD-repeat protein 2 U94747 + + + (HAN11) Williams-Beuren syndrome 12 AF045555 + + + + + + chromosome region 1 (WBSCR1) Wiskott-Aldrich syndrome 4 X86019 + + + + protein interacting protein (WASPIP) X (inactive)-specific 2 M97168 transcript (XIST) xeroderma pigmentosum, 3 D21089 + + + + complementation group C (XPC) XIAP associated factor-1 2 X99699 + XIB 1 X90392 + + + + X-linked anhidroitic 1 AF003528 ectodermal dysplasia X-ray repair 1 M30938 + + + + + high in spleen complementing defective repair in Chinese hamster cells 5 (double-strand- break rejoining; Ku autoantigen, 80 kD) (XRCC5) XRP2 protein 1 AJ007590 yeloid differentiation 1 U84408 + + + + primary response gene (88) (MYD88) zeta-chain (TCR) 1 L05148 + + associated protein kinase (70 kD) (ZAP70) zeta-chain (TCR) 1 L05148 associated protein kinase (70 kD) (ZAP70) (low match) zinc finger protein 2 U69274 + + + + + (Hs.47371) zinc finger protein 1 U69645 + + + + + (Hs.78765) zinc finger protein 10 (KOX1) 1 X78933 + (ZNF10) only ZINC FINGER PROTEIN 1 Q15973 124 (HZF-16) (non-exact 51%) zinc finger protein 124 1 S54641 (HZF-16) (ZNF124) (non- exact, 78%) ZINC FINGER PROTEIN 1 P52736 133 zinc finger protein 136 1 U09367 + + (clone pHZ-20) (ZNF136) zinc finger protein 140 1 U09368 + + + (clone pHZ-39) (ZNF140) zinc finger protein 140 1 AF060865 (clone pHZ-39) (ZNF140) (non-exact 59%) zinc finger protein 140 1 U09368 (clone pHZ-39) (ZNF140) (non-exact 73%) zinc finger protein 140 1 S66508 (clone pHZ-39) (ZNF140) (non-exact 73% aa) zinc finger protein 140 1 U09368 (clone pHZ-39) (ZNF140) (non-exact, 80%) zinc finger protein 143 2 U09850 + + + + + + (clone pHZ-1) (ZNF143) zinc finger protein 143 1 U09850 (clone pHZ-1) (ZNF143) (low match) zinc finger protein 148 1 AF039019 + (pHZ-52) (ZNF148) ZINC FINGER PROTEIN 1 Q13105 151 (MIZ-1 PROTEIN) (low match) zinc finger protein 173 1 U09825 B, T + + + (ZNF173) zinc finger protein 192 1 U57796 (ZNF192) (non-exact, 66%) zinc finger protein 198 1 AJ224901 + + + (ZNF198) zinc finger protein 2 (ZNF2) 1 X60152 (low match) zinc finger protein 200 1 AF060866 + + (ZNF200) zinc finger protein 207 6 AF046001 + + + + + + high in prostate (ZNF207) zinc finger protein 216 2 AF062072 + + + + + (ZNF216) zinc finger protein 217 1 AF041259 T activated + (ZNF217) ZINC FINGER PROTEIN 1 P17026 22 (ZINC FINGER PROTEIN KOX15) (non- exact 58%) zinc finger protein 230 1 U95044 + (ZNF230) Zinc finger protein 239 1 L26914 + + (ANF239) zinc finger protein 261 1 AB002383 + + + + (ZNF261) zinc finger protein 262 1 AB007885 + + + + (ANF262) zinc finger protein 263 1 D88827 (ZNF263) zinc finger protein 264 1 AB007872 + + + (ZNF264) ZINC FINGER PROTEIN 1 Q06730 33A (ZINC FINGER PROTEIN KOX31) (KIAA0065) (HA0946) zinc finger protein 42 1 M58297 + + + + + (myeloid-specific retinoic cid-responsive) (ZNF42) zinc finger protein 43 1 X59244 (HTF6) (ZNF43) (low match) zinc finger protein 43 1 X59244 (HTF6) (ZNF43) (non- exact, 54%) zinc finger protein 43 1 X59244 (HTF6) (ZNF43) (non- exact, 71%) ZINC FINGER PROTEIN 1 P28160 43 (ZINC PROTEIN HTF6) (non-exact 67%) zinc finger protein 45 (a 1 L75847 only found in testis Kruppel-associated box (KRAB) domain polypeptide) (ZNF45) ZINC FINGER PROTEIN 1 P24278 46 (ZINC FINGER PROTEIN KUP) (non-exact 62%) zinc finger protein 6 1 X56465 + + + + (CMPX1) (ZNF6) zinc finger protein 74 1 X71623 (Cos52) (ZNF74) (non- exact, 67%) zinc finger protein 76 1 M91592 + + + + (expressed in testis) (ZNF76) ZINC FINGER PROTEIN 1 P51522 83 (ZINC FINGER PROTEIN HPF1) (non- exact 65%) zinc finger protein 84 1 M27878 T activated + + + (HPF2) (ZNF84) zinc finger protein 85 2 U35376 + + + (ZNF85)) zinc finger protein 9 (ZNF9) 5 M28372 + + + + + ZINC FINGER PROTEIN 1 P35789 93 (=ZINC FINGER PROTEIN HTF34) (non- exact 70%) zinc finger protein C2H2-25 3 U38904 + + + (ZNF25) zinc finger protein clone 1 AF024706 L3-4 zinc finger protein 4 M92843 + blood only homologous to Zfp-36 in mouse (ZFP36) ZINC FINGER PROTEIN 1 Q03164 HRX (ALL-1) (71% a.a.) zinc finger protein HZF4 1 X78927 zinc finger protein RIZ 1 D45132 + + + + + zinc finger protein, 1 U40462 + subfamily 1A, 1 (Ikaros) (LYF1) zinc finger protein, 1 U40462 subfamily 1A, 1 (Ikaros) (LYF1) (low match) zinc finger transcriptional 1 M92844 regulator (GOS24) zinc-finger helicase (hZFH) 2 U91543 + + + + + Zn-15 related zinc finger 1 U22377 + + + protein (rlf) Zn-15 related zinc finger 1 U22377 protein (rlf) (non-exact 56%) ZNF80-linked ERV9 long 1 X83497 terminal repeat ZW10 (Drosophila) 2 U54996 + homolog, centromere/kinetochore protein (ZW10) zyxin (ZYX) 4 X95735 Column 1: List of unique genes derived from 6,283 known ESTs from blood cells. Column 2: Number of genes found in randomly sequenced ESTs from blood cells. Column 3: Accession number. Column 4: “+” indicates the presence of the unique gene in publicly available cDNA libraries of blood (Bl), brain (Br), heart (H), kidney (K), liver (Li) and lung (Lu). **Comparison to previously identified tissue-specific genes was determined using the GenBank of the National Centre of Biotechnology Information (NCBI) Database.

Discussion

Every cell and tissue comprising the human body share the necessary genetic information required to maintain cellular homeostasis. These “housekeeping” genes function in basic cellular maintenance, including energy metabolism and cellular structure in all cell types. However, in certain situations, even the housekeeping genes show altered expression. Thus, it is necessary to define the use of these genes as internal controls from one investigation to another. Current results from the human blood cell EST database indicate that over 50% of the transcripts are widely expressed throughout the human body. Most of the cell or tissue specific genes are also detectable in blood cells by RT-PCR analysis.

For example, isoformic myosin heavy chain genes are known to be generally expressed in cardiac muscle tissue. In the rodent, the βMyHC gene is only highly expressed in the fetus and in diseased states such as overt cardiac hypertrophy, heart failure and diabetes; the βMyHC gene is highly expressed shortly after birth and continues to be expressed in the adult heart. In the human, however, βMyHC is highly expressed in the ventricles from the fetal stage through adulthood. This highly expressed βMyHC, which harbours several mutations, has been demonstrated to be involved in familial hypertrophic cardiomyopathy (Geisterfer-Lowrance et al. 1990). It was reported that mutations of βMyHC can be detected by PCR using blood lymphocyte DNA (Ferrie et al., 1992). Most recently, it was also demonstrated that mutations of the myosin-binding protein C in familial hypertrophic cardiomyopathy can be detected in the DNA extracted from lymphocytes (Niimura et al., 1998).

Similarly, APP and APC, which are known to be tissue specific and predominantly expressed in the brain and intestinal tract, are also detectable in the transcripts of blood. These cell- or tissue-specific transcripts are not detectable by Northern blot analysis. However, the low number of transcript copies can be detected by RT-PCR analysis. These findings strongly demonstrate that genes preferentially expressed in specific tissues can be detected by a highly sensitive RT-PCR assay. In recent years, evidence has been obtained to indicate that expression of cell or tissue-restricted genes can be detected in the peripheral blood of patients with metastatic transitional cell carcinoma (Yuasa et al. 1998) and patients with prostate cancer (Gala et al. 1998).

Atrial natriuretic factor (ANF) and zinc finger protein (ZFP), which are known to be highly expressed in heart tissue biopsies and in the plasma of heart failure patients, are also detectable in the transcripts of blood. Differential expression of zinc finger protein among the normal, diabetic and asymptomatic preclinical subjects may have additional value as a prophylactic “early warning system”. On a related note, there is now more attention/discussion in the cardiovascular disease field being focused on Syndrome X, loosely defined as a continuum of hypertension, increasing sugar levels, diabetes, kidney failure, culminating in heart failure, with the possibility of stroke and heart attack at any time in the continuum. The early identification of patients at risk of organ failure has been a challenge to the medical community for some time and the present method has the potential of resolving or, at least, ameliorating this challenge.

The present invention demonstrates that a simple drop of blood may be used to determine the quantitative expression of various mRNAs that reflect the health/disease state of the subject through the use of RT-PCR analysis. This entire process takes about three hours or less. The single drop of blood may also be used for multiple RT-PCR analyses. There is no need for large samples and/or costly and time-consuming separation of cell types within the blood for this method as compared to the methods described by Kimoto (1998) and Chelly et al. (1989; 1988). It is believed that the present finding can potentially revolutionize the way that diseases are detected, diagnosed and monitored because it provides a non-invasive, simple, highly sensitive and quick screening for tissue-specific transcripts. The transcripts detected in whole blood have potential as prognostic or diagnostic markers of disease, as they reflect disturbances in homeostasis in the human body. Delineation of the sequences and/or quantitation of the expression levels of these marker genes by RT-PCR will allow for an immediate and accurate diagnostic/prognostic test for disease or to assess the efficacy and monitor a particular therapeutic.

In addition to RT-PCR, other methods of amplifying may also be used for the purpose of measuring/quantitating tissue-specific transcripts in human blood. For example, mass spectrometry may be used to quantify the transcripts (Koster et al., 1996; Fu et al., 1998). The application of presently disclosed method for detecting tissue-specific transcripts in blood does not restrict to subjects undergoing course of therapy or treatment, it may also be used for monitoring a patient for the onset of overt symptoms of a disease. Furthermore, the present method may be used for detecting any gene transcripts in blood. A kit for diagnosing, prognosing or even predicting a disease may be designed using gene-specific primers or probes derived from a whole blood sample for a specific disease and applied directly to a drop of blood. A cDNA library specific for a disease may be generated from whole blood samples and used for diagnosis, prognosis or even predicting a disease.

The following references were cited herein:

-   Claudio J O et al. (1998). Genomics 50:44-52. -   Chelly J et al. (1989). Proc. Nat. Acad. Sci. USA. 86:2617-2621. -   Chelly J et al. (1988). Nature 333:858-860. -   Drews J & Ryser S (1997). Nature Biotech. 15:1318-9. -   Ferrie R M et al. (1992). Am. J. Hum. Genet. 51:251-62. -   Fu D-J et al. (1998). Nat. Biotech 16: 381-4. -   Gala J L et al. (1998). Clin. Chem. 44 (3):472-81. -   Geisterfer-Lowrance A A T et al. (1990). Cell 62:999-1006. -   Groden J et al. (1991). Cell 66:589-600. -   Hwang D M et al. (1997). Circulation 96:4146-4203. -   Jandreski M A & Liew C C (1987). Hum. Genet. 76:47-53. -   Jin O et al. (1990). Circulation 82:8-16 -   Kimoto Y (1998). Mol. Gen. Genet. 258:233-239. -   Koster M et al. (1996). Nat. Biotech 14: 1123-8. -   Liew & Jandreski (1986). Proc. Nat. Acad. Sci. USA. 83:3175-3179 -   Liew C C et al. (1990). Nucleic Acids Res. 18:3647-3651. -   Liew C C (1993). J Mol. Cell. Cardiol. 25:891-894 -   Liew C C et al. (1994). Proc. Natl. Acad. Sci. USA. 91:10645-10649. -   Liew et al. (1997). Mol. and Cell. Biochem. 172:81-87. -   Niimura H et al. (1998). New Eng. J. Med. 338:1248-1257. -   Ogawa M (1993). Blood 81:2844-2853. -   Santoro I M & Groden J (1997). Cancer Res. 57:488-494. -   Yuasa T et al. (1998). Japanese J. Cancer Res. 89:879-882.

Any patents or publications mentioned in this specification are indicative of the levels of those skilled in the art to which the invention pertains. Further, these patents and publications are incorporated by reference herein to the same extent as if each individual publication was specifically and individually indicated to be incorporated by reference.

One skilled in the art will appreciate readily that the present invention is well adapted to carry out the objects and obtain the ends and advantages mentioned, as well as those objects, ends and advantages inherent herein. The present examples, along with the methods, procedures, treatments, molecules, and specific compounds described herein are presently representative of preferred embodiments, are exemplary, and are not intended as limitations on the scope of the invention. Changes therein and other uses will occur to those skilled in the art which are encompassed within the spirit of the invention as defined by the scope of the claims. 

1. A method of profiling gene expression in a human subject, the method comprising: determining a level of RNA encoded by a gene in a blood sample of the subject, wherein the gene is identified as KIAA0796, thereby profiling gene expression in a human subject.
 2. The method of claim 1, wherein the subject has a disease.
 3. The method of claim 2, wherein the disease is colorectal cancer.
 4. The method of claim 1, wherein the subject is healthy.
 5. The method of claim 1, wherein determining the level is performed using at least one oligonucleotide of predetermined sequence.
 6. The method of claim 5, wherein the at least one oligonucleotide is specific for RNA encoded only by the gene in blood of human subjects, and/or is specific for cDNA complementary to RNA encoded only by the gene in blood of human subjects.
 7. The method of claim 6, wherein determining the level is performed by amplifying of RNA encoded by the gene to form amplified product, using at least one primer, and quantifying the amplified product, wherein the at least one oligonucleotide comprises the at least one primer.
 8. The method of claim 6, wherein determining the level is performed by hybridizing cDNA complementary to RNA encoded by the gene with at least one immobilized probe to form hybridization product, and quantifying the hybridization product, wherein the at least one oligonucleotide comprises the at least one probe.
 9. The method of claim 1, wherein determining the level is performed by amplifying RNA encoded by the gene.
 10. The method of claim 1, wherein determining the level is performed using an immobilized probe.
 11. The method of claim 1, wherein determining the level is performed by quantifying cDNA generated from RNA encoded by said gene.
 12. The method of claim 1, wherein determining the level is performed by quantifying EST generated from RNA encoded by the gene.
 13. The method of claim 1, wherein the level of RNA encoded by the gene is determined relative to a level of RNA encoded by an internal control gene in the blood sample.
 14. A method of characterizing a body state in a human subject, the method comprising: determining a level of RNA encoded by a gene in a blood sample of the subject, wherein the gene is identified as KIAA0796, thereby characterizing a body state in a human subject.
 15. The method of claim 14, wherein the body state is a disease.
 16. The method of claim 15, wherein the disease is colorectal cancer.
 17. The method of claim 14, wherein the subject is healthy.
 18. The method of claim 14, wherein determining the level is performed using at least one oligonucleotide of predetermined sequence.
 19. The method of claim 18, wherein the at least one oligonucleotide is specific for RNA encoded only by the gene in blood of human subjects, and/or is specific for cDNA complementary to RNA encoded only by the gene in blood of human subjects.
 20. The method of claim 19, wherein determining the level is performed by amplifying of RNA encoded by the gene to form amplified product, using at least one primer, and quantifying the amplified product, wherein the at least one oligonucleotide comprises the at least one primer.
 21. The method of claim 19, wherein determining the level is performed by hybridizing cDNA complementary to RNA encoded by the gene with at least one immobilized probe to form hybridization product, and quantifying the hybridization product, wherein the at least one oligonucleotide comprises the at least one probe.
 22. The method of claim 14, wherein determining the level is performed by amplifying RNA encoded by the gene.
 23. The method of claim 14, wherein determining the level is performed using an immobilized probe.
 24. The method of claim 14, wherein determining the level is performed by quantifying cDNA generated from RNA encoded by said gene.
 25. The method of claim 14, wherein determining the level is performed by quantifying EST generated from RNA encoded by the gene.
 26. The method of claim 14, wherein the level of RNA encoded by the gene is determined relative to a level of RNA encoded by an internal control gene in the blood sample.
 27. A method of identifying a potential marker of a disease, the method comprising: (a) determining a level of RNA encoded by a gene in blood samples of human subjects having the disease, and a level of RNA encoded by the gene in blood samples of human subjects not having the disease, wherein the gene is KIAA0796; and (b) comparing the levels with each other, wherein a determination, resulting from step (b), of a significant difference between the levels identifies the gene as a potential marker of the disease.
 28. The method of claim 27, wherein determining the level in blood samples of human subjects having the disease, and/or wherein determining the level in blood samples of human subjects not having the disease is effected using at least one oligonucleotide of predetermined sequence.
 29. The method of claim 28, wherein the at least one oligonucleotide is specific for RNA encoded only by the gene in blood of human subjects, and/or is specific for cDNA complementary to RNA encoded only by the gene in blood of human subjects.
 30. The method of claim 28, wherein determining the level in blood samples of human subjects having the disease, and/or wherein determining the level in blood samples of human subjects not having the disease is effected by amplifying RNA encoded by the gene to form amplified product, using at least one primer, and quantifying the amplified product, wherein the at least one oligonucleotide comprises the at least one primer.
 31. The method of claim 28, wherein determining the level in blood samples of human subjects having the disease, and/or wherein determining the level in blood samples of human subjects not having the disease is effected by hybridizing cDNA complementary to RNA encoded by the gene with at least one immobilized probe to form hybridization product, and quantifying the hybridization product, wherein the at least one oligonucleotide comprises the at least one probe.
 32. The method of claim 27, wherein determining the level in blood samples of human subjects having the disease is effected by quantifying cDNA generated from RNA encoded by the gene and/or by quantifying EST generated from RNA encoded by the gene; and/or wherein determining the level in blood samples of human subjects not having the disease is effected by quantifying cDNA generated from RNA encoded by the gene and/or by quantifying EST generated from RNA encoded by the gene.
 33. The method of claim 27, wherein the level in the blood samples of subjects having the disease is relative to a level of RNA encoded by a housekeeping gene in the blood samples of subjects having the disease; and/or wherein the level in the blood samples of subjects not having the disease is relative to a level of RNA encoded by a housekeeping gene in the blood samples of subjects not having the disease.
 34. The method of claim 27, wherein the subjects not having the disease are healthy subjects.
 35. The method of claim 27, wherein the blood samples of human subjects having the disease comprise one or more cell types selected from the group consisting of: granulocytes, monocytes, CD19+ cells and CD3+ cells; and/or wherein the blood samples of human subjects not having the disease comprise one or more cell types selected from the group consisting of: granulocytes, monocytes, CD19+ cells and CD3+ cells.
 36. The method of claim 27, wherein the difference is a decrease in the level in the blood samples of subjects having the disease relative to the level in the blood samples of subjects not having the disease.
 37. A method of identifying a potential marker for differentiating between different body states, the method comprising: (a) determining a level of RNA encoded by a gene in blood samples of human subjects having a first body state, and a level of RNA encoded by the gene in blood samples of human subjects having a second body state, wherein the second body state is different from the first body state, and wherein the gene is KIAA0796; and (b) comparing the levels with each other, wherein a determination, resulting from step (b), of a significant difference between the levels identifies the gene as a potential marker for differentiating between the first body state and the second body state.
 38. The method of claim 37, wherein determining the level in blood samples of human subjects having the first body state, and/or wherein determining the level in blood samples of human subjects having the second body state is effected using at least one oligonucleotide of predetermined sequence.
 39. The method of claim 38, wherein the at least one oligonucleotide is specific for RNA encoded only by the gene in blood of human subjects, and/or is specific for cDNA complementary to RNA encoded only by the gene in blood of human subjects.
 40. The method of claim 38, wherein determining the level in blood samples of human subjects having the first body state, and/or wherein determining the level in blood samples of human subjects having the second body state is effected by amplifying RNA encoded by the gene to form amplified product, using at least one primer, and quantifying the amplified product, wherein the at least one oligonucleotide comprises the at least one primer.
 41. The method of claim 37 wherein the level in the blood samples of subjects having the first body state is relative to a level of RNA encoded by a housekeeping gene in the blood samples of subjects having the first body state; and/or wherein the level in the blood samples of subjects having the second body state is relative to a level of RNA encoded by a housekeeping gene in the blood samples of subjects having the second body state.
 42. The method of claim 38, wherein determining the level in blood samples of human subjects having the first body state, and/or wherein determining the level in blood samples of human subjects having the second body state is effected by hybridizing cDNA complementary to RNA encoded by the gene with at least one immobilized probe to form hybridization product, and quantifying the hybridization product, wherein the at least one oligonucleotide comprises the at least one probe. 